A*********f
发帖数: 452 | |
t*******e
发帖数: 723 | |
V*******n
发帖数: 1 | |
t*******e
发帖数: 723 | 4 知乎说重症无效并不能否定这个药
傻逼难道不会一有症状就吃，起码保证不死啊
吃药的没有死亡的 |
t*******e
发帖数: 723 | |
t*******e
发帖数: 723 | 6 如果这药不行，早晚会暴露
人民希望被干死了，马药也干死了，不可能只有这个假药能挺住 |
s*****y
发帖数: 145 | |
r*****g
发帖数: 9999 | 8 这也太牛逼了，副作用比安慰剂还小是如何做到的
: 反正没有副作用，副作用比安慰剂对照组还小
【在 t*******e 的大作中提到】
: 如果这药不行，早晚会暴露
: 人民希望被干死了，马药也干死了，不可能只有这个假药能挺住
|
l**a
发帖数: 11 | 9 可以通过中枢神经系统产生欣快感
类似鸦片的药用价值
【在 r*****g 的大作中提到】
: 这也太牛逼了，副作用比安慰剂还小是如何做到的
:
:
: 反正没有副作用，副作用比安慰剂对照组还小
:
|
s*****y
发帖数: 145 | 10 any negative effects, even those unlikely to be caused by the medication,
need to be reported as adverse effects. It allows for making a clean
comparison between the placebo, and also makes it possible to retroactively
relate effects that have been overlooked previously. For example, you want '
patient was hit by a car' as possible side effect, because the medication
could make people drowsy.
【在 r*****g 的大作中提到】
: 这也太牛逼了，副作用比安慰剂还小是如何做到的
:
:
: 反正没有副作用，副作用比安慰剂对照组还小
:
|
s*****y
发帖数: 145 | 11 Please read the excellent popular science book "Cure: A Journey into the
Science of Mind Over Body" by author/journalist Jo Marchant. It gives an
excellent overview of all things placebo related.
【在 l**a 的大作中提到】
: 可以通过中枢神经系统产生欣快感
: 类似鸦片的药用价值
|
s*****y
发帖数: 145 | 12 关于是否致癌
this study doesn't show that molnupiravir (rNHC) is genotoxic at levels
effective for treating covid. Dosage of 1µm reduced COVID+ cells by 15x
, while 3µm removed the infection entirely. [2] 1µm and even 3&#
181;m dosing didn't lead to any statistically significant genotoxicity, only
10µm showed effects [3].
The authors know this, because their conclusion is that the risk of
genotoxicity "might not be zero." They have not demonstrated that
therapeutic doses cause any statistically significant increase in mutations.
1. https://academic.oup.com/jid/article/224/3/415/6272009?login...
2. https://academic.oup.com/view-large/figure/283696469/jiab247...
3. https://oup.silverchair-cdn.com/oup/backfile/Content_public/... |
c*********n
发帖数: 1282 | |
s*****y
发帖数: 145 | 14 是否导致胎儿致畸
Molnupiravir, being a polymerase inhibitor (in layman's terms it "jams up
replication machinery"), has the potential for mutagenicity. In fact it was
dropped by a Gilead subsidiary for this exact reason. [1]
> A company called Pharmasset Inc. (a hepatitis C drugmaker Gilead bought in
2011) investigated molnupiravir’s main ingredient around the turn of the
century, but it abandoned development over concerns that it was mutagenic,
meaning it could lead to birth defects.
Actually the article is slightly wrong, mutagenic is causing mutations in
the host's germ or somatic DNA, teratogenic is causing birth defects. Most
mutagens are teratogens too. From the Dr Bright complaint filing, Bright was
concerned about reproductive toxicity (teratogenicity) so I'm not sure if
the article meant to say teratogenic, or the concern is that the drug is
both mutagenic and teratogenic (polymerase drugs tend to be both).
Subsequent tests seem to have shown a lack of mutagenic activity in hosts (
eg Painter 2021), at least enough to get through safety trials, which is
excellent. But looking at it from a structural activity point of view,
molnupiravir is way, way more likely to have a DNA-affecting mechanism than
mRNA. It has also shown mutagenic effect in vitro [2]. Nonetheless, a small
increase in cancer risk years down the road (especially in the over-70 crowd
) is likely worth the 50% (!) reduction in mortality.
It's probably fine, as long as you aren't pregnant. Like all drugs, it's
about risk/benefit ratio. The covid vaccine has a much more favorable
profile and should still be the preferred option. I doubt it'll be approved
for pregnant women without a reproductive toxicity study.
1 - https://www.bloomberg.com/news/features/2021-03-25/merck-mrk...
2 - https://pesquisa.bvsalud.org/global-literature-on-novel-coro...
Search for 'β-D-N4-hydroxycytidine safety' if you wanna dig deep. |
l*******2
发帖数: 1 | 15 比这两个劲儿大
【在 c*********n 的大作中提到】
: 比的上 连花清瘟 和 润肺排毒汤 吗？
|
s*****y
发帖数: 145 | 16 Atea Pharmaceutical is finishing up phase 3 trial of a Covid anti-viral pill
in November that might be more effective (based on phase 2 trial data) and
doesn't mutate the virus: https://ateapharma.com/at-527/ |
t*******e
发帖数: 723 | 17 马药是灵丹妙药，支持耗子和五毛多吃，其他人还是算了 |
s*****y
发帖数: 145 | |
t*******e
发帖数: 723 | |
