H**********J
发帖数: 351 | 1 Primary Responsibilities and Accountabilities:
On the ED Core Team
• Represents medical science on ED Teams to
o ensure alignment on strategy between ED and LIP Criteria
o support target and clinical candidate selection (in collaboration with
Clinical Pharmacologist)
o provide guidance on benefit/risk assessment and risk mitigation
activities (responsibility shared with Clinical Pharmacologist)
• Is accountable for the overall design and the clinical and
scientific c... 阅读全帖 |
|
W*****6
发帖数: 2 | 2 Please drop a note if you see fit. Thanks.
Requisition ID: WD20816
Position: Full time
Open date: Mar 11, 2015 5:30:58 PM
Functional area: Science and Technology
Location: Collegeville, Pennsylvania
Required degrees: Bachelor's Level Degree
Experience required: 5 years
Relocation: No
Basic qualifications:
• BS with >5yrs or M.S. with >3yrs experience in cancer biology,
cancer immunology or related field
• Extensive knowledge of and experience in phenot... 阅读全帖 |
|
W*****6
发帖数: 2 | 3 【 以下文字转载自 Biology 讨论区 】
发信人: WD20816 (WD20816), 信区: Biology
标 题: GSK job opportunity
发信站: BBS 未名空间站 (Fri Mar 27 20:18:34 2015, 美东)
Please drop a note if you see fit. Thanks.
Requisition ID: WD20816
Position: Full time
Open date: Mar 11, 2015 5:30:58 PM
Functional area: Science and Technology
Location: Collegeville, Pennsylvania
Required degrees: Bachelor's Level Degree
Experience required: 5 years
Relocation: No
Basic qualifications:
• BS with >5yrs or M.S. with... 阅读全帖 |
|
发帖数: 1 | 4 07 Nov 2019
Just as the clamor about Biogen’s seeking FDA approval for aducanumab with
one positive Phase 3 trial started to die down, a Chinese company garnered a
regulatory thumbs-up for its drug, also with one Phase 3 trial. On November
2, Shanghai Green Valley Pharmaceuticals announced that China’s National
Medical Product Administration (NMPA) had conditionally approved GV-971, aka
oligomannate, for the treatment of mild to moderate Alzheimer’s disease.
Full approval, expected to come in sp... 阅读全帖 |
|
m****s
发帖数: 18160 | 5 【 以下文字转载自 Biology 讨论区 】
发信人: BachCello (cello), 信区: Biology
标 题: Postdoc positions in Weill Cornell medical college
发信站: BBS 未名空间站 (Mon Jul 29 16:32:52 2013, 美东)
Description
POSTDOCTORAL POSITION – Hematopoietic Stem Cell Biology
Weill Cornell Medical College, Cornell University, New York, NY
A postdoctoral position is available to investigate mechanisms controlling
