M***e
发帖数: 531 | 1 不知道大家对afatinib这个药有没有了解。现在家人肺癌1a期，担心复发，有clinical
trial用afatinib来预防复发。。有点担心副作用，会不会很大？好像现在afatnib只
是用于治疗，预防效果未知。不知道吃这个药的利弊会是怎样。。 |
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s**n
发帖数: 25 | 2 【 以下文字转载自 Medicine 讨论区 】
发信人: sein (sein), 信区: Medicine
标 题: 请问如何买到bibw 2992 （Afatinib)
发信站: BBS 未名空间站 (Sun May 27 11:19:07 2012, 美东)
国内一个朋友的亲戚患了肺癌，合并脑癌。听说靶向药物bibw 2992 （Afatinib)可能
有用。不知道如何才能搞到？
多谢 |
|
s**n
发帖数: 25 | 3 【 以下文字转载自 Medicine 讨论区 】
发信人: sein (sein), 信区: Medicine
标 题: 请问如何买到bibw 2992 （Afatinib)
发信站: BBS 未名空间站 (Sun May 27 11:19:07 2012, 美东)
国内一个朋友的亲戚患了肺癌，合并脑癌。听说靶向药物bibw 2992 （Afatinib)可能
有用。不知道如何才能搞到？
多谢 |
|
s**n
发帖数: 25 | 4 【 以下文字转载自 Medicine 讨论区 】
发信人: sein (sein), 信区: Medicine
标 题: 请问如何买到bibw 2992 （Afatinib)
发信站: BBS 未名空间站 (Sun May 27 11:19:07 2012, 美东)
国内一个朋友的亲戚患了肺癌，合并脑癌。听说靶向药物bibw 2992 （Afatinib)可能
有用。不知道如何才能搞到？
多谢 |
|
s**n
发帖数: 25 | 5 国内一个朋友的亲戚患了肺癌，合并脑癌。听说靶向药物bibw 2992 （Afatinib)可能
有用。不知道如何才能搞到？
多谢 |
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f****o
发帖数: 2770 | 6 afatinib是针对metastatic non small cell lung cancer
stage 1a吃这个干什么。。。 |
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I****a
发帖数: 407 | 7 what you do now: start taxol plus avastin.
与此同时取活检查T790M mutation,为将来用Afatinib alone or Afatinib plus
cetuximab 做准备. Afatinib is not even readily available for us patients so
it might take a great while for Chniese patients.
前面的回答都挺好但不实际. |
|
I****a
发帖数: 407 | 8 what you do now: start taxol plus avastin.
与此同时取活检查T790M mutation,为将来用Afatinib alone or Afatinib plus
cetuximab 做准备. Afatinib is not even readily available for us patients so
it might take a great while for Chniese patients.
前面的回答都挺好但不实际. |
|
yf
发帖数: 272 | 9 Afatinib 对T790M mutation 没有效果。不要浪费钱了。要用afatinib+Cetuximab. 或
者参加临床试验，astrazanaca 有一个专门对付T790M的新药，clinicaltrial ongoing
. Data 还没出来，但是估计很好。几天以后ASCO会有preilim data |
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t*******n
发帖数: 4445 | 10
能有用。不知道如何才能搞到？
* Does the patient's doctor recommend it and is willing to supervise its use
? If not, forget the whole thing.
* If yes, it has been imported into china as 阿法替尼. Buying cancer drugs
in the US without a doctor's prescription is illegal, and no doctor will
prescribe it without seeing the patient. |
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I****a
发帖数: 407 | 11 I would suggest to continue Tarceva and Zometa and if your father has only
localized bone metastasis. If the new scan shows more progressive findings,
I would suggest to add Alimta in addition. Alimta is a fairly benign
chemotherapy and the side effects are minimal. If that fails I would then
consider Avastin combination. At any time, he could try Afatinib (an
more potent form of Tarceva) if it is available. This drug likely will be
approved in US by the end of this year.
