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全部话题 - 话题: indole
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z**n
发帖数: 22303
1
【 以下文字转载自 WaterWorld 讨论区 】
发信人: zoun (zoun), 信区: WaterWorld
标 题: 全球35年科研铁证 癌症与肉食如影随行
发信站: BBS 未名空间站 (Sat Dec 24 12:01:04 2011, 美东)
全球35年科研铁证 癌症与肉食如影随行
新华网 2011-12-09 21:24:32
1976年,美国成立由参议员乔治麦高文主持的“营养与人类需要”小组,调查结果
显示:以肉食为主的饮食引发的癌症占了超过一半。
1980年,美国国家癌症研究院指派国家科学研究委员会进行食物营养与癌症有关文
献的收集和研究。研究报告指出:男性的癌症有四成由肉食引起;女性的癌症高达六成
与肉食有关。
多国科研机构证实:肉食摄入越多,罹患癌症尤其是消化系统癌症的机率越高
美国哈佛大学公共卫生专家马克马洪博士亦称,人类所患的七成癌症均与肉食有关。
美国国立健康学院研究过五万名素食者,发现他们与肉食者相较,得癌症的比例要
低很多。
美国丹佛市科罗拉多大学健康科学中心预防医学教授提姆拜耳说:“水果和蔬菜对
所有肠胃癌和吸烟引起的癌症有预防作用,这点... 阅读全帖
s**********e
发帖数: 2888
2
我觉得很多药物的失败都是安全性的问题,没有效果的药物也就是卖给别人一个没有用
的东西, 安全性有问题的就比较的可怕,尤其最近FDA开始更加严格的审查安全性问题
。你作了很多的实验,发现了非常好的lead compound或者已经优化了结构,但是离真
正有药厂愿意做临床距离还很遥远,因为极其可能出现的安全性问题会枪毙掉这个分子。
上次看到UC-Davis发表的一个food health initiative,我觉得来自于食品的小分子也
许是个比较可行的方向。食品中的分子,理论上毒性安全性的问题不会太大,比较人类
已经各种剂量使用了这么多年,虽然还需要实验来证明。你只要细胞动物实验很不错(
这个是你在实验室可以控制的),就有很大的可能可以继续做临床实验,成功的机会会
大很多。你不一定非要做药,你也可以开发成为保健,营养,食品添加剂,等等。我觉
得很多的例子,比如花菜中的sulforaphane,indole-3-carbinol,大蒜中的s-
allylmercaptocysteine,牛肉中发现的conjugated linoleic acid,最有名的当然是维
生素,比如维生素D,上次
r****1
发帖数: 2299
3
来自主题: Chemistry版 - NMR的问题
做了一个小分子的合成物,LC/MS看上去不错,但是NMR做出来不对,我对NMR不太熟悉
,大致上看看CHEMDRAW上给的图,反正就不像。感觉太干净了,只有四个单峰,我的合
成物里一个苯环,一个INDOLE环,不可能这样吧。
到底是怎么回事呢?
n*****a
发帖数: 1842
4
来自主题: Chemistry版 - NMR的问题
如果你讲的是氢谱,苯环加INDOLE环,若还有取代,可不就是只有几个光棍峰嘛。 你
是不是用chemdraw把目标化合物画出来然后check它的nmr模拟图呀?那不能当你的谱的
,连参考都算不上。
p****r
发帖数: 35
5
来自主题: Chemistry版 - 求文献, 多谢
Catalytic arylations with challenging substrates: from air-stable HASPO
preligands to indole syntheses and C-H-bond functionalizations.
Ackermann, Lutz.
Synlett (2007), (4), 507-526.
Air- and moisture-stable secondary phosphine oxides as preligands in
catalysis. Ackermann, Lutz.
Synthesis (2006), (10), 1557-1571
请发到 w*****[email protected]
多谢!
s**c
发帖数: 34339
6
PROGRESS IN THE FISCHER INDOLE REACTION. A REVIEW
http://www.sendspace.com/file/qb3ytg
e****2
发帖数: 2723
7
其实都是夸张
PHIl BARAN 的最近合成的那个OLIGO INDOLE 真没啥稀奇
不懂为啥发了这么多JACS
我请他收我当薄厚, 竟然被拒,真不懂
e****2
发帖数: 2723
8
其实都是夸张
PHIl BARAN 的最近合成的那个OLIGO INDOLE 真没啥稀奇
不懂为啥发了这么多JACS
我请他收我当薄厚, 竟然被拒,真不懂
c******n
发帖数: 16403
9
来自主题: Chemistry版 - 求文献
Tan, Min-Jia; Yin, Chun; Tang, Chun-Ping; Ke, Chang-Qiang; Lin, Ge; Ye, Yang
Antitussive Indole Alkaloids from Kopsia hainanensis
Planta Med 2011; 77: 939-944
DOI: 10.1055/s-0030-1250631
thanks!
d*****3
发帖数: 65
10
来自主题: Chemistry版 - paper help!
1. Wu, Zhimeng; Guo, Zhongwu. Sortase -Mediated Transpeptidation for Site-
Specific Modification of Peptides, Glycopeptides, and Proteins. J.
Carbohydrate Chem.2012, 31(1): 48-66.
http://www.tandfonline.com/doi/pdf/10.1080/07328303.2011.635251
2. Oh, Ki-Bong; Mar, Woongchon; Kim, Sanghee; Kim, Ji-Yun; Lee, Tae-Hoon;
Kim, Jae-Gyu; Shin, Daehyun; Sim, Chung J.; Shin, Jongheon. Antimicrobial
activity and cytotoxicity of bis(indole) alkaloids from the sponge
Spongosorites sp. Biological & Pharma... 阅读全帖
R******d
发帖数: 5739
11
butyric acid, methyl indole
j******2
发帖数: 665
12
最近老板找人合成了一个化合物,只有名字和结构,居然没有分子量。我老的有机化学
早忘光了!请帮忙算一下。谢谢了!