hematopoietic stem cell (HSC) quiescence and how disruption of these
mechanisms contributes to the pathogenesis of hematopoietic m... 阅读全帖 |
|
m****s
发帖数: 18160 | 6 【 以下文字转载自 Postdoc 讨论区 】
发信人: mummy (老菜皮), 信区: Postdoc
标 题: postdoc position in NYC
发信站: BBS 未名空间站 (Thu Sep 26 10:42:03 2013, 美东)
朋友招postdoc，帮他贴广告，有兴趣的可以申请， 如果贴错地方请帮忙转到正确的
地方，谢谢
Description
POSTDOCTORAL POSITION – Hematopoietic Stem Cell Biology
Weill Cornell Medical College, Cornell University, New York, NY
A postdoctoral position is available to investigate mechanisms controlling
hematopoietic stem cell (HSC) quiescence and how disruption of these
mechanisms contributes to the pathogenesis of ... 阅读全帖 |
|
B****n
发帖数: 11290 | 7 這篇文章還挺有點統計分析的味道
近些年科學家做的一件事就是看大腦裡的biomarker和心里阿 疼痛感阿 各樣認知功能
等的關係
我前幾天聽了一個演講挺有意思 他是研究大腦裡和疼痛感有關的biomarker
但是他研究的是physical pain (thermal pain) 但科學家發現這種physical pain和
mental pain發生的區域(或是biomarker)是在同樣的地方 這時候如何能區分你是因為
受熱傷害(thermal pain)
還是你去看醫生的時候發現醫療帳單好貴 還是情人節被dump引發的pain就很不容易 |
|
R****n
发帖数: 708 | 8 MD老板面试后，发给我两篇关于biomarker的guideline,一个是讲整个biomarker领域从
sample preparation,standardize analytical method and communication between
different research groups.另一篇是说biomarker report怎么写的.看完之后也没什
么感觉。
老板问两个问题一个是如何评价一个marker对于病人treatment的影响？如果有一个
marker怎么validate? 结果哑口无言。以前只是在意用什么方法检测，这两个问题问的
我一点想法都没有。牛人给说说思路吧，是不是一些统计方面的比较么？ |
|
A*****n
发帖数: 243 | 9 不觉得这篇文章有那么轰动的意义。看了一下他们的方法，他们并不是用单个基因的信
息，而是100个基因做了PCA之后的PC１，很大程度上已经抹去了很多随机的因素，如果
有时间的话可以算一下100个基因的PC１和全基因组的PC1，说不定相关程度更大，这样
100个基因已经包含了很多的信息，具有一定的分类效果也就不奇怪了。其次本来
biomarker就不一定和机制有什么密不可分的联系，有些就是用来对病人进行分型，或
者预测治疗预后的，也早已经有很多报道表明不同的基因组合可以实现相同的分类性能
。但是如果都能实现较好的分类效果，并且基因数目相对较好的话，就已经可以达到
biomarker的目的啦。本来biomarker就是从实用性出发，而不应该包含太多因果的概念
在里面。就像癌症数据，找了那么mutation，而要找出driver mutation还是很不容易
，但并不代表找到的mutation没有意义了。 |
|
A*****n
发帖数: 243 | 10 首先他们做完PCA之后就不再是完全的随机了，就像上面说的microarray数据一来，直
接做个PCA，实际上就能做到很好的效果了。之所以作biomarker的研究就是希望能够用
尽量少的基因数实现同样的目的。想象一下有个完美的基因，同时还有100个基因的表
达模式和其高度相关，不同的方法会选出这100个里面中间的一个。这个时候，方法没
有什么重大缺陷，基因也没有错，每个也都能作为一个很好的biomarker。错的其实就
是有些人在希望这个基因有很好分类性能的同时，还希望证明这个特定的基因和机制有
关系，这就相当于对biomarker寄予了太高的要求。 |
|
A*****n
发帖数: 243 | 11 不觉得这篇文章有那么轰动的意义。看了一下他们的方法，他们并不是用单个基因的信
息，而是100个基因做了PCA之后的PC１，很大程度上已经抹去了很多随机的因素，如果
有时间的话可以算一下100个基因的PC１和全基因组的PC1，说不定相关程度更大，这样
100个基因已经包含了很多的信息，具有一定的分类效果也就不奇怪了。其次本来
biomarker就不一定和机制有什么密不可分的联系，有些就是用来对病人进行分型，或
者预测治疗预后的，也早已经有很多报道表明不同的基因组合可以实现相同的分类性能
。但是如果都能实现较好的分类效果，并且基因数目相对较好的话，就已经可以达到
biomarker的目的啦。本来biomarker就是从实用性出发，而不应该包含太多因果的概念
