c***e
发帖数: 1207 | 1 南非的研究说辉瑞疫苗接种者的血清， 其对抗omicron的效力比对抗原始株平均下降了
40倍。
Omicron likely to weaken COVID vaccine protection
https://www.nature.com/articles/d41586-021-03672-3
A study led by virologist Alex Sigal, at the African Health Research
Institute in Durban, South Africa, found that serum – the antibody-
containing portion of blood — from 12 people who received the Pfizer-
BioNtech vaccine was 40 times less potent against Omicron, on average,
compared to an earlier strain of SARS-CoV-2. That was similar to two other
studies: one reported by Pfizer and BioNtech in an 8 December press release,
and the other released on Twitter by virologist Sandra Ciesek at Goethe
University in Frankfurt, Germany. | S*******l
发帖数: 4637 | 2 根据这个中和抗体水平下降模型推算疫苗保护效力：
Summary
Omicron's 30-40-fold reduction in neut. antibody titers will lead to
ESTIMATED:
~10-14% reduction in VE HOSPITALIZATION
~40-60% reduction in SYMPTOMATIC INFECTION
Both of these can be mostly mitigated by 3rd dose booster.
只打两针mRNA,有症状感染保护可能下降40-60%，住院保护率下降10-14%.
打booster，抗体有更长的成熟期，免疫保护会更robust，保护力下降不显著。
今天辉瑞针对omicron的数据也出来了，booster以后，保护力依然可靠。
诸位将军，打疫苗，打booster，别拿自己和家人生命去做无谓的赌博 | u*******e
发帖数: 1 | 3 Missense mutations 太多
抗体亲和力大幅度下降
release,
【在 c***e 的大作中提到】
: 南非的研究说辉瑞疫苗接种者的血清， 其对抗omicron的效力比对抗原始株平均下降了
: 40倍。
: Omicron likely to weaken COVID vaccine protection
: https://www.nature.com/articles/d41586-021-03672-3
: A study led by virologist Alex Sigal, at the African Health Research
: Institute in Durban, South Africa, found that serum – the antibody-
: containing portion of blood — from 12 people who received the Pfizer-
: BioNtech vaccine was 40 times less potent against Omicron, on average,
: compared to an earlier strain of SARS-CoV-2. That was similar to two other
: studies: one reported by Pfizer and BioNtech in an 8 December press release,
| c***e
发帖数: 1207 | 4 不是我不信疫苗， 三月的时候我天天看什么时候能轮到我， 一来message就马上打了。
可到现在， 对辉瑞自己报的数， 开始半信半疑了。 期望看到有更多的独立的研究
【在 S*******l 的大作中提到】
: 根据这个中和抗体水平下降模型推算疫苗保护效力：
: Summary
: Omicron's 30-40-fold reduction in neut. antibody titers will lead to
: ESTIMATED:
: ~10-14% reduction in VE HOSPITALIZATION
: ~40-60% reduction in SYMPTOMATIC INFECTION
: Both of these can be mostly mitigated by 3rd dose booster.
: 只打两针mRNA,有症状感染保护可能下降40-60%，住院保护率下降10-14%.
: 打booster，抗体有更长的成熟期，免疫保护会更robust，保护力下降不显著。
: 今天辉瑞针对omicron的数据也出来了，booster以后，保护力依然可靠。
| w***a
发帖数: 432 | 5
了。
Dude, I don't know what you mean by saying this, totally lost. If you don't
know, or don't understand, what they say about all the details, then just
believe them on the last words: go get the boost.
【在 c***e 的大作中提到】
: 不是我不信疫苗， 三月的时候我天天看什么时候能轮到我， 一来message就马上打了。
: 可到现在， 对辉瑞自己报的数， 开始半信半疑了。 期望看到有更多的独立的研究
| D********r
发帖数: 135 | 6 很好奇，这个“中和抗体水平下降模型”是什么文章里面的？
【在 S*******l 的大作中提到】
: 根据这个中和抗体水平下降模型推算疫苗保护效力：
: Summary
: Omicron's 30-40-fold reduction in neut. antibody titers will lead to
: ESTIMATED:
: ~10-14% reduction in VE HOSPITALIZATION
: ~40-60% reduction in SYMPTOMATIC INFECTION
: Both of these can be mostly mitigated by 3rd dose booster.
: 只打两针mRNA,有症状感染保护可能下降40-60%，住院保护率下降10-14%.
: 打booster，抗体有更长的成熟期，免疫保护会更robust，保护力下降不显著。
: 今天辉瑞针对omicron的数据也出来了，booster以后，保护力依然可靠。
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