l**********1
发帖数: 5204 | 1 Bingo
it was from
更新时间： 2001-June-12
在美国当教授的北大毕业生(部分)
//www.gotopku.cn/data/detail.php?id=1974
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Recent 2007 database please try:
[八卦江湖] 带大家认识一下顶尖的美国华裔/华侨女科学家们（有PP有真相）
作者：第五哇 发表日期：2010-8-19
//www.tianya.cn/publicforum/content/funinfo/1/2195431.shtml
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only HHMI PI please go to
//bbs.netbig.com/thread-2113463-1-1.html
发表于 2011-11-18
NB: updated 2012-May-13
著名医学研究HHMI华裔/华侨PI科学家汇总
华裔/华侨 医学研究 HHMI, 科学家, 著名
Howard Hughes Medical Institute （HHMI） 是全球规模最大的非盈利性私立医学研
究所-基金会，拥资120忆，为美国第二大的慈善机构，仅次... 阅读全帖 |
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l**********1
发帖数: 5204 | 2 Johns Hopkins too 连tenure都过不了
不是看已有领域的挖掘 还要看新领域的digged out data and results.
please refer:
for example:
Lee Martin, Ph.D.
Professor of Pathology, Neuroscience
//pathology.jhu.edu/department/divisions/neuropathology/faculty-staff.cfm
his group recent paper:
线粒体上的控制 NO 的通道控制着细胞老化和自然死亡的过程
"The mitochondrial permeability transition pore regulates nitric oxide-
mediated apoptosis of neurons induced by target deprivation.” (2011)
J Neurosci. 31: 359-370.
PubMed link:
//www.ncbi.nlm.nih.gov/pubmed/2... 阅读全帖 |
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l**********1
发帖数: 5204 | 3 Viagra's false start
//resources.schoolscience.co.uk/pfizer/viagra/viagch2pg1.html
and
The Nobel Prize in Physiology or Medicine 1998
The Nobel Assembly at the Karolinska Institute in Stockholm, Sweden, has
awarded the Nobel Prize in Physiology or Medicine for 1998 to Robert F
Furchgott, Louis J Ignarro and Ferid Murad for their discoveries concerning
"the nitric oxide as a signalling molecule in the cardiovascular system".
//www.nobelprize.org/nobel_prizes/medicine/laureates/1998/illpres/
pl... 阅读全帖 |
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s******a
发帖数: 252 | 4 The golden age of metabolism is coming again.
The signaling roles of metabolites have been unappreciated for too long,
even prominent examples like cAMP are everywhere.
Stability and low concentration limit the study of many of them. We may know
less than half of metabolites in our body right now.
High resolution mass spectrometers and systems biology will power the next
wave of discoveries. The fist half of 20th century was the first golden age.
Pasted below are Nobel prizes related to metaboli... 阅读全帖 |
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s******a
发帖数: 252 | 5 The golden age of metabolism is coming again.
The signaling roles of metabolites have been unappreciated for too long,
even prominent examples like cAMP are everywhere.
Stability and low concentration limit the study of many of them. We may know
less than half of metabolites in our body right now.
High resolution mass spectrometers and systems biology will power the next
wave of discoveries. The fist half of 20th century was the first golden age.
Pasted below are Nobel prizes related to metaboli... 阅读全帖 |
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p*****c
发帖数: 20445 | 6 Christopher D. Lima, Ph.D.
Memorial Sloan-Kettering Cancer Center
Christopher Lima doesn’t pick easy problems. A structural biologist, he is
investigating how cells attach small proteins—like ubiquitin and the
related molecule SUMO—to other proteins to modify their function or fate.
Alongside those studies, he is exploring the molecular mechanisms that
underlie RNA processing and degradation—modifications to an RNA copy of a
gene that influence its stability and ability to be used as a template ... 阅读全帖 |
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d********0
发帖数: 534 | 7 各位老大，有一篇文章的全文想找一下，哪位能帮我下载一下，谢谢
Pain Res Manag. 2013 May-Jun;18(3):137-41.
Effects of hyperbaric oxygen on pain-related behaviors and nitric oxide
synthase in a rat model of neuropathic pain.
Han G, Li L, Meng LX. |
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r*********w
发帖数: 119 | 8 请好心人帮忙！我们学校没有购买这个杂志的access。
多谢！
我的邮箱是：i**********[email protected]
文献见下面（九篇）。多谢啦！
Peptide-Based Therapeutic Approaches for Treatment of the Polyglutamine
Diseases.