在里面。就像癌症数据，找了那么mutation，而要找出driver mutation还是很不容易
，但并不代表找到的mutation没有意义了。 |
|
A*****n
发帖数: 243 | 12 首先他们做完PCA之后就不再是完全的随机了，就像上面说的microarray数据一来，直
接做个PCA，实际上就能做到很好的效果了。之所以作biomarker的研究就是希望能够用
尽量少的基因数实现同样的目的。想象一下有个完美的基因，同时还有100个基因的表
达模式和其高度相关，不同的方法会选出这100个里面中间的一个。这个时候，方法没
有什么重大缺陷，基因也没有错，每个也都能作为一个很好的biomarker。错的其实就
是有些人在希望这个基因有很好分类性能的同时，还希望证明这个特定的基因和机制有
关系，这就相当于对biomarker寄予了太高的要求。 |
|
o*****m
发帖数: 981 | 13 我觉得在你判断别人文章水的时候，是否真正理解了别人的文章？
这篇文章指出在现有的biomarker 研究中，利用survival证明他们找到的biomarkers具
有生物意义这个方法是不正确的。
如果只是用predicting survival就说明这个gene signantures是重要的biomarker的话
。我随便设计一个乱七八糟的实验，找到一组差异基因，然后预测一下survival，就说
我找到的差异基因是有意义的话。那正如曹操所说：不知天下几人称王几人称帝！
另外现在多数研究都是找研究中的差异基因，并不是所谓的driver，这些基因，我相信
多数是passenger gene，而不是driver。 Driver基因可能需要通过mutation，copy
number等去寻找，而现有的gene signantures多数都是differentially expressed
genes。
也就是说你假设的那些driver 根本就是不存在或者很稀少的。
殊不知，多少paper是就拿两种样本比比，找点差异基因，然后找个独立的数据预测一
下，然后忽悠说多么有意义。
真不敢科学竟然... 阅读全帖 |
|
m****e
发帖数: 489 | 14 Clin Investig (Lond). 2011 Dec;1(12):1629-1636.
Design of clinical trials for biomarker research in oncology.
Mandrekar SJ, Sargent DJ.
J Clin Oncol. 2009 Aug 20;27(24):4027-34. Epub 2009 Jul 13.
Clinical trial designs for predictive biomarker validation: theoretical
considerations and practical challenges.
Mandrekar SJ, Sargent DJ.
J Clin Oncol. 2005 Mar 20;23(9):2020-7.
Clinical trial designs for predictive marker validation in cancer treatment
trials.
Sargent DJ, Conley BA, Allegra C, Collett... 阅读全帖 |
|
|
b****r
发帖数: 17995 | 16 公司的R&D，活到进入市场的可能1/10? 进入市场后，能活过2年的可能又只有1/10?
对于大公司来说，100个R&Dproject同时运行，成功的可能性是很大的。但是对于小lab
甚至个人呢？
我是做临床出生的，我觉得我看问题的角度和这个帖子大部分不一样。如果你们是想从
临床赚钱，第一个不是应该看paper，或者听这些基础科学家们吹，你们应该多听听临
床医生们的需求，了解一下临床医生的水平和order test之前的思路，看看临床上的证据
当然，我完全同意NGS将会是将来临床诊断的一大支柱。但是具体到lz所问的个人发展
，就要具体到很细节的方向。只有极少数NGS相关的方向会在今后10年内真正在临床上
开花结果，其他做NGS的也未见得有什么好日子过，更别说转方向付出的代价了
打个比方， RNA seq做biomarker，其实类似的array data也不是质量差那么多，这也
10多年了，临床上谁用了？没有人用我觉得并不奇怪，临床上目的很简单，最重要的是
要能治疗，改善预后。哪怕是预防或者提供预后线索，虽然社会意义是有，但是一样不
会有多少病人掏钱。人性的弱点在那里。要改善治疗，这名... 阅读全帖 |
|
T**N
发帖数: 129 | 17 这是真的么
October 11, 2013
Faulty Antibodies Continue to Enter US and European Markets, Warns Top
Clinical Chemistry Researcher
By Adam Bonislawski
One year after alerting the proteomics community to a Chinese life sciences
company that he said had infiltrated the US and European markets with faulty
antibodies, researcher Nader Rifai told ProteoMonitor this week that the
rogue firm is still at it.
