d*********g
发帖数: 2906 | 1 http://www.nytimes.com/2013/05/11/world/asia/zhu-ling-case-re-e
1990s Poisoning Case Re-emerges, Unleashing Fresh Chinese Fury
By ANDREW JACOBS
Published: May 10, 2013
BEIJING — The mysterious illness began with crippling stomach pain,
followed by blurry vision and sudden hair loss. By the time Zhu Ling, a
talented musician and chemistry student at one of China’s top universities,
emerged from a coma weeks later, she was partially paralyzed and nearly
blind, her faculties reduced to those of a c... 阅读全帖 |
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j******l
发帖数: 10445 | 2 钓鱼贴，这个是日本核泄漏后的残物。
http://world.time.com/2013/10/03/fukushimas-fallout-the-half-li
不过日本确实满大街都是卖饮料卖香烟卖啤酒的vendor machine。差不多每200米一个。
Fukushima’s Fallout: The Half-Lives of Nuclear Refugees
To this day, the plant still leaks toxic, radioactive water and tens of
thousands of “nuclear refugees” from nearby towns are still outcasts in
their own land.
Oct. 03, 20138 Comments
prev1 of 17next
Broken Lives of Fukushima
Damir Sagolj / Reuters
A vending machine, brought inland by a tsunami, is seen in a aban... 阅读全帖 |
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k*****e
发帖数: 22013 | 3 唉，说的容易啊。
问题是Toxic的人，到处放毒，不理他，放任他污染一群人，
最后投票的时候来了，怎么办？
所以，只能定期地放出自然科学来，
让大家看看真相，清除一下毒素污染。
只要知道这个东西，不是给toxic的人看的，
不要让他们影响了心情就好。 |
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C*******g
发帖数: 9288 | 4 来自主题: MiddleSchool版 - 辣死人了 倒是某次在某旅游点一家专卖各种希奇古怪辣椒产品的小店请回一
瓶叫做“toxic waste“的辣油，做菜时点了寥寥几滴，结果辣得全家人仰马
翻。
这个太厉害了！
听得江湖传言仲雪镇近日过客寥寥，唯有十四妹孤身一人在镇上升幡设坛，
广交天下豪杰，特来拜望。:-)
话说十多年前俺们公司初创时，俺和当时的创业老板远赴Lake Tahoe做个
项目，晚上光顾当地唯一一家墨西哥餐馆。俺们两人都是嗜辣成性，那天
也是穷极无聊，决定略事“挑衅”，五次三番告诉店小二他那hot sauce不
够辣，另换下一个层次的伺候，结果终于逼出了大厨留给自己享用的
habañero sauce。那是俺第一次邂逅habañero，领教之后觉得也不过
尔尔。倒是某次在某旅游点一家专卖各种希奇古怪辣椒产品的小店请回一
瓶叫做“toxic waste“的辣油，做菜时点了寥寥几滴， |
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s*******y
发帖数: 2977 | 5 "Grapes and Raisins
These foods' toxicity has mainly been found in dogs, in quantities of
varying amounts. The ASPCA advises: "As there are still many unknowns with
the toxic potential of grapes and raisins, the ASPCA Animal Poison Control
Center advises not giving grapes or raisins to pets in any amount." That's
good enough for me. "
http://cats.about.com/cs/catfood/a/humanfood.htm
还好所有糖分都被我吃了嚼了，他只是吃皮。 |
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G**********e
发帖数: 11693 | 6 今天朋友来我们家玩，晚上出去吃饭时，我走在最前面，我问了一句，“把狗都关好了
吗”，我就先出门了。
一个多小时后我们回家，一开门小不点居然已经在门口greet我们，我的第一个反应就
是，完了，茶几上的巧克力一定被她吃得一点也不剩了！我很了解我家小不点儿，她平
时是一只很乖很规矩的小女孩狗，我们在她面前吃东西她从来都会装出一副很有风度的
样子，对吃的表现得很有克制力。但实际上她是一直惦记着食物的，一旦人前脚一走开
，她后脚立刻变成一只最猥琐的小狗，猛虎扑兔一样的飞奔着去偷吃东西（亲眼见过很
多次）。今天的情况应该就是这样，可能因为混乱，所有的人都以为狗已经被安顿好了
，我们就一行人出了门。回来茶几上一看果然如我所料，巧克力全部被吃得光光的。我
连她是以什么顺序吃掉的都知道，一定是先吃了reese peanut butter，然后吃了white
chocolate with hazelnut，最后可能还吃了蓝粉白色的marshmallow。
以前从来没有遇到过这种情况，只知道chocolate对狗来说是highly toxic的，甚至可
以造成死亡。所以马上在网上查找处理方法。网上说吃过之... 阅读全帖 |
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R******d
发帖数: 5739 | 7 没问题就好了？ 我也第一次听说， 所以google一下，
http://www.entirelypets.com/toxicfoods.html
quote
Onions and garlic contain the toxic ingredient thiosulphate. Onions are more
of a danger. Dogs affected by onion toxicity will develop hemolytic anemia,
where the pet's red blood cells burst while circulating in its body.