Takeuchi T, Popiel HA, Futaki S, Wada K, Nagai Y.
Curr Med Chem. 2014 Feb 17. [Epub ahead of print]
A Translational View of Peptide Treatment of Neurological Disorders.
Brinker T.
Curr Med Chem. 2014 Feb 17. [Epub ahead of print]
Davunetide: Peptide Therapeutic in Neurological Disorders.
Magen I, Gozes I.
Curr Med Chem. 2014 Feb 17. [Epub a... 阅读全帖 |
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b******3
发帖数: 377 | 9 【作者】Jong-Ho Kim , Daniel A. Heller , Hong Jin , Paul W. Barone ,
Changsik Song , Jingqing Zhang , Laura J. Trudel , Gerald N. Wogan ,
Steven R. Tannenbaum & Michael S. Strano
【文题】The rational design of nitric oxide selectivity in single-walled
carbon nanotube near-infrared fluorescence sensors for biological detection
【期刊名，年份，卷（期），起止页码】Nature Chemistry 1, 473–481 (1
September 2009) | doi:10.1038/nchem.332
【全文链接】http://www.nature.com/nchem/journal/v1/n6/pdf/nchem.332.pdf
【求助者联系方 |
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J***2
发帖数: 444 | 10 seems UK guy
papers little
1.J Neurochem. 2009 Apr;109(1):93-104. Epub 2009 Jan 19.
Differential sensitivity of oligodendrocytes and motor neurons to reactive
nitrogen species: implications for multiple sclerosis.
Bishop A, Hobbs KG, Eguchi A, Jeffrey S, Smallwood L, Pennie C, Anderson J,
Estévez AG.
2.J Neurochem. 2009 Apr;109(1):74-84. Epub 2009 Jan 13.
Mitigation of peroxynitrite-mediated nitric oxide (NO) toxicity as a
mechanism of induced adaptive NO resistance in the CNS.
Bishop A, Gooch |
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x****h
发帖数: 300 | 12 A note on the equilibrium relationship between ammonia and nitric acid and
particulate ammonium nitrate
Atmospheric Environment (1967), Volume 13, Issue 3, 1979, Pages 369-371
A.W. Stelson, S.K. Friedlander, J.H. Seinfeld
Please send to x******[email protected]
Thanks a lot! |
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l******i
发帖数: 2284 | 13 http://www.sciencedirect.com/science/article/pii/S1286457907001
Microbes and Infection
Volume 9, Issue 8, July 2007, Pages 981-987
Metabolism of nitric oxide by Neisseria meningitidis modifies release of NO-
regulated cytokines and chemokines by human macrophages
Tânia M. Stevanina, Corresponding Author Contact Information, E-mail
The Corresponding Author, Jay R. Lavera, Robert K. Pooleb, James W.B. Moirc,
Robert C. Reada |
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S*****n
发帖数: 6055 | 14 reflux with nitric acid |
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p*****s
发帖数: 15 | 16 Did you try pickling in a heated solution of sulfuric and nitric acids (70 +
70 g/l) with the addition of 5–6 g/l of fluoride. |
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R******d
发帖数: 5739 | 18 the sulfuric acid acidifies nitric acid to nitronium ion and water, i guess
the acetic acid pushes the equilibrium to the nitronium side |
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r*********w
发帖数: 119 | 19 请好心人帮忙！我们学校没有购买这个杂志的access。
多谢！
我的邮箱是：i**********[email protected]
文献见下面（九篇）。多谢啦！
Peptide-Based Therapeutic Approaches for Treatment of the Polyglutamine
Diseases.
Takeuchi T, Popiel HA, Futaki S, Wada K, Nagai Y.
Curr Med Chem. 2014 Feb 17. [Epub ahead of print]
A Translational View of Peptide Treatment of Neurological Disorders.
Brinker T.
Curr Med Chem. 2014 Feb 17. [Epub ahead of print]
Davunetide: Peptide Therapeutic in Neurological Disorders.
Magen I, Gozes I.
