g*******t
发帖数: 51 | 1 独立节TLR1 $80. 金属枪上金属手电。tlr3是塑料的。
tlr3, 非锂电的，要换电池。不过我觉得还好，挺耐用的。价格大概100。昨天订了那
个1000发子弹，hogue grip，还有safari的holster（可以带灯放进去的）
★ Sent from iPhone App: iReader Mitbbs Lite 7.56 |
|
L****S
发帖数: 89 | 2 Thanks for the discussion. I know which papers you are talking about. We
have to think about immunology here.
In the endosomal compartment, for dsRNA, ssRNA, DNA, TLR3/7/9 sense them
accordingly. No big question here.
In the cytosol, dsRNA is a strong "danger" signal showing viral infection
. That's why every cell has PKR, RIG-I/MDA-5, etc. So I speculate, when
liposome delivers ssRNA, RIG-I/MDA-5-mediated cytosolic response dominates
the TLR3 signal, quantitatively or qualitatively.
In the pape... 阅读全帖 |
|
h*******r
发帖数: 847 | 3 http://www.ncbi.nlm.nih.gov/m/pubmed/23284890/
CDA-2, a urinary preparation, inhibits lung cancer development through the
suppression of NF-kappaB activation in myeloid cell.
Wang X, et al. PLoS One. 2012.
Show full citation
Abstract
CDA-2 (cell differentiation agent 2), a urinary preparation, has potent anti
- proliferative and pro-apoptotic properties in cancer cells. However, the
mechanisms of tumor inhibitory action of CDA-2 are far from clear, and
especially there was no report on lung canc... 阅读全帖 |
|
d*******s
发帖数: 15155 | 4 枪托买的是ATI的折叠伸缩枪托（M4式样），记得之前版上谁有推荐过，比较喜欢有腮
托的设计。
Mag Pro的20发弹匣，卖家说30发以上的容易卡壳。
其他还有脚架，带导轨的receiver cover，一个6x的小镜子（短镜不会被蛋壳打到，不
用deflector）。还买了500发的子弹。
手电是之前买的Streamlight TLR3.
肉眼来看其实scope挺亮的，只是屋里太黑，手机照出来效果显得暗。
坑爹的还是那个receiver cover和导气管。
基本所有after market的receiver cover前面做的都比一般的长，所以买回来都要自己
file，还不能多了，不然就松了。最后面的卡槽也要file窄一点点。
air tube的护木本来有个黑色合成材料的，可是要拿掉木头需要敲掉一个rivet，试了
半天无果，最后放弃，其实留个木头也不算很难看吧。
另外新stock换了以后，似乎整体枪管位置比木托时候更低，所以air tube上去以后无
法锁死，只好继续file，就是tube后面链接铁瞄的部分，直到能锁止。
都弄好了之后，发现新弹夹上不去，原来是前面太长了，前面的卡... 阅读全帖 |
|
d*******s
发帖数: 15155 | 5 tlr3, 非锂电的，要换电池。不过我觉得还好，挺耐用的。价格大概100。
昨天订了那个1000发子弹，hogue grip，还有safari的holster（可以带灯放进去的） |
|
|
d*******s
发帖数: 15155 | 7 tlr3我今天打的时候有个问题。
你说的没错，螺丝上紧的，用quarter就可以。因为塑料的，不敢使劲拧。
我打没事，可我室友打了会儿，我就发现手电从轨道最后面滑到最前面，快掉了。估计
是因为他压不住我得枪，甩出来了 |
|
d*******s
发帖数: 15155 | 8 1.你的手好小，lol
2.你是要灯呢，还是也要laser？只是灯的话，stream就够了吧，surefire似乎没有必
要。viridian的也不错，我的green laser+灯就是他家的，laser很亮，灯也比我的
TLR3要亮点。
3.恭喜
Streamlight |
|
d*******s
发帖数: 15155 | 9 不至于吧，看这个数据还是不错的啊。我在Sams也买过那种3 pack的，家用应付停电还
可以，装枪上亮度太差了。
Output: 120 Lumen (AA) or 130 Lumen (CR123)
LED: CREE XR-E Q4-BIN
LED Life: 50,000 hours
Battery Life: 1 hr (AA) or 2 hr (CR123)
Modes: 3 (High, Low, Strobe)
Length: 4.2" (AA) or 3.6" (CR123)
亮度有点低，跟我的TLR3差不多。另外这个电池寿命有点短了，不过compact都不太好
