t***5
发帖数: 832 | 1 【 以下文字转载自 Military 讨论区 】
发信人: take5 (∞), 信区: Military
标 题: 奥利奇善胶囊有用吗？
发信站: BBS 未名空间站 (Thu Jan 10 12:49:37 2013, 美东)
最近国内很多人在买一个叫奥利奇善壳寡糖胶囊的，
请问有用吗？是否又是一个忽悠老人的骗人东西？
美国有相关的产品吗? | y*****s
发帖数: 1047 | 2 是这个？好像是说曾认为有减肥的作用
http://en.wikipedia.org/wiki/Chitosan
Preliminary research and FDA review
Supposed to limit fat absorption in the body, chitosan may be sold in tablet
form as a "fat binder". In one preliminary study, a 1% decrease in body
mass index was seen with supplementation of chitosan over 8 weeks.[39]
However, in a Cochrane meta-analysis,[40] which evaluated clinical trials
performed with dietary chitosan over a minimum of four weeks, body weight,
blood pressure and parameters related to cholesterol were changed only in
some low-quality trials, indicating a minor effect on body weight. Other
higher quality trials indicated no significant effect of chitosan and no
clinical justification for advising overweight patients to take chitosan
supplements.[40]
In an experimental model of the digestive tract, chitosan was shown to
interact with oil, which inhibited duodenal absorption and enhanced lipid
excretion.[41] However, the mechanism of interaction between chitosan and
fat is not well understood and has not been proved clinically.[42] In mice,
dietary ingestion of chitosan did not depress the level of iron, zinc or
copper.[43]
The FDA has issued warning letters to supplement retailers who made
inappropriate claims about the supposed health benefits of using chitosan.[
44]
Chitosan is currently under research for several potential clinical
applications:[45]
As a soluble dietary fiber, it increases gastrointestinal lumen viscosity
and slows down the emptying of the stomach.
It alters bile acid composition, increasing the excretion of sterols and
reducing the digestibility of ileal fats.[46][47][48] It is unclear how
chitosan does this, but the currently favored hypotheses involve the
increase of intestinal viscosity or bile acid-binding capacity.[49]
Chitosan is relatively insoluble in water, but can be dissolved by dilute
acids, which would make it a highly-viscous dietary fiber.[49] Such fibers
might inhibit the uptake of dietary lipids by increasing the thickness of
the boundary layer of the intestinal lumen, which has been observed in
animal experiments.[50]
Having very few acetyl groups, chitosan contains cationic groups. This may
cause chitosan to have bile acid-binding capacity, which causes mixed
micelles to be entrapped or disintegrated in the duodenum and ileum.[49]
This would interrupt bile acid circulation, causing reduced lipid absorption
and increased sterol excretion, which has also been observed in animal
experiments.[48][49][50] |
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