Rifai, director of clinical chemistry at Children's Hospital Boston, first
warned of the faulty antibod... 阅读全帖 |
|
p*******e
发帖数: 3 | 18 Scientist / Senior Scientist, Next Generation Sequencing
OncoDiagnostics Technologies - San Francisco, CA
Job ID: 00001
Who We Are
OncoDiagnostics Technologies is a Silicon Valley-based biotech start-up
company focusing on precision diagnostics and medicine in cancer and other
serious illnesses. We aim to provide innovative non-invasive diagnostic
tests to enable precision medicine. At OncoDiagnostics, we believe that
people are our most vital assets and we are dedicated to creating a great
plac... 阅读全帖 |
|
w********g
发帖数: 447 | 19 这个我就更加不理解了。说血液检测不到marker，浓度太低，这个算事实。但是提出的
解决的办法就是把肿瘤切一块，然后imaging。既然你已经把肿瘤切下来了，那还用得
着你imaging干嘛。找biomarker，事先都已经知道或者定义了“区别”的存在（一半肿
瘤，一半正常组织），然后你要寻找biomarker去和这个“区别”关联上。那直接显微
镜观察一下切一刀，一半有肿瘤的，一半没肿瘤的，然后萃取，上LC/MS就行啦。样品
处理啥的比imaging的样品制备靠谱多了，数据更加可信，花的实验时间可能是imaging
实验的几十分之一。回头两个比对一下，不是一样找得出biomarker吗？你折腾了半天
，花了无数的时间制备imaging样品，最后得到了啥额外的LC/MS得不到的信息呢？ |
|
L****r
发帖数: 333 | 20 研究就是尝试不同的方法，从另外一个角度看问题，新方法容易发文章， 拿项目，
况且MALDI Imaging和LCMS各有千秋。
MALDI Imaging可以看到biomarker在组织里的真实分布，其萃取是利用溶解matrix的溶
剂（乙晴或者甲醇）在组织表面上直接进行的，找biomarker其实就是直接对比肿瘤和
健康组织的差异，如果在同一块板上同时扫描它们，结果很直接， 根据颜色深浅就能
判断。而LCMS的组织萃取，是用溶剂将蛋白沉淀，其实蛋白很难完全沉淀掉，然后真空
干燥除溶剂，然后做LCMS,biomarker特性有无变化，还真说不定。况且肿瘤和健康组织
分开处理， 分开进样， 容易引进误差， 比如样品处理，柱子性能的变化等。 |
|
z**4
发帖数: 37 | 21 Title:
Candidate proteomic biomarkers for non-alcoholic fatty liver disease (
steatosis and non-alcoholic steatohepatitis) discovered with mass-
spectrometry: a systematic review
Journal: Biomarkers
Biomarkers. 2015 Dec 3:1-13. [Epub ahead of print]
I will send you "Bao Zi".
Scott |
|
t*b
发帖数: 850 | 22 http://lunainc.com/about-luna/careers/jobs/
Research Scientist , Danville
Location: Danville, VA
Job Code: 88
# of openings: 1
Description
Role/Responsibilities:
The nanomaterials group is seeking a Research Scientist in our Danville, VA
location to support a number of programs involving the development of in
vitro molecular diagnostic assays and biosensors. Luna owns and operates a
nanomaterial manufacturing facility, conducts innovative research and
develops novel nanomaterial tec... 阅读全帖 |
|
c******r
发帖数: 889 | 23 生物学的进展就是机理上的进展。基础于此，医学能更有的放失的进步。
再举一个例子：biomarker。癌症最好的治疗手段依然是早期发现。有了机理研究，在
分子水平的了解，就有可能发现比较容易检测的特异的，灵敏的biomarker.这样帮助早
期发现癌症病例，每年能拯救的生命是很可观的。
最近NATURE上前列腺癌的BIOMARKER就是一个例子。
再比如我们实验室发现（通过MICROARRY，BIOSTAT）一个基因表达水平和肺癌复发正相
关，这就能帮助临床医生在治疗时能针对性的决定是否在术后化疗。提供好的OUTCOME。
乳腺癌依据GENETIC MARKER的不同分类（ER+，HER2+。。。ETC），他们对各种药物的
反应是不同的，治疗方案当然要依据分型来决定。有针对性帮助病人延长生命。
这些都是例子，生物学提供基础/机理的研究结果，直接应用到临床。
不明白你割裂医学和生物学的出发点。
其实，医学是应用科学，就是基础于各学科的发展的。 |
|
b***8
发帖数: 60 | 24 In biomarker studies, the ultimate goal is to screen dozens, or
hundreds, or potentially hundreds of thousands of potential predictors
using explanatory methods to understand the existing data and then
ultimately identify a factor or set of factors that could be
used in the prediction of new observations with high accuracy. While
the concepts of "association testing" and "classification" are not
unrelated in this scenario, they are inherently separate objectives
requiring the implementation of d... 阅读全帖 |
|
d*********r
发帖数: 297 | 25 Fresh STAT. Master 找工，求内推等等。
今年12月应用统计硕士毕业，F1 +opt.
