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s******9
发帖数: 283 | 2 Can't expect much to let a very active bacterial nuclease lacking a
stringent proofreading activity play on a genome of 3 billion base pairs. |
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t*******y
发帖数: 21396 | 3 Merck Plans Further Job Cuts
By TESS STYNES And PETER LOFTUS
Merck & Co. said it plans to slash its 81,000-strong workforce by 20% over
the next two years as part of a broad restructuring of its research-and-
development practices, a move aimed at adapting the century-old
pharmaceutical company to shifting market dynamics.
The layoffs, some of which were previously disclosed, in combination with
the closing of a New Jersey facility and the discontinuation of some late-
stage pipeline drugs, are ... 阅读全帖 |
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z****u
发帖数: 1007 | 4 tet on system是有leakage的。 相比下tet off要好得多。
不过现在有些公司有新一代的tet on system.去clonetech看看他们的系统。据公司报
告说比常规tet on system要更stringent.
而且leakage 的问题我个人感觉可以很复杂，依表达组织不同或不同发育期都会有不
同。 |
|
s********3
发帖数: 231 | 5 《科学》对STAP手稿的专家评审意见曝光
《科学》对传说中的STAP细胞论文的三名评审专家意见，过去一直被雪藏，今天终于
被曝光。专家对这一研究的评价不高，认为非常全面的描述性研究，如果结果确定，可
能导致发育生物学大厦的颠覆，其实是不相信这种研究结论。因为没有当时的投稿件，
所以没有办法对这些评价进行更深入分析。不过这些资料显然都在某个地方，只是拥有
的人不愿意拿出来。
Retraction Watch readers are of course familiarwith the STAP stem cell saga,
which was punctuated by tragedy last month whenone of the authors of the
two now-retracted papers in Nature committed suicide.
In June, Science‘s news section reported:
Sources in the scientific community confirm that early version... 阅读全帖 |
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x*****d
发帖数: 704 | 6
hallmark gene sets are very small (50 gene sets) so it is very stringent.
Try C2 CP: Canonical pathways or C5 GO Biological Process. |
|
o****y
发帖数: 138 | 7 JOURNAL OF MATERIALS SCIENCE LETTERS 21, 2002, 285– 287
Characterization of copolymer poly(acrylonitrile) based
polymer electrolytes
H. P. CHEN, J. W. FERGUS
Materials Research & Education Center, 201 Ross Hall, Auburn University,
Auburn, AL 36849, USA
E-mail: j******[email protected]
C. SHANNON
Department of Chemistry, Auburn University, Auburn, AL 36849, USA
Portable electronic equipment places increasingly stringent
requirements on the size, weight, and thus energy
density, of batteries. Lithi |
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m*******l
发帖数: 12782 | 8 【 以下文字转载自 Software 讨论区 】
发信人: liangmaomao (Amy Bishop 拿不到tenure就杀人的生物AP), 信区: Software
标 题: 去年12月《福布斯》文章，波音787软件需重写
发信站: BBS 未名空间站 (Thu Jan 17 17:25:40 2013, 美东)
去年12月《福布斯》文章，波音787软件需重写
http://www.forbes.com/sites/petercohan/2012/12/06/can-boeing-co
My source told me that the ES is a so-called level A system (highest level
of certification) — which must pass stringent testing. Such certification
includes evidence of following processes in development and passing
thousands of tests. Almost every... 阅读全帖 |
|
G****n
发帖数: 145 | 9 But Andrei Shleifer, who won the clark medal is the real deal!
The law and economics of self-dealing[PDF] from uva.nl…, R La Porta, F
Lopez-de-Silanes, A Shleifer - 2005 - nber.org
... Andrei Shleifer Department of Economics Harvard University Littauer
Center M-9 Cambridge,
MA 02138 and NBER a*******[email protected] Page 3. 1 1. Introduction. Over the
last twenty
years, both academic and practical approaches to corporate ...
Cited by 462 - Related articles - Library Search - BL Direct - All 71
vers... 阅读全帖 |
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h********c
发帖数: 223 | 10 Recently I've been looking for school programs and talking to a counselor at
the Career Center in my school. She mentioned that NY and CA states have
more stringent requirements on preparing a teacher. She said hence it is
better to attend programs in those two states because it is "easier" for
people to go from these two states to other states, and it is "harder" for
teachers certified from other states to go to NY and CA. She also mentioned
that there are states on the "second tier", and some |
|
I***a
发帖数: 704 | 11 有人说用GRLOGIC这个层把数字部分框起来会让floating gate check 忽略数字部分
我看了手册，里面说GRLOGIC这个层是
Shape identifies structures that are exempt from
recommended or more stringent layout rule checking.
