l**i
发帖数: 416 | 1 Chiral 3-aminopropanols. II. N-alkylated products
By Knabe, Joachim and Buchheit, Wolfgang
From Archiv der Pharmazie (Weinheim, Germany), 318(8), 727-35; 1985
Thanks,
l******[email protected] |
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g*****x
发帖数: 3283 | 3 1) DDT是还原disulfide的，IAM是alkylation还原的－S的，风马牛不相及。
2) 这么大的问题等于没问 |
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j***j
发帖数: 560 | 4 KAMETANI, TETSUJI (1985). "Synthesis of 4-alkyl-2(5H)-furanones.". Chemical
& pharmaceutical bulletin (0009-2363), 33 (1), p. 61.
Thanks in advance,
[email protected]/* */ |
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j***j
发帖数: 560 | 5 Amarjit S B,
New Developments in sulfuric acid alkylation.
Petroleum Technology Quarterly, 2007 (2):57
Thanks in advance!
[email protected]/* */ |
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i*n
发帖数: 9793 | 6 An Efficient Palladium-Catalyzed N-Alkylation of Amines Using Primary and
Secondary Alcohols
Tuan Thanh Dang, Balamurugan Ramalingam, Siah Pei Shan, and Abdul Majeed
Seayad*
Organic Chemistry, Institute of Chemical and Engineering Sciences, 8
Biomedical Grove, #07-01 Neuros, Singapore 138665.
ACS Catal., 2013, 3 (11), pp 2536–2540
DOI: 10.1021/cs400799n
Publication Date (Web): October 10, 2013 |
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n*********0
发帖数: 1543 | 8 癌细胞可不是每天都在产生。一个肿瘤发生是多次突变积累的过程。癌细胞从最初的突
变到发展成肿瘤是一个几十年的过程。有多道障碍要突破。完成了这些过程，才能成为
威胁生命的恶性肿瘤。
完成了这个过程的成熟癌细胞，有一个都是对生命的威胁。因为他是immortal的，可以
无限生长，只要有条件。
另外化疗有多种药物，alkylating agent, antimetabolites, antitubulin,
topoisomerase inhibitors etc.作用机理都大不相同。不是简单的氧化能概括的。
发展成恶性肿瘤，人体的immune surveillance已经早被突破，不是简单的“重建平衡
”就能控制癌细胞生长的。
要讨论癌症，就要明白他是个什么monster,为什么他是绝症。
氧化过程，而大多数中药对细胞的影响基本上是一个还原过程。这样会抵消化疗药物的
作用。这也是完全站在化疗药物的角度来考虑问题的。 |
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s*******d
发帖数: 56 | 9 我有一个朋友在国内做化工园区重点污染源在线监控体系研究。他想知道美国目前是否
对化工企业或园区的污染源进行了在线监控？是否选取了特征污染物？
我是个外行，有人知道吗？或者到哪里去找到答案那？ 非常感谢。
该系统包括特征污染物的在线监测、风险源监控点信息采集、信息监控点本地储存、信
息初步可靠性分析、信息无线和/或有线传输、信息远程监控中心储存，对获得的重点
环境风险源监控点的数据进行储存和实时处理，对风险源监控点的风险程度进行预警，
并将风险源的位置、监控点的位置等信息提供给监控部门，利用GIS空间分析技术分析
风险源周边的环境状况和居民、学校等敏感受体的分布，为监督管理部门制定应急预案
、指挥应急提供技术支持。
特征污染物的翻译：苯系物（苯benzene、甲苯toluene、二甲苯dimethylbenzene）、
取代苯（硝基苯nitrobenzene、氯苯chlorobenzene、苯胺aniline）、氯酚
chlorophenol、卤代烃halogenated hydrocarbon、烷烃alkyl hydrocarbon、多环芳烃
PolycyclicAromaticHyd |
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y****u
发帖数: 50 | 10 In ATRP, the concentraion of free radicals is kept very low
so as to minimize chain transfer and termination.
Most polymer chains are dormant with a halogen atom as endgroup.
A typical ATRP system consists of a monomer, initiator (usually alkyl halide),
catalyst (transition-Metal complexes), and ligand.
The added amide might react with other component instead of the free radical.