I am against what so ca... 阅读全帖 |
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i*****y
发帖数: 19 | 12 Thanks for the suggestions! I looked at Afatinib clinical trials. A few
ongoing trails do include Chinese sites, although the recruitment has not
started yet. Will need to read their eligibility criteria more carefully and
follow up. Thanks!
, |
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I****a
发帖数: 407 | 13 Some of the unique points of this particular lung cancer are:
1. It is EGFR mutation positive now likely has gained the resistance
mechanism.
2. The majority of the metastasis are in brain (not surprising) and bones.
So following cookie cutting algorithm may not be the optimal way to go.
There is nothing wrong to give him platinum doublet although I favor Alimta
in the doublet given the result from PARAMOUNT data and it is probably more
reasonable in my opinion to start with 1 agent given his pr... 阅读全帖 |
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s****t
发帖数: 101 | 14 afatinib 上市了，可以在中国找到行医的美国医生开处方，上海就有这样的医生，你
拿处方到美国肿瘤药房取药 |
|
n****r
发帖数: 5801 | 15 为什么不实际呢？afatinib还没上市么？
so |
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l*h
发帖数: 4124 | 16 there are a few points here:
1. afatinib has only been tested in a few hundred patients. its actual
efficacy, IN REALITY, is not known.
2. regarding T790M mutation, the claim "50%的抗药是因为癌细胞变异成t790m" is
very wrong. it is a misinterpretention of results of some articles, mainly
William Pao's highly cited report. the actual results are in ~50% of tumors
resistant to gefinitib or erlotinib, T790M was detected. this doesn't mean
the resistance is necessarily caused by this mutation. only some T790M-
p... 阅读全帖 |
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C*****e
发帖数: 2102 | 17 我婶婶没有做基因检测就直接上afatinib了。她说是因为那个很辛苦。希望你谅解。
如果这个也产生抗药下面做什么呢？我们希望能先准备起来。
is
mainly
tumors |
|
l*h
发帖数: 4124 | 18 good to hear.
one big thing of EGFR inhibitors is the high rate of ILD-like response in
Chinese/Japanese/Koreans patients, which has a high fatality rate. afatinib
showed roughly the same rate of ILD-like response in east Asian patients as
that of erlotinib/gefitinib. so if she develops new breathing problems, don'
t spontaneously assume it's the cancer getting worse. a simple plain chest X
-ray can detect ILD-like response if read carefully. |
|
|
s****t
发帖数: 101 | 20 afatinib 上市了，可以在中国找到行医的美国医生开处方，上海就有这样的医生，你
拿处方到美国肿瘤药房取药 |
|
n****r
发帖数: 5801 | 21 为什么不实际呢？afatinib还没上市么？
so |
|
l*h
发帖数: 4124 | 22 there are a few points here:
1. afatinib has only been tested in a few hundred patients. its actual
efficacy, IN REALITY, is not known.
2. regarding T790M mutation, the claim "50%的抗药是因为癌细胞变异成t790m" is
very wrong. it is a misinterpretention of results of some articles, mainly
William Pao's highly cited report. the actual results are in ~50% of tumors
resistant to gefinitib or erlotinib, T790M was detected. this doesn't mean
the resistance is necessarily caused by this mutation. only some T790M-
p... 阅读全帖 |
|
C*****e
发帖数: 2102 | 23 我婶婶没有做基因检测就直接上afatinib了。她说是因为那个很辛苦。希望你谅解。
如果这个也产生抗药下面做什么呢？我们希望能先准备起来。
is
mainly
tumors |
|
l*h
发帖数: 4124 | 24 good to hear.