本人基本技能：
a) Having fair experience in ANOVA Analysis, Linear modeling, Logistic
modeling, Survival data and longitudinal data analysis etc.
b) Being good at SAS programming, working knowledge of R, Excel, Access and
Linux operation system administration and configuration. Knowledge of the
fundamental concepts, practices, and procedures used in computer
programming such as JAVA(JDK V.7u25).
c) Writing Statistical Analysis Plan, statistics report... 阅读全帖 |
|
l****y
发帖数: 486 | 26 House committee approves bill on speeding medical innovation
http://news.sciencemag.org/funding/2015/05/house-committee-appr
Jocelyn is a staff writer for Science magazine.
Email Jocelyn
By Jocelyn Kaiser 21 May 2015 5:30 pm 0 Comments
A major congressional effort to spur medical innovation passed another
milestone today when a House of Representatives committee signed off on the
21st Century Cures Act.
The bill, developed by representatives Fred Upton (R–MI) and Diana DeGette
(D–CO), revamps po... 阅读全帖 |
|
h********0
发帖数: 944 | 27 【 以下文字转载自 Pharmaceutical 讨论区 】
发信人: huiqiang80 (gene), 信区: Pharmaceutical
标 题: 在找工作，想跳槽的进来看看
发信站: BBS 未名空间站 (Fri Aug 9 00:50:28 2013, 美东)
老外朋友让我贴个JD， 感兴趣的联系我
Translational Clinical scientist
Person hired will serve a diverse role in translational research and
clinical development in the field of molecular diagnostics for cancer.
- Ph.D. with at least 5 years of experience in clinical research
and a background in molecular technology
- Previous experience as a clinical ... 阅读全帖 |
|
d*********r
发帖数: 297 | 28 Fresh STAT. Master 找工，求内推等等。
今年12月应用统计硕士毕业，F1 +opt.
本人基本技能：
a) Having fair experience in ANOVA Analysis, Linear modeling, Logistic
modeling, Survival data and longitudinal data analysis etc.
b) Being good at SAS programming, working knowledge of R, Excel, Access and
Linux operation system administration and configuration. Knowledge of the
fundamental concepts, practices, and procedures used in computer
programming such as JAVA(JDK V.7u25).
c) Writing Statistical Analysis Plan, statistics report... 阅读全帖 |
|
p******9
发帖数: 2 | 29 Job Description
Please send you CV to j******[email protected] if you interested.
Genomics Scientist
This position is based in Shanghai, China.
Duties and Responsibilities:
• Develop and validate PCR and Molecular diagnostic assays (including
both blood and tissue biomarkers) for Genomics projects.
• Participate in scientific activities and initiatives in support of
global Laboratory Operations in the Genomics Department.
• Participate in developing/identifying new strategies, techn... 阅读全帖 |
|
b**g
发帖数: 27 | 30 中国科学院纳米生物效应与安全性重点实验室招聘启事
高能物理研究所
基于光学技术的活细胞原位分析
岗位属性：研究人员（副研究员或助理研究员）
岗位数：1名
岗位职责：
活细胞内biomarker的原位分析：应用细胞分子生物技术，结合bioorthogonal
chemistry技术和高分辨光学显微技术，研究活细胞内biomarker的实时、原位运动信息
及其与细胞功能的关系。
岗位要求（专业背景，具一项就可）：
1、研究生毕业，年龄35岁以下；
2、专业背景：细胞分子生物学背景，熟悉高分辨光学显微技术和光学探针标记技术，
熟悉bioorthogonal chemistry技术手段。
3、能够独立从事科学研究，较好的数据分析能力，有较好的外语写能力；
应聘要求：
应聘者须提供以下材料：
1、 个人简历（包括代表性论文复印件）；2、 学历、学位证书复印件；
3、 推荐人的姓名和联系方式。
有意应聘者，请通过电子邮件邮寄报名材料到
联系人：
高学云 研究员 联系电话：010-88236709
E-mail：g***[email protected] |
|
f*********o
发帖数: 38 | 31 Company: Top Pharma
Location: Shanghai
Job title: Principle Scientist
Key job responsibilities:
• Provide strategic and tactical leadership in shaping
translational science in the R&I disease area
• Shape and lead a research team
• Build up laboratory capabilities to execute R&I disease area
studies
Minimum Requirements:
• MD or Ph.D with Medial background/training in biological science
with a minimum of 5 years experience in the pharmaceutical industry and/or... 阅读全帖 |
|
d*********r
发帖数: 297 | 32 Fresh STAT. Master 找工，求内推等等。
今年12月应用统计硕士毕业，F1 +opt.