名称是 NNN-trimethyl-2-4-methyl-2-4-methyl-1H-indol-3-ylthiopentano。
结构见附图。
不胜感谢!!
c**y
发帖数: 377
13
【 以下文字转载自 Chemistry 讨论区,原文如下 】
发信人: cony (defense 惶恐中), 信区: Chemistry
标 题: An Organic mechanism question (urgent)
发信站: The unknown SPACE (Mon Jun 16 21:41:01 2003) WWW-POST
Electrophilic substitution mechanism for indole ring?
Anyone knows a bit detail about what is the most stable transition state?
Thx a lot!!!!!
l****7
发帖数: 148
14
来自主题: MedicalCareer版 - Step2 Daily Question
I am confused, the following is the answer I got:
The correct answer is C. It is generally accepted that the blood supply from
1978 to 1985 was likely to be tainted with HIV positive blood. For this
reason, as well as the indolent nature of HIV infection, patients with a
history of blood transfusions during these years, even if currently
asymptomatic, should be screened.
Testing for hepatitis B (choice A) or hepatitis C (choice B) would not be
incorrect, but there are no formal guidelines recomm
J*********4
发帖数: 1274
15
来自主题: MedicalCareer版 - 妈妈慢淋,求建议
It seems that your mother's disease is indolent
Assume your mother was asymptomatic before the treatment, no weight loss,
low fever, no loss of appetite, no enlargement of lymphonodes, no enlarged
spleen
If her lymphocyte count <30,000/microL, blood lymphocyte doubling time >12
months, hemoglobin ≥13 g/dL, her survival statistics could be similar to
those of an age and sex-matched group.
For 慢淋, even extreme increased lymphocytosis, without symptoms or impaired
bone marrow function such as anemi... 阅读全帖
T*R
发帖数: 36302
16
来自主题: Pharmaceutical版 - 未来的十年,做药的春天!
if you look at CDC/ACS/...'s guidline, you will see significant changes in
last 2 years, for example: PSA screen, mammogram screen....
WE ALL KNOW WHY THEY CHANGED GUIDELINE, THE ONLY REASON IS SAVING
HEALTHCARE COST.
The AUA recommends against screening in men under age 40. Such blanket
recommendations can increase the risk of younger men being overlooked and
potentially resulting in worse disease later in life. Men under 40 need to
be educated about prostate cancer and given a clear understan... 阅读全帖
T*R
发帖数: 36302
17
来自主题: Pharmaceutical版 - 未来的十年,做药的春天!
if you look at CDC/ACS/...'s guidline, you will see significant changes in
last 2 years, for example: PSA screen, mammogram screen....
WE ALL KNOW WHY THEY CHANGED GUIDELINE, THE ONLY REASON IS SAVING
HEALTHCARE COST.
The AUA recommends against screening in men under age 40. Such blanket
recommendations can increase the risk of younger men being overlooked and
potentially resulting in worse disease later in life. Men under 40 need to
be educated about prostate cancer and given a clear understan... 阅读全帖
I****a
发帖数: 407
18
来自主题: Medicalpractice版 - 肝功能ALT,ALP,淋巴细胞长期偏高 (转载)
I do not know what exactly the liver/spleen scan means but I assume they
want to make sure you do not have some sort of indolent lymphoma. What is
the result of flow cytometry of your peripheral blood?
l**********g
发帖数: 426
19
来自主题: Medicalpractice版 - 肝功能ALT,ALP,淋巴细胞长期偏高 (转载)
30岁有可能indolent lymphoma吗?
flow cytometry is essentially unremarkable. (bone marrow test)
I****a
发帖数: 407
20
来自主题: Medicalpractice版 - 参加[文献阅读活动] CT Lung cancer screen
This is an exciting trial. Basically for the first time, a well designed
prevention trial demonstrated the reduction of lung cancer related mortality
and all cause mortality. Many trials in the past failed to do this, the
most recent one was PLCO trial using chest x ray as screening method. The
number need to treat to prevent 1 death is between 200-300 which is much
better than mammogram and colonoscopy. I believe those number is around 1000
. Given the success, I believe NCCN ( National Compreh... 阅读全帖
I****a
发帖数: 407
21
来自主题: Medicalpractice版 - 参加[文献阅读活动] CT Lung cancer screen
PSA is a very good and sensitive test to detect known prostate cancer
relapse. It is also a ok test to gauge the treatment effect.
However it is a lousy test for screening asymptomatic male. Prostate cancer
incidence exploded after PSA screening was adopted in the 90s however a
handful of US trials did not show survival benefit after long follow up. In
other words, we diagnose and treat a lot of biological indolent tumors that
otherwise will not bother those men in their life time. I believe USP... 阅读全帖
s*****p
发帖数: 5342
22
来自主题: _DC版 - 做生物的,化学的请进
能帮俺搞点
3-吲哚乙酸(简称吲哚乙酸,英文名Indole-3-acetic acid,缩写IAA)
http://zh.wikipedia.org/wiki/3-%E5%90%B2%E5%93%9A%E4%B9%99%E9%85%B8
1-萘乙酸 (1-Naphthaleneacetic acid),簡稱NAA
http://zh.wikipedia.org/wiki/1-%E8%90%98%E4%B9%99%E9%85%B8
看上去,都是些实验室就该有的原料.至少合成吲哚乙酸不难.sigh, 远离lab多年了,现
在都得求人了.:)
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