one big thing of EGFR inhibitors is the high rate of ILD-like response in
Chinese/Japanese/Koreans patients, which has a high fatality rate. afatinib
showed roughly the same rate of ILD-like response in east Asian patients as
that of erlotinib/gefitinib. so if she develops new breathing problems, don'
t spontaneously assume it's the cancer getting worse. a simple plain chest X
-ray can detect ILD-like response if read carefully. |
|
|
C*****e
发帖数: 2102 | 26 再上来更新，婶婶吃了afatinib前三个月疗效不明显，也辛苦，她一再要求停药。那时
是春节。本来以为过不了节，但是婶婶又坚持过来了。各项指标也有好转。还回了一趟
海南老家看看亲人。特此上来谢谢大家的意见鼓励。生命不是必然，点滴都需珍惜。 |
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D*****6
发帖数: 4 | 27 第一次在这里发言，搞了几天才弄好，争取发在13年。
我也是肺癌4期患者，是NSCLC EGFR Exon19。这些是基因变异的标识。有这三项指标，
大多数医生闭着眼睛都会开Tarceva。我开始很好，3个月癌细胞明显减少，6-8个月后
就从Pet/CT scan 上消失了。但医生打死也不说那是remission。果然2周前去测癌细胞
又回了了，Tarceva的有效期平均是9-12个月，我的运气还算好，坚持了12个月的正常
生活（正常上班，没有因看病请过一天假，一般的检查在1-2小时完成）。所以这个圣
诞假期主要任务是研究下一步用什么药。我的医生建议化疗为首选，Tarceva一定要停
（失效了）。从病友那里了解到去年FDA批了一个药Afatinib，主要对EGFR Exon19/21
有效，据说比Tarceva还要强大。我已建议我医生去了解对我的适用性，希望对我有效。
总的说我对和癌抗争下去是挺有信心的。
一起加油 |
|
M***e
发帖数: 531 | 28 Afatinib已经批了么？好像还是在phase iii的clinical trial
21
效。 |
|
D*****6
发帖数: 4 | 29 第一次在这里发言，搞了几天才弄好，争取发在13年。
我也是肺癌4期患者，是NSCLC EGFR Exon19。这些是基因变异的标识。有这三项指标，
大多数医生闭着眼睛都会开Tarceva。我开始很好，3个月癌细胞明显减少，6-8个月后
就从Pet/CT scan 上消失了。但医生打死也不说那是remission。果然2周前去测癌细胞
又回了了，Tarceva的有效期平均是9-12个月，我的运气还算好，坚持了12个月的正常
生活（正常上班，没有因看病请过一天假，一般的检查在1-2小时完成）。所以这个圣
诞假期主要任务是研究下一步用什么药。我的医生建议化疗为首选，Tarceva一定要停
（失效了）。从病友那里了解到去年FDA批了一个药Afatinib，主要对EGFR Exon19/21
有效，据说比Tarceva还要强大。我已建议我医生去了解对我的适用性，希望对我有效。
总的说我对和癌抗争下去是挺有信心的。
一起加油 |
|
M***e
发帖数: 531 | 30 Afatinib已经批了么？好像还是在phase iii的clinical trial
21
效。 |
|
u**o
发帖数: 4652 | 31 据我LP说国内网络上的理论是癌细胞不减少（无变化）就像耐药了？因为之前爷爷也没
感觉咳嗽，也没住院，所以怀疑已经耐药。
现在知道台湾有卖Afatinib 2992， 是不是下一步该吃这个？ |
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f****o
发帖数: 2770 | 32 Afatinib would be a reasonable choice |
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M***e
发帖数: 531 | 33 是医院的clinical trial..想看看这个药对于早期1a患者有没有起到防止复发的作用。
就是用它来扫荡身体里的癌细胞残余。。
话说，腺癌1a复发率有多少呢？听说有20-30%。这么高么？ |
|
|
|
l****1
发帖数: 168 | 36 能有办法买到么？美国，加拿大，印度？国内亲戚拿来延长生命用，很想帮忙。请大家
给点建议。也可以给我站内留言。谢谢了！！ |
|
s*********a
发帖数: 148 | 37 你去www.51qiji.com上面问问，我印象中有国内病友买到了，他们有自己的渠道。你最
好找病友，那些专门卖药的药贩子不仅卖的贵，还有卖假药的。 |
|
|
r******y
发帖数: 62 | 39 请转求医问药版： 胆管癌靶向药咨询
我有一个朋友的父亲（在中国国内）患胆管癌晚期。主治医生说有一种靶向药叫阿法替
尼（Afatinib, 商品名 Gilotrif) 是美国生产的。他有几个问题想请教一下大家：
1。 这个药的效果怎样？
2。价格在美国大体是多少？
3。 国内的人能从美国买到吗？怎麽买？
非常感谢！ |
|
h****s
发帖数: 16779 | 40 1.请咨询病人的医生
2.每月大约8000刀
3.买不到
[在 readonly (antivirus) 的大作中提到：]
:请转求医问药版： 胆管癌靶向药咨询
:我有一个朋友的父亲（在中国国内）患胆管癌晚期。主治医生说有一种靶向药叫阿法
替尼（Afatinib, 商品名 Gilotrif) 是美国生产的。他有几个问题想请教一下大家：
:1。 这个药的效果怎样？
:非常感谢！ |
|
i*********g
发帖数: 1940 | 41 阿法替尼Afatinib试过没有?去年FDA批准的，声称是突破性的治疗方法，我看副作用很小 |
|
f****n
发帖数: 114 | 42 paper 1
Title: Irreversible EGFR Inhibitors in the Treatment of Advanced NSCLC
Journal: Curr Pharm Des
paper 2
Title: Afatinib for the treatment of patients with EGFR-positive non-small
cell lung cancer.