本人基本技能：
a) Having fair experience in ANOVA Analysis, Linear modeling, Logistic
modeling, Survival data and longitudinal data analysis etc.
b) Being good at SAS programming, working knowledge of R, Excel, Access and
Linux operation system administration and configuration. Knowledge of the
fundamental concepts, practices, and procedures used in computer
programming such as JAVA(JDK V.7u25).
c) Writing Statistical Analysis Plan, statistics report... 阅读全帖 |
|
g****d
发帖数: 238 | 33 【 以下文字转载自 Biology 讨论区 】
发信人: gifted (sentosa), 信区: Biology
标 题: call for reviewers (转载)
发信站: BBS 未名空间站 (Wed Apr 5 23:38:57 2017, 美东)
发信人: gifted (sentosa), 信区: EB23
标 题: call for reviewers
发信站: BBS 未名空间站 (Wed Apr 5 21:03:58 2017, 美东)
OAP 旗下 International Journal of Clinical Microbiology，无分非SCI哦，稿件情
况如下：
Title: Transcription regulators MarA, SoxS and Rob and CTX-M beta-lactamase
gene sequences as potential diagnostic biomarker in monitoring and
management of antibiotic treatment
Abstract:
Abs... 阅读全帖 |
|
b*****p
发帖数: 9649 | 34 FDA tells Sarepta new drug filing for eteplirsen 'premature'
Sarepta provided an update on its discussions with the FDA regarding its
planned New Drug Application submission and confirmatory clinical study with
eteplirsen for the treatment of Duchenne muscular dystrophy. Citing recent
developments since Sarepta's last meeting with the agency, including a
failed study with a competitive product and recent natural history data in
DMD, the FDA indicated the new data raise "considerable doubt" about... 阅读全帖 |
|
g****d
发帖数: 238 | 35 【 以下文字转载自 EB23 讨论区 】
发信人: gifted (sentosa), 信区: EB23
标 题: call for reviewers
发信站: BBS 未名空间站 (Wed Apr 5 21:03:58 2017, 美东)
OAP 旗下 International Journal of Clinical Microbiology，无分非SCI哦，稿件情
况如下：
Title: Transcription regulators MarA, SoxS and Rob and CTX-M beta-lactamase
gene sequences as potential diagnostic biomarker in monitoring and
management of antibiotic treatment
Abstract:
Abstract
Extended Spectrum Beta Lactamases (ESBLs) are resistance enzymes that are
responsible for antibiotic resista... 阅读全帖 |
|
g****d
发帖数: 238 | 36 OAP 旗下 International Journal of Clinical Microbiology，无分非SCI哦，稿件情
况如下：
Title: Transcription regulators MarA, SoxS and Rob and CTX-M beta-lactamase
gene sequences as potential diagnostic biomarker in monitoring and
management of antibiotic treatment
Abstract:
Abstract
Extended Spectrum Beta Lactamases (ESBLs) are resistance enzymes that are
responsible for antibiotic resistance and are produced by the CTX-M beta-
lactamase gene in Gram-negative pathogens, such as antibiotic resistant
Escherichia ... 阅读全帖 |
|
g********s
发帖数: 31 | 37 Job Title
Research Assistant - Computational Statistics in Cancer Biomarker Discovery
Research Group
Onco-Proteomics Centre, Department of Biological Sciences, National University
of Singapore
Job Description
The post is aimed at developing and testing new computational statistics
methods for exploiting the large genomics and proteomics datasets that are
arising in cancer biomarker research involving different data mining
approaches (artificial intelligence application and multi-variant analyses |
|
g******o
发帖数: 33 | 38 老婆要去康州了，我也要过去。正在找工作。Pfizer在Groton的两个职位挺符合我的背
景。板上有没有在Pfizer的朋友能帮忙refer一下。如果能帮忙联系到hiring manager
就更好了。多谢了。
Biomarker Bioanalytical - Principle Scientist (R5) - Ligand Binding Job in
Groton Job Number: 83843
Flow Cytometry Senior Principle Scientist (R6) - Regulated Biomarkers Job in
Groton Job Number: 83844 |
|
h********0
发帖数: 944 | 39 Post for a friend
Translational Clinical scientist
Person hired will serve a diverse role in translational research and
clinical development in the field of molecular diagnostics for cancer.