Symptoms include Hemolytic Anemia, labored breathing, liver damage, vomiting
, diarrhea, and discolored urine.
The poisoning in dogs occurs a few days after the pet has eaten the onion.
All forms of... 阅读全帖 |
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D**N
发帖数: 1440 | 11 感觉凤凰男里NPD相当多，跟这种人一起过，太辛苦。他们基本无一例外的擅长操控他
人情绪，在一般朋友眼里，常觉得人有一点乖僻，但亲密一些的话，就非常不舒服。这
种人的一生，是unrealistic control的一生，注定了快乐少郁闷多，将来一定是toxic
parents, toxic in-laws。不知道你如何被他吸引，不妨查找NPD的更多信息，估计你
家人，特别是父亲，也有不少NPD特征，让你对emotional & verbal abuse习以为常。
祝好。 |
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x****n
发帖数: 2149 | 12 【 以下文字转载自 ChinaNews 讨论区 】
发信人: Toxic (toxic), 信区: ChinaNews
标 题: 一篇中国高考作文从及格变优秀的背后
发信站: BBS 未名空间站 (Mon Jul 2 13:39:56 2007)
记者蒋昕捷／被“打捞”出的优秀作文终审评价提升17分。评分导向：秋雨体时髦，质
朴文风就无出头之日？
这是一篇被“打捞”出来的高考优秀作文。
最先碰到它的阅卷老师给了36分，刚及格（高考作文满分为60分）；二评的老师判给它
42分----这属于大多数考生都能得到的基本分。按照预设程序，一评、二评相差6分，
它被电脑传给第三位老师。第三位老师判39分。
“背靠背”的电脑阅卷降低了“串分”的可能性。这表明3位老师对它的评价相差不远。
复查阶段，江苏省高考语文阅卷组组长何永康教授发现了这篇综合判定为37分的《怀想
天空》。反复读了3遍，何永康终于下决心给它54分。从阅卷程序上看，这属于“终审
”，比原先的评价高了17分。
从1977年恢复高考算起，何永康从事语文阅卷工作已经30年。今年，他的职责是在及格
线附近的作文里“拾遗”，但是像这样的情况 |
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o**v
发帖数: 1662 | 13 re【 在 Toxic (toxic) 的大作中提到: 】 |
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a***a
发帖数: 40617 | 14 尽管很多strain已经声称被敲掉了所有DNA修复的系统,但是这种情况我也碰到过
你有没有注意到你用DH5a的时候菌有没有长得很慢,或者clone很少的情况
有的时候这些东西对他们来说太过于toxic,所以活下来的都是有deletion的
(DNA水平的toxic,或者有表达系统的basal leaking)
没太好办法,如果是蛋白水平的,你可以试着加glucose
如果是DNA水平的,你可以有2个办法
1.换strains
2.还是用某个strain,然后大量做,用原位杂交的方法检测完整性(自己设计杂交引物)
这样可以大批量的筛几万个clone,最后应该可以筛出来
old school stuff, but works
good luck |
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f********x
发帖数: 451 | 15 这两个新闻不知道为什么被删掉了。可能怕引起恐慌。
Search results for: monroe man death by thallium | Straightly News
australian flood facts (1),pictures of scheneker family (1),monroe man death
by thallium (1),monroe man death thallium (2),Xiaoye Wang (1),hosni mubarak
...
