w******8
发帖数: 59 | 1 If some patient drop out immediately after randomization in a RCT, what do
we do to keep the two group size equal?
Thanks! | d***2
发帖数: 341 | 2 for phase 1 studies, replacements is often done for drop-outs. When a
subject drops out, the next enrolled subject gets the same randomization
numbers...etc...as long as it's well defined in protocol.
in phase II+ trials, an additional portion of subjects is added into the
study based on estimated drop-out rate (such as 15-20%) to maintain the
power. Imbalanced drop-out is another story, you will have to look into the
discontinuation mechanism by using pattern mixture...etc.
【在 w******8 的大作中提到】
: If some patient drop out immediately after randomization in a RCT, what do
: we do to keep the two group size equal?
: Thanks!
| x*****r
发帖数: 2404 | 3 Why do you have to keep the group size 'perfectly' equal?
【在 w******8 的大作中提到】
: If some patient drop out immediately after randomization in a RCT, what do
: we do to keep the two group size equal?
: Thanks!
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