- Ph.D. with at least 5 years of experience in clinical research
and a background in molecular technology
- Previous experience as a clinical scientist – designing clinical
studies incorporating biomarkers – preferred
- Familiarity with pathology and oncology and genomic app... 阅读全帖 |
|
j****y
发帖数: 1714 | 40 【 以下文字转载自 Running 讨论区 】
发信人: joyjoy (joy), 信区: Running
标 题: Extreme Endurance Exercise and heart attack
发信站: BBS 未名空间站 (Sat Oct 5 01:52:16 2013, 美东)
我有同事骑自行车突然心脏病发作死亡。所以看了看锻炼过度和心脏病的关联的文章。
仅供参考：
http://fitness.mercola.com/sites/fitness/archive/2013/08/23/ext
By Dr. Mercola
Do you dread going to the gym for what feels like hours at a stretch? Or do
you avoid working out altogether because you just don't have the time? Then
what I'm about to tell you should be music to your ears: when it comes to... 阅读全帖 |
|
b***i
发帖数: 10018 | 41 貌似这位美女也是有目的的...
http://www.vegsource.
com/news/2010/07/china-study-author-colin-campbell-slaps-down-critic-den
ise-minger.html
Reply to Denise Minger
by Dr. T. Colin Campbell, PhD, author The China Study
Ms. Denise Minger has published a critique of our book, The China Study,
as follows.
The China Study: Fact or Fallacy? by Denise Minger - article found at:
http://bit.ly/9s5pn8
It is both interesting and gratifying that there has been such a huge
response, both on her blog and on those of others... 阅读全帖 |
|
j****y
发帖数: 1714 | 42 【 以下文字转载自 Running 讨论区 】
发信人: joyjoy (joy), 信区: Running
标 题: Extreme Endurance Exercise and heart attack
发信站: BBS 未名空间站 (Sat Oct 5 01:52:16 2013, 美东)
我有同事骑自行车突然心脏病发作死亡。所以看了看锻炼过度和心脏病的关联的文章。
仅供参考：
http://fitness.mercola.com/sites/fitness/archive/2013/08/23/ext
By Dr. Mercola
Do you dread going to the gym for what feels like hours at a stretch? Or do
you avoid working out altogether because you just don't have the time? Then
what I'm about to tell you should be music to your ears: when it comes to... 阅读全帖 |
|
j****y
发帖数: 1714 | 43 【 以下文字转载自 Running 讨论区 】
发信人: joyjoy (joy), 信区: Running
标 题: Extreme Endurance Exercise and heart attack
发信站: BBS 未名空间站 (Sat Oct 5 01:52:16 2013, 美东)
我有同事骑自行车突然心脏病发作死亡。所以看了看锻炼过度和心脏病的关联的文章。
仅供参考：
http://fitness.mercola.com/sites/fitness/archive/2013/08/23/ext
By Dr. Mercola
Do you dread going to the gym for what feels like hours at a stretch? Or do
you avoid working out altogether because you just don't have the time? Then
what I'm about to tell you should be music to your ears: when it comes to... 阅读全帖 |
|
j****y
发帖数: 1714 | 44 我有同事骑自行车突然心脏病发作死亡。所以看了看锻炼过度和心脏病的关联的文章。
仅供参考：
http://fitness.mercola.com/sites/fitness/archive/2013/08/23/ext
By Dr. Mercola
Do you dread going to the gym for what feels like hours at a stretch? Or do
you avoid working out altogether because you just don't have the time? Then
what I'm about to tell you should be music to your ears: when it comes to
exercise, less is more.
