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发帖数: 4124 | 1 ☆─────────────────────────────────────☆
CaMKII (不作postdog) 于 (Sat Nov 8 01:18:35 2008) 提到:
发信人: CaMKII (不作postdog), 信区: Biology
标 题: 北大邓宏魁发了一篇Cell Stem Cell
发信站: BBS 未名空间站 (Fri Nov 7 22:09:29 2008)
做的也是iPSC，看来和国外跟得很紧啊。
北大今年ms很牛，除了程和平之前发的一篇Cell，程还有一篇Nature被接受，另外尚永
丰也有一篇Cell被接受。
Cell Stem Cell, Volume 3, Issue 5, 475-479, 6 November 2008
doi:10.1016/j.stem.2008.10.002
Two Supporting Factors Greatly Improve the Efficiency of Human iPSC
Generation
Yang Zhao1, 4, Xiaolei Yin1, 2, 4, Han Qin1, 2, 4, Fangfang Zhu1, 2, 5,
Haisong Liu1, 2, 5, Weifeng Yang1, 5, Qiang Zhang1, 2, 5, Chengang Xiang1, 2
, 5, Pingping Hou1, 5, Zhihua Song1, 2, Yanxia Liu1, 2, Jun Yong1, Pengbo
Zhang1, Jun Cai1, Meng Liu1, 2, Honggang Li1, Yanqin Li1, Xiuxia Qu1, Kai
Cui1, Weiqi Zhang1, Tingting Xiang1, Yetao Wu1, 2, Yiding Zhao1, Chun Liu1,
2, Chen Yu1, Kehu Yuan2, Jinning Lou3, Mingxiao Ding1 and Hongkui Deng1, 2,
,
1 Department of Cell Biology and Genetics, College of Life Sciences, Peking
University, Beijing 100871, China
2 Laboratory of Chemical Genomics, Shenzhen Graduate School of Peking
University, The University Town, Shenzhen 518055, China
3 Institute of Clinical Medical Sciences, China-Japan Friendship Hospital,
Beijing 100029, China
Corresponding author
4 These authors contributed equally to this work
5 These authors contributed equally to this work
Summary
Human fibroblasts can be induced into pluripotent stem cells (iPSCs), but
the reprogramming efficiency is quite low. Here, we screened a panel of
candidate factors in the presence of OCT4, SOX2, KLF4, and c-MYC in an
effort to improve the reprogramming efficiency from human adult fibroblasts.
We found that p53 siRNA and UTF1 enhanced the efficiency of iPSC generation
up to 100-fold, even when the oncogene c-MYC was removed from the
combinations.
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ghoul (泡泡龙) 于 (Sat Nov 8 02:04:01 2008) 提到:
这是啥杂志
没听说过
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Lumanman (biology) 于 (Sat Nov 8 13:47:54 2008) 提到:
这是Cell杂志社刚出的新杂志，估计影响因子将来出来的时候会在15左右。是干细胞方
面除了Cell， Nature，Science最好的杂志。应该类似于Neuron杂志在神经领域的地位。 |
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