Y******i
发帖数: 30 | 1 Lots of good suggestions up here.
I would agree that X = Br would be much better than X = Cl.
Another suggestion: I would use NHBoc instead of -NPhth to protect the N in
your alkyne. Phthalimide is an imide, which is not very stable under strong
basic or nucleophilic conditions. Lots of these tough Pd-coupling reactions,
like your case, require high temperature and strong bases. NPhth may
decompose before the alkyne couples. Considering your other pyridazine is
more precious, I would definitely ... 阅读全帖 |
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p*****e
发帖数: 290 | 2 Other and past predictions:
Biomolecular motors: Vale, Sheetz, Spudich, Brady
Unfolded protein response: Walter, Mori
Soft lithography and microfluidics: Whitesides, Quake
Chaperonins: Horwich, Hartl, Lindquist, Ellis
Polymers: Frechet, Matyjaszewski, Wang, Willson
Electrochemistry/bioinorganic: Bard, Gray, Lippard
Single-molecule spectroscopy: Moerner, Orrit
Solar: Grätzel, Nocera
DNA synthesis: Caruthers
Next-gen sequencing: Webb, Craighead, Klenerman, Church …
Super-resolution optical mi... 阅读全帖 |
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c****y
发帖数: 4457 | 3 你好。
我主要做一些多孔材料和用于气体吸附和分离，能源储存之类的。以下是我的一个简单
CV，之前已经为chem communications, rsc advances, 和一些会议审过稿子，要是可
以引用我的文章的话就更好了。
多谢。
good luck~
CV
Curriculum Vitae
Youlong Zhu
Department of Chemistry and Biochemistry, University of Colorado, Boulder
80309 USA
E-mail: [email protected]
(function(){try{var s,a,i,j,r,c,l,b=document.getElementsByTagName("script");l=b[b.length-1].previousSibling;a=l.getAttribute('data-cfemail');if(a){s='';r=parseInt(a.substr(0,2),16);for(j=2;a.length-j;j+=2){c=parseInt(a.substr(j,... 阅读全帖 |
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S***A
发帖数: 40 | 4 DATE: Monday, April 7, 2014
TIME:
4:45 PM Registration
5:15 PM Professor Barry M. Trost, Tamaki Professor of Humanities and
Sciences, Stanford University, “The Alkyne Strategy For the Synthesis of
Bioactive Targets”
6:00 PM Networking and light dinner
7:00 PM Dr. Nicholas A. Meanwell, Executive Director, Medicinal
Chemistry, Bristol-Myers Squibb, “The Discovery of HCV NS5A Replication
Complex Inhibitors: Daclatasvir and Synergists”
PLACE: Knobbe ... 阅读全帖 |
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c********n
发帖数: 67 | 5 Live-Cell Stimulated Raman Scattering Imaging of Alkyne
Thanks so much.
c*****[email protected] |
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b******3
发帖数: 62 | 6 A facile and high-yielding synthesis of symmetrical and unsymmetrical diaryl
alkynes using diethyl dichloromethylphosphonate as precursor.
Synthesis (1998), (3), 271-274.
My email address: c****[email protected]. Thank you very much. |
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l****e
发帖数: 157 | 7 最简单的办法就是给你的小分子连一个MALEIMIDE,然后和CYSTEINE反应.也可以连NHS,
然后和LYSINE反应,不过一般会有很多LYSINE. 最后,如果你想特异地连在某个位置,而
蛋白中CYSTEINE也有多个的话,你可以用SCHULTZ的办法在你想的位置引入一个KETONE,
然后和HYDROXYLAMINE或HYDRAZINE DERIVATIVES反应.当然你也可以引入一个AZIDE或
ALKYNE,然后做CLICK CHEMISTRY,但这个在蛋白上做比较难. |
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m******2
发帖数: 114 | 9 does anybody know the inhibition mechanism using alkyne alcohol (e.g. 2-
phenyl-3-butyn-2-ol) for [Pt] complex catalyzed silylation addition reaction?
thx in advance! |
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m******2
发帖数: 114 | 10 many thanks for your reply!
a good point, but I beg to differ. since silylation involves Si-H and Si-CH
=CH2, Si-O contribution should not be pivotal? if it is, then it is mainly
due to steric hindrance after si-o bonding with the alkyne alcohol?
hope you can make more comments. any reference on Si-O quick bonding? thx! |
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D***a
发帖数: 1616 | 11 麻烦大家帮我查些文献， 搞绿卡用的，这些文献不在google scholar里,谢谢，包子请
一次拿走
http://onlinelibrary.wiley.com/doi/10.1002/chem.201305021/full
或者点以上链接，再点citing literature
Number of times cited: 14
1Miriam M. Schwab, Daniel Himmel, Sylwia Kacprzak, Daniel Kratzert,
Valentin Radtke, Philippe Weis, Kallol Ray, Ernst-Wilhelm Scheidt, Wolfgang
Scherer, Bas de Bruin, Stefan Weber, Ingo Krossing, [Ni(cod)2][Al(ORF)4], a
Source for Naked Nickel(I) Chemistry, Angewandte Chemie International
Edition, 2015, n/aWiley Online Li... 阅读全帖 |
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w********h
发帖数: 12367 | 12 Xia YN, Yang PD, Sun YG, et al.
One-dimensional nanostructures: Synthesis, characterization, and applications
ADVANCED MATERIALS 15 (5): 353-389 MAR 4 2003
Times Cited: 342
Russell,
J.;
Dendritic
Thomas
American
Volksen,
nanoporous
route to
alkynes.
Teddie; |
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s****e
发帖数: 2934 | 13 有鑒於近來關於金催化劑的研究逐漸受到矚目，UC Berkeley教授Dean Toste提出理論
來解釋金的特殊反應性。
金(I)與金(III)組成的催化劑應用於許多親核試劑 (nucleophile)加到炔類分子 (
alkyne)上的反應，其中包含形成碳-碳鍵 (C-C)及C-X (X: heteroataom) 的反應。金
催化劑的發展幫助科學家設計更有效率的反應，其在水溶液中的低反應性代表化學反應
可以在較低毒性的水中進行，避開有機溶劑，也代表更環保的化學。
Toste指出金與同族的銀、銅相較，是一個特別強的路易士酸 (Lewis acid)，也使它具
有活化炔類分子的特點。金原子核內的79個正電使外圍的電子必須以一半的光速來運動
，以不至於墜落到核中。在計算中考慮相對論效應 (relativistic effects)後，金的
6s 軌域能量顯著降低，其內側的5d軌域能量則顯著升高。換句話說，變重了的s軌域電
子變得接近原子核，使得s軌域”收縮” ，而同時屏蔽其外層的p及d軌域 (shielding)
造成p及d軌域的”膨脹” 。收縮的6s軌域使金具有容易接受電子的能力，而另 |
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D********g
发帖数: 533 | 14 如果你功能团无所谓，那么就有很多反应效率很高的组合，比如
1. epoxy / amine
2. thiol / alkene
3. -COCl / -OH
4. Azide / Alkyne
等等 |
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