Toxic substance eyed in man's death in Monroe Twp. - News12
Jan 28, 2011... toxic metal called Thallium, which is suspected in the man's
death. ... Hazmat team investigates Monroe Township home after man's death
... |
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t*****s
发帖数: 1309 | 16 对
蓝宝迪兰这类AIB很少出过电气性能强于公版的高端卡，即使是蓝宝TOXIC也是在PWM芯
片，MOSFET之类料件上基于公版进行控制成本的产物
散热器工艺就更不用多提，TOXIC能开模做OTES已经是三大厂之外的翘楚了 |
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a***o
发帖数: 129 | 17 Try that alternative protocol in current protocols in molecular biology which
use BES instead of HEPES.I got much higher efficiency than with HEPES, and I
didn't find any obvious toxicity.
Toxicity may also be cell type specific. Regular HEK293 and Hela cell which I
used seem all right with CaP
is |
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e****a
发帖数: 17 | 18 the toxicity depends on which cell line you are using
generally, CaP is less toxic than lipid methods in my hands.
and what construct you are tranfecting in to the cells?
is it lethal to cells? |
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a***o
发帖数: 129 | 19 It's not availbale in the web, but in the book "current protocols in molecular
biology". Most molecular biology labs should have it. I am sure you can find
one in either your lab or a nearby one. They are 3 huge red binders. A concise
version "short protocols in molecular biology" also exist.
Basically the method is the same as HEPES one. If you cannot find it I can
find you a recipe when I go back to lab.
As for toxicity, Roche's fugene 6 is famous for lower toxicity than other
liposomal method |
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s*****o
发帖数: 2490 | 20 chronic toxicity有两种model，一种是一次性摄入大剂量的毒物，而且无法代谢，造
成chronic exposure，这种model不常见，主要见于放射性物质的摄入。第二种model是
长期摄入毒物，而且摄入量大于代谢量，这种model是比较常见的，这种model的
exposure基于两点，第一是长期持续摄入，第二是毒物在体内代谢速度小于摄入速度造
成积累。bt toxin这类蛋白toxin很难满足第二点，这也是为什么很多水溶性的
toxicants/toxins很难造成积累毒性的原因，他们通过排泄系统的速度都很快，很难积
累。
incorporated |
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s******y
发帖数: 28562 | 21 哎，你是真的学生物的么？如果一个研究证明吃那个转基因水稻和吃一般水稻
没有任何差异，难道这个不就是一个正的结果么？为什么不能发？
另外，我再强调一遍你不要把我和那个２００９年的文章捆绑到一起．我已经说
了，我对那个结果持保留态度，尽管那个文章貌似认为转bt protein 有毒，但是我不
希望就那么一片孤立数据就作结论，希望等到有人独立的重复了再作结论．
我记得我说了都不止一遍了．你为什么还是没完没了的拿那个文章往我脸上贴金？那个
文章，一，不是我做的，二，我也没有相信他们的结果．
我唯一说的就是目前＂没有任何可靠的数据＂，这个说法还不够清楚么？ 相反，你这
么支持的转基因，它的长期安全性，却连像样的数据都没有，某个人举出的一个例子居
然是１９７３年的．你觉得在对待这个问题上，是你不够小心还是我不够小心？
们在2007年的那篇）
Sciences in June 2009, Séralini and colleagues have repeated their claims
made in an earlier article (Séraliniet al., 2007) that ... 阅读全帖 |
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s*****o
发帖数: 2490 | 22 赞同你就事论事的态度，虽然我们的观点不同。
关于bt的积累毒性我想说说。蛋白类的toxin一般来说是不符合积累毒性的标准的，因
为他们在体内的代谢非常快，不会造成chronic exposure，也就不会造成chronic
toxicity。据我所知，没有那种蛋白toxin会造成chronic toxicity（如果有，请告知
）。具体到bt toxin，消化模拟有人做过，不过如你所说，这个试验有缺陷，不过即使
bt蛋白不会被降解，也会随着粪便排出体外，不会进入内环境造成chronic exposure；
退一步说即使bt蛋白会被完整的吸收入血液，免疫系统也会清除这些外源蛋白，这个也
是有人做过的（三种途径，口服，呼吸，静脉注射).