Intended for IBM use in Digital Library offerings.
什么是Digital Library offerings?
IBM foundry 设计这个层仅仅是为了设置忽略floating gate check的部分，
还是数字部分本来就是可以忽略的？ |
|
l***g
发帖数: 1035 | 12 that swedish guy? his license term is too stringent.. |
|
GC
发帖数: 1409 | 13 Have you ever checked the requirements for taking EIT/PE in IL? It is one of
the most stringent states. Check it out yourself. |
|
m********e
发帖数: 177 | 14 Sounds like a good opportunity to initiate some site remediation projects.
CEPA drafted a couple of new standards for soil and groundwater recently,
but I doubt if 万科 can find someone to cleanup to the standard cost-
effectively. For residential development, they should follow more stringent
standards.
140000m^3 soil + unknown groundwater plume, that will cost a fortune and
take a long time.
Also I don't buy that DDT & 六六六 are the only contaminants. That site used
to make pesticides and paints. |
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a***h
发帖数: 1222 | 15 EPA has poured billions of dollars on site remediation of Superfund sites
with only a handful of them cleaned up.
Basically there is no effective way to clean up soils contaminated by heavy
metal and other nondegradable contaminates.
stringent
used |
|
a*****e
发帖数: 2503 | 16 no problem.
My friends and I did FE in TX and PE in FL.
My suggestion is that you could take PE in a relative stringent state. Or
else in the future, once you transfered to the other state, that state might
not accept your PE or request you take a lot of classes(after they evaluate
your education background) before they accept your PE.
I know 3 senior engineers from Georgia and CA. One PE in Georgia could not
transfer his PE to FL, the other two from CA need to take 5-6 classes before
FL accept |
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g*********i
发帖数: 281 | 17 Re-emphasis of Board Policies
As I said before, as the BM, I wish to be very much hands-off - a more
interventionist approach takes up more time, after all, and we don't have
all that much to spare.I wish to state categorically that I do not have any
desire to suppress criticism; bear in mind, though, that the basic rule of
the board is "please keep discussions generally polite".
That said I will be policing the following categories a bit more stringently
than I may have done in the past:
*Poten |
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r********4
发帖数: 97 | 18 Special Issue for International Journal of Polymer Science
各位学高分子的朋友， 看看有没有相关研究方向的文章考虑submit...
http://www.hindawi.com/journals/ijps/si/672671/cfp/
Functional Polymer Materials from Natural and Sustainable Resources
Call for Papers
Functional polymers represent a class of materials with advanced chemical,
physical, and biological properties, which have found broad uses in both
industry and people’s daily life, including semiconducting materials,
stimuli-responsive materials, and biomimetic mater... 阅读全帖 |
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s***x
发帖数: 1 | 19 Life's Simple 7 has really stringent criteria for BP and FG. FG<100? It's
lucky if I can get most of my patient's
FG to be <200. It's not really surprising that few people can reach this.
The diet order is also very hard to
execute. I'm not surprised the relatively poor Northern Manhattan hispanic
population aren't able to do it. |
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i******b
发帖数: 1780 | 20 I think it is a bad news. Once a lot of people get into this time, the
immigration rule will be stringent next time. |
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s**********8
发帖数: 25265 | 21 你们这两个id 像在自说自话啊 哈哈
i dont think there is stringent rule regarding validation batches, as long
as you clearly stated in ur validation mater plan.
since it is still treated as process validation, it is not commercial
product even though very close, so can not be sold i guess. |
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a*********7
发帖数: 180 | 22 I agree. pharmaceuticals should have complied the most stringent limits
among all others (i.e food, cosmetics, natural health product, etc). i.e ICH
limits,,and EMEA and FDA have guidances for genotoxic impurities... |
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t**n
发帖数: 4365 | 23 FDA网站上就有解释
http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm047470.htm
"FDA approved": Maybe you saw the words on a company's Web site or in a
commercial promoting a new product or treatment. Some marketers may say
their products are "FDA approved," but how can you know for sure?