。如果你真的需要一个手电（不是放枪上），那买个随身不算贵。
我觉得手电除了亮度，还有一个就是照的pattern有关，枪上最好找那种散光不严重的
，主要集中在中间，周围有个光晕就好了。
我上次在Lowes买了一个标称160还是180lumen的就感觉挺亮的了。就是个头不算太小。 |
|
|
b*****e
发帖数: 5133 | 11 买了HK不装Surefire拿不出手啊，呵呵。 |
|
i**e
发帖数: 6810 | 12 HK USP以外的几个是1913 rail，可以把TLR放在别的枪上，再入个
Surefire观赏专用，呵呵 |
|
|
c**g
发帖数: 14 | 14 Unlike TLR3 and TLR7/8/9 which are located and act
exclusively from endosome, TLR4 can signal from both cell surface and
locations within the cell. The difference is that, the activation of TLR4 at
cell surface involves Myd88 and leads to NF-kB pathway activation, while
the activation of TLR4 in endosome involves TRIF and leads to IFN production.
面？ |
|
S****r
发帖数: 982 | 15 Then, how could it be explained that dsRNA analogy in culture medium
activates TLR3, while transfected dsRNA analogy activates RIG-1/MDA5?
Thanks in advance!
at
production. |
|
c**g
发帖数: 14 | 16 I think your explanation of location is logical, however I have read a paper
which said that the DOTAP transfection reagents (liposome based) can
directly deliver DNA/RNA into the endosome, and the TLR3 located mainly in
the endosome,so why is RIG-1/MDA5 activated when dsRNA is transfected
through liposome? |
|
h*****t
发帖数: 103 | 17 你把科大看的太简单了。
这里看看科大百人计划中的代表，80后。
http://biox.ustc.edu.cn/szdw/szkxybrjh/201103/t20110305_90718.h
周荣斌 教授，博导，中科院“百人计划”候选人。
代表性学术论文：
1.Zhou R, Yazdi A, Menu P,Tschopp J. A role for mitochondria in NLRP3
inflammasome activation. Nature. 2011 Jan 13;469(7329):221-5
2.Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting
protein links oxidative stress to inflammasome activation. Nat Immunol. 2010
Feb;11(2):136-40.
3.Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor fo... 阅读全帖 |
|
z*t
发帖数: 863 | 18 Beutler得奖，Medzhitov会不会有意见？
http://www.sciencedirect.com/science/article/pii/S1074761309002
Ruslan Medzhitov
This year marks the 20th anniversary of a publication (Janeway, 1989) that
in many ways revolutionized our understanding of the immune system. As part
of the proceedings of the Cold Spring Harbor Symposium on Immune Recognition
, the paper authored by the late Charles A. Janeway, Jr. was not a standard
peer-reviewed publication. In fact, Charlie used to refer to it as “the
best paper I've ... 阅读全帖 |
|
|
p**t
发帖数: 160 | 20 I got it. It seems RIG-I and MDA-5 recognize dsRNA intracellularly.
Does TLR3 do it in a similar way or it recognizes dsRNA which exists
out of cells? |
|
p**t
发帖数: 160 | 21 Got the answer, TLR3, 7, 8, 9 are intracellular TLRs. :p
Thanks! |
|
b****r
发帖数: 17995 | 22 不懂了，TLR3 TLR9 这样的，不能算DNA sensor吗，还是你觉得不是真的？ |
|