所以说对bt蛋白来说，积累毒性的可能性非常非常低。毒理学工作者根据这些毒理学常
识没有做bt的积累毒性试验是可以理解的，就好比在文献上不会看到水的积累毒性一样
，这是个常识问题。
另外，在现在的数据库中还是有bt的积累毒性数据的，不过我没有看到那个参考文献的
原文，所以也没有冒然提出来，链接在这
http://npic.orst.edu/factsheet... 阅读全帖 |
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B*****n
发帖数: 5 | 23 Anyone has inside information on this issue ?
http://www.gmwatch.org/component/content/article/11573-gm-indus
In the US, under the Federal Food, Drug and Cosmetic Act of 1938, the FDA is
responsible for ensuring that food is safe to eat, although by statute, it
regulates only food additives. By that definition, most crops are exempt
from FDA approval, although companies tasked with ensuring their products
are safe often voluntarily submit a considerable amount of information.
Certain types of co... 阅读全帖 |
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h********r
发帖数: 519 | 24 现在最重点的是soluble ab oligomers, rather than ab fibrils or monomers, are the most toxic species. The origin of ab toxicity may come from the membrane-disruption. Ca overload may be consequence of membrane disruption due to the formation of ion channel. |
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n********k
发帖数: 2818 | 25 仅有几
个克隆，送过去测序，要做的8个构建株里面只有一个对的，其他基本上都是在Bgl2那
一段的引物地方要么有突变要么就是缺失。
well, could you start with these wrong ones now and just do some mutagenesis
, like you did with dpn1 ones...it would be much easier if it were due to
digestion/ligation etc...but it won't solve the problem if your fragments
are toxic or have too many repeats etc...It is a bit strange that it only
happen to your primer region in all the constructions though...if it is
toxic or due to recombination, it could happen to any regions or... 阅读全帖 |
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xf
发帖数: 68 | 26 我有一个朋友，今年暑假要毕业。是IVY动物系的，研究家禽的。
有几篇Poultry Science的文章，
大家看看这样的研究经历和会的技术手段找什么样的博士后又机会。工业界如何呢？
他老板快退休了，也不知道能有多大帮忙。
谢谢
RESEARCH EXPERIENCE
• Designed and performed experiments to investigate the embryonic
development of chicken under various cholesterol-depleted conditions.
• Modified and improved the yolk replacement technique.
• Determined the cholesterol requirement for embryos to develop,
hatch, and grow normally.
• Determined the toxic level of beta-cyclodext... 阅读全帖 |
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S*********s
发帖数: 304 | 28 I agree. Old fashion phenotypic screen do bring us many chemodrugs(Ref: The
Story of Taxol).
But when toxicity comes, it is hard to eliminate it without knowing target
or potential targets.
With increasing analysis power of sequencing,metabolomics,and proteomics, in
the future we can evaluate toxicity of lead compounds using multi-Omics
approach and use that information to guide SAR optimization. |
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l*****3
发帖数: 12 | 29 不就是artificial enzyme complex么，09年nbt keasling那片，后来igem的nas，然后
vt zhang的angew都是这个套路么，这不就用个polymer代替下docker分子么？
Nat Nanotechnol. 2013 Feb 17. doi: 10.1038/nnano.2012.264. [Epub ahead of
print]
Biomimetic enzyme nanocomplexes and their use as antidotes and preventive
measures for alcohol intoxication.
Liu Y, Du J, Yan M, Lau MY, Hu J, Han H, Yang OO, Liang S, Wei W, Wang H, Li
J, Zhu X, Shi L, Chen W, Ji C, Lu Y.