Quenching is used in living anionic polymerization to
prepare end-functionalized polymers,
but in ATRP, the halogen c |
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a*****c
发帖数: 3525 | 11 IR，left：3100－3000 cm-1 C-H (aromatic); 1600-1400 cm-1 C=C (aromatic)
right:3200-3600 cm-1 O-H; 2960-2850 cm-1, C-H (alkyl)
UV-vis, left: observable about 200-400 nm region;
right: almost none
1NMR, left: solvent: CDCl3/CD2Cl2/etc. ~7-8ppm, protons of phenyl ring,
~2-4ppm, of protons of the main chain.
right: solvent: D2O/CD3COCD3/(CD3)2SO/etc. proton of OH, and protons of
the main chain are different.
MS, fragments are different
elemental analysis, C, H.
and more if necessary. |
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S*****n
发帖数: 6055 | 12 【 以下文字转载自 Chemistry 讨论区 】
发信人: Synthon (Synthon@smth##bless smth), 信区: Chemistry
标 题: 求文献，多谢！
发信站: BBS 未名空间站 (Wed Jul 6 16:48:09 2005), 转信
Title: Inorganic-organic layered materials derived via the hydrolysis and polyco
ndensation of trialkoxy(alkyl)silanes
Author(s): Shimojima A, Sugahara Y, Kuroda K
Source: BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 70 (11): 2847-2853 NOV 1997
知道日本文献不好找，可是我正在读的三篇文献都引了这同一篇，觉得还是很有必要找来看
看的，呵呵。
请发到x*******[email protected]
多谢！ |
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m*****e
发帖数: 1506 | 13 【 以下文字转载自 Chemistry 讨论区 】
发信人: matrice (matrice), 信区: Chemistry
标 题: paper help, Thanks very much!
发信站: BBS 未名空间站 (Tue Jan 25 16:20:50 2011, 美东)
Synthesis of N-alkyl- and N-arylalkylacrylamides and micellar
copolymerization with acrylamide
European Polymer Journal
Volume 36, Issue 9, 1 September 2000, Pages 1853-1863
Thanks very much! |
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l******p
发帖数: 71 | 14 NBME 1 Block 2 question 25
A clone of cancer cells is resistant to vincristine, doxorubicin, and
dactinomycin but not to methotrexate and various alkylating agents. The
mechanism of resistance is most likely to involve
a) absence of superoxide dismutase
b) altered DNA polymerase
c) enhanced drug transport out of cell
d) inability to form polyglutamates
e) increased DNase
NBME 1 Block 2 question 42
A 49 yrs old man has a 1week history of shortness of breath ,with no fever ,
chills or cough.Breath... 阅读全帖 |
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S*****n
发帖数: 6055 | 15 长链alkyl amine制备mesoporous silica是P先生先做的？
为啥我读到的paper都是sarayi和janareic的。。。 |
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r***n
发帖数: 15 | 16 想用一端是SH另一端是NH2的ligand来合成AuNP，S连在Au上，NH2暴露在外面做后面的
反应。合成方法选用在EtOH里用NaBH4还原HAuCl4。但是alkyl amine本身也可以用来稳
定AuNP，虽然说SH应该是比NH2更强的配体，但是还是担心NH2的存在会不会对AuNP的合
成造成影响。
另外，SH和NH2是处于酸碱平衡中，大部分的存在形式是S(-)和NH3(+)。不知道这个会
不会影响S和Au第一步反应的前驱物的形成。
有人做过类似的合成吗？多谢指点。实在是这个ligand有点贵，100mg要300刀，不太敢
乱试。要尽量多的将NH2连上去，所以暂时不考虑exchange的办法。 |
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y*********8
发帖数: 37 | 17 We are a biotech startup to develop next generation of chemotherapeutic
agent such as novel antimetabolite, Pt-based compounds, DNA alkylating
agents. We are looking for a scientific adviser who has extensive knowledge
of traditional chemotherapy, both in preclinical and clinical study.
Requirement:
1. Strong interest in small business, especially biotech start.
2. PhD or MD from top US school in cancer biology, oncology, or related
field .
3. Strong research interest in cancer translational re |
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K******S
发帖数: 10109 | 18 It's hard to give you suggestions without knowing the exact sequence of
those peptides. (K/R position, size, hydrophobicity etc assuming you use c18 column)
Did you do reduction/alkylation before digestion?
What's your trypsin/protein ratio? |
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l*******k
发帖数: 63 | 19 DTT是还原剂，IAM是alkylation agent，两者作用完全不同啊。 |
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s**********8
发帖数: 25265 | 20 Sterilization (microbiology)
http://en.wikipedia.org/wiki/Sterilization_(microbiology)
From Wikipedia, the free encyclopediaJump to: navigation, search This
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