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发帖数: 194 | 1 现在高度怀疑因为抗原原罪，delta疫苗没法出来，所以政府推武汉病毒booster第三针
https://www.tandfonline.com/doi/full/10.1080/21645515.2021.1949953
Most current COVID-19 vaccines are designed to incorporate the dominant
viral antigen of the SARS-CoV-2, i.e., the S-protein. If the updated
vaccines against the new mutations were based on the same type of antigen
protein (S-protein only), the effect of original antigenic sin could be
strengthened as mentioned above in the case of vaccination with the
nonavalent HPV vaccine. We can only speculate that if the vaccine contained
more antigenic components (such as the common influenza vaccine with
hemagglutinin and neuraminidase), the chances of overcoming original
antigenic sin would have been increased. Therefore, it is obvious to
consider multicomponent vaccines which, in addition to the S-protein, could
also contain nucleocapsid or envelope proteins of SARS-CoV-2.
As suggested by a recent observation in naturally immunized individuals
receiving two doses of the Pfizer COVID-19 (Comirnaty) vaccine, original
antigenic sin may pose a problem in future research and development of
vaccines.16 While the first dose of the vaccine was able to raise the
preexisting levels of functional and specific antibodies, these either
failed to change or even declined after the second dose (virus-neutralizing
antibodies), and the same applied to the levels of antigen-specific antibody
-secreting cells. As this observation was made in only a small group of 13
subjects with naturally acquired immunity against SARS-CoV-2, who had rather
average or below-average levels of the antibodies assessed, one may expect
an enhanced effect of original antigenic sin after new vaccination against
COVID-19 in those with manyfold higher antibody levels after complete
immunization. | o***o
发帖数: 194 | 2 Hence, the extremely high levels of specific anti-SARS-CoV-2 antibodies
achieved by vaccination, which – as indicated by the most recent data –
tend to persist for months post-vaccination, should serve as a warning sign.
14,15 In addition,
作者认为疫苗导致的高浓度抗体，是抗原原罪的警告信号 | o***o
发帖数: 194 | 3 抗原原罪，灭活估计好很多
mRNA又赢了，高抗体浓度 -》抗原原罪 |
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