Source
1] Key Laboratory of Functional Polymer Materials, Ministry of Education,
and I... 阅读全帖 |
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s******s
发帖数: 55 | 30 http://www.reuters.com/article/2013/05/15/us-cancer-chemo-idUSB
(Reuters) - After decades of using one-size-fits-all therapies to combat
cancer, doctors are using new tools to help decide when their patients can
skip chemotherapy or other harsh treatments.
An approach to oncology that has been in place for decades is beginning to
yield to an arsenal of long-term clinical studies, genetic tests and novel
drugs that target cancer cells and their infrastructure.
"What is happening is a combination ... 阅读全帖 |
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h*******o
发帖数: 4884 | 31 PhaseI 主要是toxicity
Phase IIa 传统来讲 主要是pk／pd以及toxicity， 可以适当寻求efficacy的线索 |
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H*****e
发帖数: 120 | 32 Here are some information that may be interesting to you. But you need to
check the literature yourself since I heard most of them from a friend
working on it.
1. Acetate-T is the synthesized form that chemist believe will be
bioavailable. If you can find some PK/PD data, it will be believable. Succi
-T is the so-called conjugated form in vivo, a product by Phase I and II
enzymes. Many chemicals will be converted to this kind of form in liver to
further process. I am not sure what kind of ex... 阅读全帖 |
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y***u
发帖数: 7039 | 33 Nature要为孟山都背书啊？
孟家的实验只作了三个月， 而肿瘤是在四个月后才出现。。。
New research out of France has linked both an herbicide and a genetically
modified corn to organ damage, tumors and early death among rats, prompting
a call for greater regulation of GM foods among sustainable agriculture
advocates.
The study – published Wednesday in Food and Chemical Toxicology – found
that rats who were exposed to Roundup, a weed killing herbicide, and rats
who were fed Roundup-resistant corn developed mammary tumors, kidney and
liv... 阅读全帖 |
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y***u
发帖数: 7039 | 34 请问方舟子： RoundUp残留在转基因作物上是多少， 煮熟了是不是就没有危害了？
New research out of France has linked both an herbicide and a genetically
modified corn to organ damage, tumors and early death among rats, prompting
a call for greater regulation of GM foods among sustainable agriculture
advocates.
The study – published Wednesday in Food and Chemical Toxicology – found
that rats who were exposed to Roundup, a weed killing herbicide, and rats
who were fed Roundup-resistant corn developed mammary tumors, kidney and
liver ... 阅读全帖 |
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t*d
发帖数: 1290 | 35 Sunnyday had made it clean. If 0.01% insects had responses to the Bt protein
, it won't come out with significant toxicity.
But if 0.01% human population might be hurt by the Bt protein, it means >
100k people will be hurt in China. That is why you need more caution.
It is the correct way to go to sit on "Caution" whenever you are talking
about potential toxicity on human being.
leakage |
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s*****o
发帖数: 2490 | 36 另外几个毒理学上的常识想和您探讨，第一任何物质在毒理学上讲都是toxic的，只要
是有途径被人摄入都是有risk的，比如维生素还真的不一定比bt toxin毒性低，所以对
任何一种GM crop都应该有严谨的risk assessment过程，不仅仅只是对转bt的作物。第
二剂量是重要的指标，毒性再高的东西只要剂量低到一定标准以下也是不会对人体有
adverse effect的，所以对农药的risk assessment来说exposure和toxicity是同等重
要的，比如在bt corn或者rice中摄入的被测toxin的量其实和oxicity data比同等重要。 |
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g******4
发帖数: 6339 | 37 【 以下文字转载自 Parenting 讨论区 】
发信人: gogo2004 (挑灯看剑), 信区: Parenting
标 题: 小孩家长必看::[视频] 上百万只蜜蜂离奇死亡，咋回事？ (转载)
发信站: BBS 未名空间站 (Mon Jan 13 22:47:33 2014, 美东)
--------------
看来，首先不能让小孩吃蜂蜜
==========================
Pesticides