Journal: Drugs Today (Barc). 2013 Sep;49(9):523-35.
my email is f********[email protected]
Thanks! will send boazi. |
|
M**1
发帖数: 327 | 43 erlotinib 用的比较多，有些病人用了好几年了。afatinib也可以 |
|
d***a
发帖数: 77 | 44 【 以下文字转载自 Medicalpractice 讨论区 】
发信人: derma (小小小菜鸟), 信区: Medicalpractice
标 题: 国内的处方能在这边买药么？
发信站: BBS 未名空间站 (Wed Sep 23 18:27:00 2015, 美东)
一个亲戚得了肺癌。国内的医生建议服用Gilotrif（Afatinib）。但是这药国内没有，
所以家人问我能不能在北美给买到。
我想请教各位：
1）用国内的处方这里可以买到么？药房或者网上？
2）如果国内的处方这边不承认，一般的家庭医生不见到病人可以给开药么？
3）还有其它什么办法可以买到这种药？还是说根本不可能买到？
我自己平时很少看医生。我的家庭医生最近在休假。所以想请教大家。
先谢过！ |
|
I****a
发帖数: 407 | 45 I doubt any of the Iressa clinical trial would be applicable to your mom
given what you were saying she is still responding which could last longer I
hope. But eventually most of the tumor will develop resistance mechanisms,
examples like c-met over expression and EGFR kinase domain mutation T790M.
There are active clinical trials to deal with those situations, drug like
ARQ197, a c-met inhibitir; Afatinib, an irreversible EGFR tyrosine kinase
inhibitor. Your mom could participate those trials i... 阅读全帖 |
|
I****a
发帖数: 407 | 46 I doubt any of the Iressa clinical trial would be applicable to your mom
given what you were saying she is still responding which could last longer I
hope. But eventually most of the tumor will develop resistance mechanisms,
examples like c-met over expression and EGFR kinase domain mutation T790M.
There are active clinical trials to deal with those situations, drug like
ARQ197, a c-met inhibitir; Afatinib, an irreversible EGFR tyrosine kinase
inhibitor. Your mom could participate those trials i... 阅读全帖 |
|
I****a
发帖数: 407 | 47 It might be useful for paients with EGFR mutation but lose the response to
conventional EGFR tyrosine kinase inhibitor due to T790M mutation.
It is still in clinical trial so it is not available unless your relative is
enrolled to one for appropriate indication. |
|
I****a
发帖数: 407 | 48 It might be useful for paients with EGFR mutation but lose the response to
conventional EGFR tyrosine kinase inhibitor due to T790M mutation.
It is still in clinical trial so it is not available unless your relative is
enrolled to one for appropriate indication. |
|
|
c*******4
发帖数: 52 | 50 是指新上市的Gilotrif (afatinib)么？
如果没法在美国买到的话，可以试试在中国买它的原材料BIBW2992，国内很多肺癌患者
都这么用来着。 |
|