FDA is responsible for protecting the public health by regulating human and
animal drugs, biologics (e.g. vaccines and cellular and gene therapies),
medical devices, food and animal feed, cosmetics, and products that ... 阅读全帖 |
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o*******t
发帖数: 167 | 24 Yep. "Notoriously" stringent on Drug abuse, HIPPA Regulation, law provision,
etc. I'm floating at Lockhart this weekend. So many hillbillies in Hill
Country. Aww/ |
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p*****w
发帖数: 82 | 25 1) OPT
Although new OPT rules allow 17 months' extension for some students, a much
stringent employment requirement will put more OPT applicants or OPT status
holders in a very harsh situation. In order to be qualified for extension,
one must have a related job first. Moreover, if a OPT student is unemployed
for more than 90 days, he/she could be out of status. This is very tough
for most of international students, especially under current job market.
2) H1B
USCIS just announced that all H1B c |
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g*****u
发帖数: 14294 | 26 There are different tiers of players, big, medium, and small, in HFT. For
ultra high frequency market making, one would certainly need to push their
tech to the extreme. Notwithstanding, there are small prop shops with less
stringent latency requirements, employing different strategies, of course. |
|
g***s
发帖数: 3811 | 27 有兴趣的PM我，这个是比较senior的职位，刚毕业的应该希望不大。
Position Description:
Looking for a senior developer to join the Equity Derivatives Scenarios team
. The Scenarios team is responsible for calculating overnight risk for the
front office, including: traders, risk managers and Strats. These
calculations are performed for all regions running 24/5. The calculation
include various Scenarios, PnL Attribution/PnL Explain, and bucketed Greeks
that are too compute intensive for real-time risk, as well as Mark Review
an... 阅读全帖 |
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S******y
发帖数: 39 | 28 The evolution theory has never been "proven", and no biological or physical
theory has EVER been proven, for that matter. The current theories are the ones
that best explain the observations. Don't argue with me on the definition of
"prove", though, because it is a term with an extremely stringent definition in
science philosophy.
THe evolution theory is widely accepted because it constructs a beautiful theoretical
framework to explain the origin and development of life. Admittedly, exactly beca |
|
g********r
发帖数: 8017 | 29 not every experiment generates expected results you know. What if there's no
real biological difference?
Using a stringent p-value cutoff + a fold change cutoff might work, because
p-value or q-value don't cover absolute amount of change.....and in real
biology each condition may not be a single population blah blah blah ....
use
in
dependent |
|
a****m
发帖数: 693 | 30
model
主要是对他们原理的不同不是很理解：看了半天，大概有个认识了,把别人的slide上的
东西copy下
来，很是拗口。
总的理解是GEE 用的quasi-likelihood numerically solves their parameter, beta
and variance.
mixed model assume normal distribution, and analytically solve the
parameters using ML.
GEE vs MRM
• GEE not concerned with V (yi)
• GEE yields both robust and model-based std errors for beta ;
MRM, in common use, only provides model-based
• GEE solution for all kinds of outcomes; MRM needs to be
derived for each
• For non-no... 阅读全帖 |
|
s**********8
发帖数: 25265 | 31 Center for Devices and Radiological Health
From Wikipedia, the free encyclopedia
Jump to: navigation, search
The Center for Devices and Radiological Health (CDRH) is the branch of the
United States Food and Drug Administration (FDA) responsible for the
premarket approval of all medical devices, as well as overseeing the
manufacturing, performance and safety of these devices. The CDRH also
oversees the radiation safety performance of non-medical devices which emit
certain types of electromagnetic... 阅读全帖 |
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s**********8
发帖数: 25265 | 32 来自主题: MedicalDevice版 - FDA The Food and Drug Administration (FDA or USFDA) is an agency of the United
States Department of Health and Human Services, one of the United States
federal executive departments. The FDA is responsible for protecting and
promoting public health through the regulation and supervision of food
safety, tobacco products, dietary supplements, prescription and over-the-
counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals,
blood transfusions, medical devices, electromagnetic radiati... 阅读全帖 |
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s**********8
发帖数: 25265 | 33 DEFINITIONS:
I. HUMANITARIAN USE DEVICE (HUD): A device that is intended to benefit
patients
by treating or diagnosing a disease or condition that affects fewer than 4,
000
individuals in the United States per year.
II. HUMANITARIAN USE DEVICE EXEMPTION (HDE): Food and Drug Administration
(FDA) approval of an HDE permits the marketing of an HUD, subject to
restrictions
on charges and use. Specifically, HUDs cannot be sold for profit, except in
the
limited circumstance when indicated for use in c... 阅读全帖 |
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s**********8
发帖数: 25265 | 34 A medical device is a product which is used for medical purposes in patients
, in diagnosis, therapy or surgery[citation needed]. Whereas medicinal
products (also called pharmaceuticals) achieve their principal action by
pharmacological, metabolic or immunological means. Medical devices act by
other means like physical, mechanical, physico-chemical or chemical means.