Further information: Pesticide toxicity to bees, Imidacloprid effects on bee
population, and Bees and toxic chemicals
According to the U.S. Department of Agriculture, pesticides may be
contributing to CCD.[49] Scientists have long been concerned that pesticides
and possibly some fungi... 阅读全帖 |
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j****n
发帖数: 3370 | 38 我们试过不少方法，有些效果比较明显
1 NEB turbo比top 10好 然后比dh5a好
2 可以试试用30甚至更低的温度，包括recover，inoculation, and liquid culture
Good luck
我最感兴趣的还是这个原因。老板说是所谓的toxic dna，就是plasmid dna形成某种特
殊的结构，然后形成 e coli toxicity 不过没看过这方便的文章。苦于没时间做更深
入的研究。。。
欢迎高手指点。。。
★ 发自iPhone App: ChineseWeb 8.7 |
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s*****o
发帖数: 2490 | 39 唉，我不知道是我表达得不清楚，还是你没有弄清楚我的意思，最后变成了你认为我罗
列protocol的细节了。我从头再整理整理我的思路吧：最开始你认为毒性试验没有用种
子而是用了纯蛋白，你觉得bt protein在种子中可能会导致在胃内不能被充分破坏而进
入肠道对肠道上皮产生毒性。而我认为在acute toxicity中用到的剂量已经非常高了，
相对于在种子中的bt protein的量要高得多得多得多，相对种子里的bt protein也更有
可能躲过胃酸的破坏进入肠道。之后你认为我说的高剂量（我认为那是个会被撑死的剂
量）是个笑话。而我认为你之所以这么认为是你并不了解oral toxicity实验的操作，
而我列出实验细节也是想告诉你你嘲笑我是没有道理的。
另外，你认为bt protoxin在肠道被切割成active protein的可能性不低？据我所知，
现在的这些bt toxin的protoxin，尤其是针对主要农业害虫鳞翅目幼虫的这些bt
protoxin在pH高于9的环境下才会被溶解和酶切，在人的小肠pH不到8的环境里可能性会
高？
当然你说得对，这些没有数据支持，都是基于理论上的... 阅读全帖 |
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o*******a
发帖数: 242 | 40 all bullshit/
the medication this group uses is ketamine, which is a known med used in
the clinical medicine for sedation, analgesia and quick induction of
analgesia. This med is toxic and causes dependence.
Ketamine is not approved by FDA for treatment of depression.
We do not need a toxic and dangerous drug like morphine or ketamine for
anti-depression.
Mechanism is mechanism. Don't say everything is related to medicine/patient
management. Really too far ! |
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n*****t
发帖数: 32 | 41 Here is the website for RTECS® Search.
http://ccinfoweb.ccohs.ca/rtecs/search.html
I need get the toxicity information of P-xylene and the mixture of its
isomers from RTECS. I am doing this upon my friend’s request.
Maybe you have heard about the PX production project by FUJIA (大连福佳化工
厂) in
Dalian, which was vetoed by CAS academicians, Zhao Yufen et al. at Xiamen in
2007.
According to my searches from several websites given below, it seems the
chemical itself is low toxic. No evidence shows |
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w*s
发帖数: 50 | 43 n-Hexane is indeed toxic, it is oxidized metabolites hexane-2,5-dione that
causes CNS break down. Pentane is less toxic, but too volatile. So use
heptane whenever you can. |
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c*t
发帖数: 32 | 45 【 以下文字转载自 Environmental 讨论区 】
发信人: cyt (老五), 信区: Environmental
标 题: Repost - Job opening in Iowa
发信站: BBS 未名空间站 (Fri Feb 8 16:09:45 2013, 美东)
我中午发的工作信息怎么被删了？
Whoever deleted it, and wants to delete it again, please let me know which
role I violated? I just want to help my previous employer to spread the
word and help some recent graduates in Analytical Chemistry and /or
Environmental Chemistry finding their first 'real' job.
Thanks!
______________________________________
State Hygienic Labora... 阅读全帖 |
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发帖数: 1 | 46 ==
The risk of cancer is increasing significantly nowadays, which is a serious
social and health problem threatening human being. Hence, numerous
scientists continuously endeavor on this imperative issue for conquering the
malignant disease and declining the cancer incidence. Due to over 60% of
currently used anticancer agents are derived from natural sources directly
or indirectly, the discovery and development of new effective and safe
cancer inhibitors from folk medicines still is important r... 阅读全帖 |
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