Curr Med Chem. 2014 Feb 17. [Epub a... 阅读全帖 |
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x****h
发帖数: 300 | 22 Role of WO3 in mixed V2O5-WO3/TiO2catalysts for selective catalytic
reduction of nitric oxide with ammonia
Applied Catalysis A: General, Volume 80, Issue 1, 2 January 1992, Pages 135-
148
J.P. Chen, R.T. Yang
thanks a lot |
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b****o
发帖数: 169 | 23 on a hot summer day, a marathon runner experinces cutaneous vasodilation to
help cool his body. this process is triggered in part by nerve impulses that
release chemical mediators that act on smooth muscle cells in blood vessel
walls. which of the following enzymes would be directly acivated by this
chemical mediator?
A adenylate cyclase
B guanylate cyclase
C heme oxygenase
D Nitric oside synthase
E phospholipase C |
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b****o
发帖数: 169 | 24 I also chose A because I thought it talks about NE and beta2 stimulation.
but the answer is B talking about nitric oxide. i don not know what's wrong
about A. anyone knows? |
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A*******s
发帖数: 9638 | 25 来自主题: MedicalCareer版 - 要上庭了 一直以为你的ID Dr.No 是 Dr.Nitric Oxide（NO)， 今天才明白是Nope， 看照片不
像是说Nope的啊？呵呵 |
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i**********d
发帖数: 853 | 26 35. Coronary blood flow is studied in an animal model of ischemic heart
disease. In this model, coronary blood flow is normal when the animal is at
rest, but when the animal becomes active coronary vasoconstriction occurs
and coronary blood flow decreases. The most likely cause of the observed
vasoconstriction is the action of which of the following on vascular smooth
muscle?
A. Adenosine
B. Nitric oxide
C. Norepinephrine
D. Oxygen
E. Prostacyclin
我们组的人讨论了半天，还是没有一个明确的结论；查了网上，也是众说纷纭。请高手
指点！！ |
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m***n
发帖数: 266 | 27 中医黑们怎么看?
比如方博士?
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics.
Lundberg, Jon O.; Weitzberg, Eddie; Gladwin, Mark T.. Nature Reviews Drug
Discovery, Feb2008, Vol. 7 Issue 2, p156-167 |
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r******0
发帖数: 2753 | 28 【产品名称】美国好时威心康信使一氧化氮胶囊
【英文名称】Healthway PRENOREX Nitric Oxide
【主要成份】L-精氨酸、L-瓜氨酸、柠檬酸钙、锰、绿茶提取物、硫氨酸、纤维素、维
生素C、
维生素E及叶酸等。
【规格】有效成分(L-精氨酸:800mg/粒*60粒/瓶*2瓶/盒)
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
I copied from the website you gave. Got it now? |
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h*******o
发帖数: 4884 | 29 First of all, it is not a 药
It is a dietary supplement, which means it does not have any treatment
efficacy.
Go to GNC you will get much better products.
And get a few fish oil with CoQ10, that's better dietary regimen for
cardiovascular health than Nitric oxide related product.
Also, it is registered under some Chinese in Beverly Hills and the company is located in Pasadena.
我看了一下地址,好像和mitbbs上面长期挂广告的移民律师的办公楼在一起.... |
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h*******o
发帖数: 4884 | 30 How do u define efficacy?
And what kind of dietary supplement did u take?
Vitamins? Sure, it will benefit u.
Nitric oxide for your cardiovascular health? Probably not....
Resveratrol? Unless u take 1 bottle per meal, and who knows what will happen
if you get overdosed.
The best proven dietary supplements that work are vitamins.
Trust me, dietary supplement shall not have any disease claims and most of them do nothing more than placebo. |
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D*********t
发帖数: 140 | 31 Sigh! 这样的骗子多了去啦, 多想想.
