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发帖数: 139 | 1 It is unclear whether severe acute respiratory syndrome coronavirus 2, which
causes coronavirus disease 2019, can enter the brain. Severe acute
respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its
spike protein. We show that intravenously injected radioiodinated S1 (I-S1)
readily crossed the blood–brain barrier in male mice, was taken up by brain
regions and entered the parenchymal brain space. I-S1 was also taken up by
the lung, spleen, kidney and liver. Intranasally administered I-S1 also
entered the brain, although at levels roughly ten times lower than after
intravenous administration. APOE genotype and sex did not affect whole-brain
I-S1 uptake but had variable effects on uptake by the olfactory bulb, liver
, spleen and kidney. I-S1 uptake in the hippocampus and olfactory bulb was
reduced by lipopolysaccharide-induced inflammation. Mechanistic studies
indicated that I-S1 crosses the blood–brain barrier by adsorptive
transcytosis and that murine angiotensin-converting enzyme 2 is involved in
brain and lung uptake, but not in kidney, liver or spleen uptake. | i********r
发帖数: 139 | 2 估计武汉病毒也可以。
对S1蛋白的毒性现在还没有很好的研究。 | i********r
发帖数: 139 | 3 It is unclear whether severe acute respiratory syndrome coronavirus 2, which
causes coronavirus disease 2019, can enter the brain. Severe acute
respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its
spike protein. We show that intravenously injected radioiodinated S1 (I-S1)
readily crossed the blood–brain barrier in male mice, was taken up by brain
regions and entered the parenchymal brain space. I-S1 was also taken up by
the lung, spleen, kidney and liver. Intranasally administered I-S1 also
entered the brain, although at levels roughly ten times lower than after
intravenous administration. APOE genotype and sex did not affect whole-brain
I-S1 uptake but had variable effects on uptake by the olfactory bulb, liver
, spleen and kidney. I-S1 uptake in the hippocampus and olfactory bulb was
reduced by lipopolysaccharide-induced inflammation. Mechanistic studies
indicated that I-S1 crosses the blood–brain barrier by adsorptive
transcytosis and that murine angiotensin-converting enzyme 2 is involved in
brain and lung uptake, but not in kidney, liver or spleen uptake. | i********r
发帖数: 139 | 4 估计武汉病毒也可以。
对S1蛋白的毒性现在还没有很好的研究。 |
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