b*****l
发帖数: 9499 | 1 【 以下文字转载自 Biology 讨论区 】
发信人: isola (小石头), 信区: Biology
标 题: Re: Math/Systems/Synthetic Biology 人物榜
发信站: BBS 未名空间站 (Thu Apr 29 10:55:35 2010, 美东)
补几个个人观点（难得搞定tor）
1. Oudenaarden在我心目中是个天才级人物。最近同一时期发表一篇cell和一篇
sicence。
其中science文章是从现象角度证明并量化一种假说 circadian gating的假说。其实就
是设计测量两种rhythm的相关性，并用物理量和模型（非常简单的模型，物理强调的是
简化问题，抓住问题核心）刻画这一相关性， Circadian gating of the cell cycle
revealed in single cyanobacterial cells
cellpaper给出这个假说背后的生物机制
http://www.hubmed.org/display.cgi?uids=20178745
2. 现在大家都往data上结合实验开展工作了。 |
P*********y
发帖数: 310 | 2 Has read Oudenaarden's early work on gene expression noise, really admiring
him.
I guess I just admire people who came from a physics background, who have
solid math training and systems-level view of dynamical systems.
cycle
【在 b*****l 的大作中提到】
: 【 以下文字转载自 Biology 讨论区 】
: 发信人: isola (小石头), 信区: Biology
: 标 题: Re: Math/Systems/Synthetic Biology 人物榜
: 发信站: BBS 未名空间站 (Thu Apr 29 10:55:35 2010, 美东)
: 补几个个人观点（难得搞定tor）
: 1. Oudenaarden在我心目中是个天才级人物。最近同一时期发表一篇cell和一篇
: sicence。
: 其中science文章是从现象角度证明并量化一种假说 circadian gating的假说。其实就
: 是设计测量两种rhythm的相关性，并用物理量和模型（非常简单的模型，物理强调的是
: 简化问题，抓住问题核心）刻画这一相关性， Circadian gating of the cell cycle
|
w***a
发帖数: 226 | 3 guess intrinsic and extrinsic noises are ideas from statistcial physics.
Also wanna mention Prof. Terry Hwa, who is the editor of physical biology.
His group has paper published in Cell recently and many many PNAS. |
l**********n
发帖数: 201 | 4 For the concept of "noise", the problem for us molecular biologists, it's
hard to judge it without experimental support. How can we test your
hypothesis? What's the molecular basis? For I myself, it's difficult to
accept the "black box" idea when we really do science. Maybe I haven't yet
入门。:)
【在 w***a 的大作中提到】
: guess intrinsic and extrinsic noises are ideas from statistcial physics.
: Also wanna mention Prof. Terry Hwa, who is the editor of physical biology.
: His group has paper published in Cell recently and many many PNAS.
|
P*********y
发帖数: 310 | 5 Noise is more of an engineering term borrowed to describe fluctuation in
protein expression levels.
The molecular basis is crystal clear: due to the stochastic (random) nature
of chemical reactions (collision between molecules, required for reaction to
occur, is random event, which becomes pronounced when number of molecules
in the systems are low).
So even if a protein expression level settles to a long-term steady state,
there will be moment-to-moment fluctuations in the copy number of the
pro
【在 l**********n 的大作中提到】
: For the concept of "noise", the problem for us molecular biologists, it's
: hard to judge it without experimental support. How can we test your
: hypothesis? What's the molecular basis? For I myself, it's difficult to
: accept the "black box" idea when we really do science. Maybe I haven't yet
: 入门。:)
|
l**********n
发帖数: 201 | 6 Very informative! Thanks!
nature
to
car
【在 P*********y 的大作中提到】
: Noise is more of an engineering term borrowed to describe fluctuation in
: protein expression levels.
: The molecular basis is crystal clear: due to the stochastic (random) nature
: of chemical reactions (collision between molecules, required for reaction to
: occur, is random event, which becomes pronounced when number of molecules
: in the systems are low).
: So even if a protein expression level settles to a long-term steady state,
: there will be moment-to-moment fluctuations in the copy number of the
: pro
|
p*******r
发帖数: 4048 | 7 what does terry work on?
biology.
【在 w***a 的大作中提到】
: guess intrinsic and extrinsic noises are ideas from statistcial physics.
: Also wanna mention Prof. Terry Hwa, who is the editor of physical biology.
: His group has paper published in Cell recently and many many PNAS.
|
w***a
发帖数: 226 | 8 sorry for the late reply. Terry's group
works on a bunch of quantitatitve bio topics:
gene regulation, cell growth, metabolism, using E. coli as the model system,
evolutionary biology, etc.
【在 p*******r 的大作中提到】
: what does terry work on?
:
: biology.
|