下回就得说瑞士有名的BETA制药公司的新药XX... |
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s******p
发帖数: 111 | 32 take higher dose of Imdur |
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s********p
发帖数: 1319 | 33 近来很多人问这个药——普力诺，国内的广告也做得比较“火”，还看到广告中专门有
句话：“美国人都吃”！
一切“保健药”，一般啥子病都有好处（啥子病都治），但因为对啥子心血管疾病都有
好处，所以，不能代替处方用药和正规治疗！
NO的供体很多，除了硝酸酯类药外，食物中营养成分——蛋白质中的精氨酸，就是NO的
原始供体，人体一般不缺。
硝酸酯类,的确是通过NO释放而起作用，但是它主要是通过扩张静脉，减少回心血量，
降低心脏的容量负荷而起作用的。冠脉的扩张，所起的治疗作用，很小——应为在心绞
痛的前提下，代谢产物的刺激，已经对冠脉起了最大的扩张作用。
NO是通过旁分泌机制而起作用的，也就是，NO在体内跑不了多远就要被清除。还要依赖
于内皮细胞的完整性。所以，内皮细胞的完整性，才是治疗心血管疾病的一个基础——
所以，价廉物美的阿司匹林，才是心血管疾病现代治疗的基础。
我打个比方，外源性NO真的能起比较大的作用，对肺动脉高压的患者，象哮喘患者吸氧
一样，吸入NO不就行了吗？但事实不是这样。
“美国人吃”，包治百病、没有副作用的药，其实质和“珍奥核酸”等乱七八糟的东西
一样，没有治疗作用，更没有寻证医... 阅读全帖 |
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i*d
发帖数: 2640 | 35 保健品都没屁用，有用的话为啥不申请成正式的药物？
( |
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h*******o
发帖数: 4884 | 36 That is not necessarily the case.
For metabolic coupling, glia are largely glycolytic relative to neurons. Yet
, they provide substrates for OXPHOS in neurons. Glia covert glucose to
pyruvate, then to lactate, which is transported to neurons and converted
back to pyruvate to enter into the TCA cycle and OXPHOS.
For more details, read Pierre Magistratti's review on glia-neuron metabolic
corss talk reviews.
For anti-oxidant capacity, glia are far more resistant to nitric oxide and
other ROS. They ... 阅读全帖 |
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p****y
发帖数: 23737 | 37 科学家最近发现西瓜中富含扩张血管的化合物—— L-瓜氨酸，可以减少心肌梗塞和中
风的危险。研究发现每日喝一定量的西瓜汁可以使高血压病人的血压下降[注]。
英国有160万人患有高血压，使心梗和中风的死亡率双倍地增加。英国人每年死于心梗
和中风者达6万以上。
一氧化氮是能使血管内皮扩张的重要物质，西瓜种的L-瓜氨酸可以使血液中的一氧化氮
含量明显增加。美国科学家给患高血压的自愿者每日6克从西瓜种提取出的L-瓜氨酸。6
星期后，9名受试者的血压均有下降，而且无副作用。但是如果是吃西瓜，大约一个半
西瓜才可达到这种治疗剂量。
佛罗里达州立大学的Arturo Figueroa博士说：这项研究说明保健食品有扩血管作用，
有一些食物可以防止高血压的发生，从而避免心梗和中风。虽然研究刚刚开始，结果令
人鼓舞，为今后在更多的人群中研究打下了坚实的基础。
研究人员之一Bahram Arjmandi教授说：所谓保健食品是指那些能促进健康、或防止疾
病、或多或少含有内在营养成分的食物。
科学家指出桔黄色的西瓜中的L-瓜氨酸含量高于红西瓜。两种西瓜均富含维生素A、维
生素B6、维生素C和纤维。西瓜中还含有钾元... 阅读全帖 |
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N***i
发帖数: 2063 | 38 我找到的，和大家共享. 你们出去购物的，花了那么多钱，回来花点包子，发给我，也
不错.
Chemicals Industry Outlook & Review
OUTLOOK
After the sharp declines in the last two years, we expect worldwide chemical
production (excluding pharmaceuticals) to recover, albeit at a slow rate.
At a global level, we currently expect that chemical production will require
another couple of years to return to production levels seen before the
crisis. In industrialized countries, severe declines in production as a
result of the global financial and econom... 阅读全帖 |
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f****w
发帖数: 947 | 39 这是我们这个星期收到的四个EB1/2的批准中的二个。明显的Vermont的批准有增快的趋势
，因为我们二个星期共有12个EB1/2从Vermont批准,2个从Texas,4个从NE及CA来。但是还
是有一大堆的案子在pending当中。
Ph.D. Material Science. Thermodynamic properties of the ternary and quaternary
metallic glasses, stability of the nuclear materials. 8 publications. 6
recommendation letters. NIW, Vermont 14 months, No RFE.
Ph.D. Physiology. Specializing in neurodegenerative disorders, neurogenesis
and neuron plasticity. Breakthrough discovery that Nitric Oxide promotes
neurogensis is vitally im |
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