Medical devices are included in the category: Medical technology.
Medical devices include a wide range of products varying in comp... 阅读全帖 |
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h********e
发帖数: 2823 | 35 Source:
http://www.washingtontimes.com/news/2011/apr/13/gao-renews-crit
By MATTHEW PERRONE
WASHINGTON (AP) - Government investigators say the Food and Drug
Administration is putting patients at risk by approving sensitive medical
devices such as hip joints and heart defibrillators under the same
streamlined system intended for power wheelchairs, stitches and catheters.
The Government Accountability Office told Congress Wednesday that the
approvals remain a serious issue for the government _ more... 阅读全帖 |
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s**********8
发帖数: 25265 | 36 http://www.qrasupport.com/FDA_MED_DEVICE.html
Overview: FDA Regulation of Medical Devices
The following information is provided as general guidance to the Food and
Drug Administration (FDA) regulation of medical devices. The Center for
Devices and Radiological Health (CDRH) is the division of FDA responsible
for medical device regulation. CDRH maintains a very informative web site.
The CDRH web site is located at: http://www.fda.gov/cdrh/devadvice/default.htm.
For support in working with the FDA... 阅读全帖 |
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p****y
发帖数: 23737 | 37 Biodiversity Talks Underway in Japan 10/27/2010 10:24:56 PM
http://www.vision.org/visionmedia/article.aspx?id=36375
Global talks on how to preserve the world's natural resources are entering
their final stages in the Japanese city of Nagoya.
High level discussions between environment ministers began on Wednesday
morning, with Japanese Prime Minister Naoto Kan outlining at the opening
ceremony the risks of inaction.
(SOUNDBITE) (Japanese) JAPANESE PRIME MINISTER NAOTO KAN SAYING:
"Today, we are l... 阅读全帖 |
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T******g
发帖数: 21328 | 38 https://www.extremetech.com/extreme/214605-vw-caught-cheating-on-diesel-
emmissions-standards-ordered-to-recall-500000-cars
One possible partial explanation is that VW introduced these changes to cut
down on maintenance costs. As we previously noted, a number of the clean
diesel vehicles use an additive which must be periodically replaced in order
to keep the vehicle’s emissions within range. Critically, the rate of
additive consumption appears to be roughly equal between European and
American v... 阅读全帖 |
|
w*******y
发帖数: 60932 | 39 Save over $165 off cost of new chainsaw compared to amazon.com that is
selling them for $329.99.
You can order a refurbished one for $162 ($179.99 -10% "VMSAVE10" coupon )
directly from VMInnovations at: Husqvarna 445:
http://www.vminnovations.com/product_5009/HUSQVARNA_445_18_Inch
Specs from the website:
Air Purge - Removes air from carburetor and fuel system for easy starting.
Air Injection - Centrifugal air cleaning system removes larger dust and
debris particles before reaching the air filt... 阅读全帖 |
|
w*******y
发帖数: 60932 | 40 Geomag Kids Panels - 36 pieces
Product Features
* Magnetic construction system
* Thousands of geometric forms possible
* Swiss-made quality
* Includes 12 magnetic rods, 10 chromed steel spheres, 6 square panels
and 8 triangular panels (panel colors include: blue, turquoise and white)
* All components manufactured to stringent European and American safety
standards
|
|
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w*******y
发帖数: 60932 | 42 Home Depot is offering the Hampton Bay Amazon Teak Patio Chair Pair for $129
+tax shipped.
This classic arm chair offers a simple design with complete comfort. The
back has an arched top, countered seat and lightly curved arms making this
chair a very popular choice.
Made from beautiful Amazon teak, responsibly harvested according to the
forest stewardship council (FSC) standards which require strict forest
management, as well as stringent environmental, social and economic
responsibility.
Amazo... 阅读全帖 |
|
S*****H
发帖数: 9 | 43 来自主题: _Stockcafeteria版 - AD的原则 * Averaging down should be done on a selective basis for specific
stocks, rather than as a catch-all strategy for every stock in a portfolio.