It's becoming increasingly clear from the recent flurry of scientific
studies that overdosing on exercise can have detrimental... 阅读全帖 |
|
R*****s
发帖数: 41236 | 45 ☆─────────────────────────────────────☆
joyjoy (joy) 于 (Sat Oct 5 01:52:16 2013, 美东) 提到:
我有同事骑自行车突然心脏病发作死亡。所以看了看锻炼过度和心脏病的关联的文章。
仅供参考：
http://fitness.mercola.com/sites/fitness/archive/2013/08/23/ext
By Dr. Mercola
Do you dread going to the gym for what feels like hours at a stretch? Or do
you avoid working out altogether because you just don't have the time? Then
what I'm about to tell you should be music to your ears: when it comes to
exercise, less is more.
It's becoming increasingly clea... 阅读全帖 |
|
j****y
发帖数: 1714 | 46 【 以下文字转载自 Complain 讨论区 】
发信人: joyjoy (joy), 信区: Complain
标 题: 【投诉】running 版版主Rodimus威胁网友，无故删帖
发信站: BBS 未名空间站 (Sun Oct 6 02:20:59 2013, 美东)
我在running 版转帖了题为Extreme Endurance Exercise and heart attack的文章。
全篇文章都是认同跑步的好处，但是提醒过渡锻炼可能和心脏病有关联。
一些网友跳出来羞辱讽刺。我无所谓。文章总有喜欢和不喜欢的。
Rodimus对该帖极为不满，说running版不欢迎这类文章,封了很难看。同时说置顶文章
有类似讨论了。
我发帖反驳，问他是不是私人俱乐部，不允许公开发帖，同时要他拿出白底黑字的版规
看我违反了哪一条。我说我读了置顶文章，要么是空连接，要么内容不相同。
Rodimus 根本拿不出任何版规，居然发帖说我是受虐狂。
我发帖反驳说他动不动冒充全版不欢迎新人，还无根据威胁封人，是虐待狂。
Rodimus恼羞成怒，把我的帖子和后面更贴的对话全删了。
我要问站务，一个版... 阅读全帖 |
|
m******j
发帖数: 5079 | 47 今天看到的：
Study Finds New Evidence that Autism Begins During Pregnancy
Researchers at the University of California, San Diego School of Medicine
and the Allen Institute for Brain Science have published a study that gives
clear and direct new evidence that autism begins during pregnancy.
The study will be published in the March 27 online edition of the New
England Journal of Medicine.
The researchers – Eric Courchesne, PhD, professor of neurosciences and
director of the Autism Center of Excellence a... 阅读全帖 |
|
l******n
发帖数: 9344 | 48 厉害。其实这题和现在很多公司做的biomarker发面的研究很类似，我觉得如果这里结
果很好，说不定在biomarker预测疾病上很有借鉴作用 |
|
l******n
发帖数: 9344 | 49 厉害。其实这题和现在很多公司做的biomarker发面的研究很类似，我觉得如果这里结
果很好，说不定在biomarker预测疾病上很有借鉴作用 |
|
h*****o
发帖数: 342 | 50 我是外行，只是有兴趣
biomarker已经有很多种吧，比如从功能上分，有做diagnosis，有做prognosis
从性质上，有内源性的（某些酶啊），有体外合成的蛋白，有合成的化合物
从用法上，有口服的，有静脉注射的
从检测上，有用imaging (PET, MRI, ultrasound)，有生化方面的检测
如此粗略看看，取决于你的模型和治疗方法，biomarker是有很多不同的影响和局限，
可以扯很多了。
怎么validate，我想可能就是从体外->细胞/生化->动物模型->人
大家可以讨论一下。如果楼主可以提供更具体一点的信息就更方便深入一点讨论了 |
|
