我有6个TREATMENT ARM (n=8 for each arm)
1 is control to eatablish the disease model: vehicle(t=0)+ A(t=0)
2-7 is treated at different TIME POINTS:
2:pre-Treatment(at t= 0) + A (at t= 0)
3:pre_Treatment (at t= -2h)+ A (at t= 0)
4:pre_Treatment(at t= -4h) + A (at t= 0)
5:pre-Treatment(at t= -8h) + A (at t= 0)
6:pre-Treatment (at t= -12h)+ A (at t= 0)
7:pre-Treatment(at t= -24h) + A (at t= 0)
The problem is like for treatment arm 3-7, there is no strict paired control
as the vehicle was also pretreate