This strategy is best restricted to high-quality, blue-chip stocks where the
risk of corporate bankruptcy is low. Blue chips that satisfy stringent
criteria - which include a long-term track record, strong competitive
position, very low or no debt, stable business, solid cash flows, and sound
management - may be suitable candidates for averaging down. |
|
N***i
发帖数: 2063 | 44 http://www.zacks.com/commentary/15693/Health+Care+Review+%26+Ou
By: Zacks Equity Research
September 16, 2010 | Comments: 0
Recommended this article (0)
UNH | HUM | HS | UAM | CI | WLP | AET
Print Share
The health care industry is currently undergoing a period of tremendous
uncertainty due to the implications of the recent Health Care Reform Act --
named the PPACA -- after it becomes fully effective.
Why was the reform enacted?
* Health care costs, which have risen rapidly in real terms in... 阅读全帖 |
|
b*****h
发帖数: 3386 | 45 【 以下文字转载自 bluechips 俱乐部 】
发信人: liliwater (lyrist), 信区: bluechips
标 题: Current Strategies
发信站: BBS 未名空间站 (Fri May 7 11:34:38 2010, 美东)
From
http://vixandmore.blogspot.com/2010/05/some-thoughts-on-seis-de-mayo-mini.html
I think it makes much sense:
* The possibility of a fat finger order entry error cannot be dismissed, but
even if there were one or more
unintentional large trades, this does not nullify the concerns about
sovereign debt contagion, breaking of
technical support, recent excessive ... 阅读全帖 |
|
w*******d
发帖数: 3714 | 46 UPDATE 1-Vivus shares fall on regulatory concerns
Tue Jun 15, 2010 3:10pm EDTStocks
* Jefferies: FDA likely to focus on cardiovascular risk
* Lazard downgrades shares to "hold" from "buy"
* Qnexa FDA panel follows Avandia panel
* Shares down 8 pct in afternoon (Adds analyst comment, company comment,
updates stock price)
By Deena Beasley
LOS ANGELES, June 15 (Reuters) - Shares of Vivus Inc (VVUS.O) fell as much
as 9 percent on Tuesday after analysts raised questions about how U.S.
regulators wil... 阅读全帖 |
|
N***i
发帖数: 2063 | 47 【 以下文字转载自 Stockcafeteria 俱乐部 】
发信人: Nanji (Ninja), 信区: Stockcafeteria
标 题: Oil & Gas Industry Stock Review - July 2010
发信站: BBS 未名空间站 (Fri Jul 23 06:26:06 2010, 美东)
By: Zacks Equity Research
July 22, 2010 | Comments: 0
Recommended this article (2)
PBR | PTR | ACGY | CLB | FTI | PTEN | HP | RIG | DO | ESV | RDC | PDE | NE
OUTLOOK
Crude Oil
The improving economic scene, both here in the U.S. as well as worldwide,
had been the main driver of the oil rally that saw the commodity zoom past
the $85 p... 阅读全帖 |
|
f**********g
发帖数: 2252 | 48 Zacks initiating coverage of Clean Diesel Technologies Inc. [CDTI]
Clean Diesel Technologies [CDTI] is a leading provider of pollution control
solutions for gasoline and diesel engines. The company offers both OEM and
after-market products on a worldwide basis. The company was formed by a
merger in October 2010 between CDTI Merger Sub and CSI.
The company recently completed a 3 million share offering for $10 million.
Over the next three years significant on highway diesel vehicle pollution
regul... 阅读全帖 |
|
y*****l
发帖数: 5997 | 49 11:55 Do you think there is > 50% chance someone buys HGSI in next 12 mos.?
Yes
( 68% )No
( 32% )
Thursday October 20, 2011 11:55
11:56 adam feuerstein: Hello! Welcome to the October edition of Biotech
Stock Live Chat.
Thursday October 20, 2011 11:56 adam feuerstein
12:02 adam feuerstein: hi everyone
Thursday October 20, 2011 12:02 adam feuerstein
12:02 adam feuerstein: I'll get started in a minute or so, let folks log in
.
Thursday October 20, 2011 12:02 adam feuerstein
12:02 adam feuers... 阅读全帖 |
|
g********n
发帖数: 2314 | 50 Posted May 08, 2009 12:12pm EDT by Aaron Task in Newsmakers,
Results of the stress test brought a collective sigh of relief from
Washington D.C. to Wall Street Friday, and stocks were rallying again on a
growing sense the financial crisis has past.
Don't you believe it, says William Black, an Associate Professor of
Economics and Law at the University of Missouri - Kansas City.
"It's in the interest of the financial community to send this propaganda out
," Black says. "It's remarkable not that th... 阅读全帖 |
|
