c******n
发帖数: 5697 | 1 First, in a small study involving 30 patients, hydroxychloroquine, used on
top of conventional treatments, cleared the virus in 13 (86.7%) cases on day
7, while 14 (93.3%) patients in the control group had the virus cleared,
according to a study abstract Raffat obtained. One patient on the malaria
med progressed to severe during the treatment.
The median duration from hospitalization to virus-negative testing, as well
as the median time to body temperature normalization, were also similar
between the two arms. The only positive signal was disease progression shown
on CT scans, which five hydroxychloroquine cases showed, versus seven in
the control group. But Raffat said the trial size was simply too small to
draw conclusions
https://www.fiercepharma.com/pharma-asia/top-covid-19-aspirants-chloroquine-
abbvie-s-kaletra-and-a-flu-drug-disappoint-clinical |
n*****5
发帖数: 1 | |
R****y
发帖数: 1 | |
c******n
发帖数: 5697 | |
E*******F
发帖数: 2165 | |
a******g
发帖数: 13519 | 6 不管有没有效，反正现在是没货了。
硬度跟中国都出台了限制令，一颗奎宁都不许过太平洋，吼吼吼！！！ |
J**e
发帖数: 1 | 7 你这个试验每天才给四百毫克羟氯喹，这个小屁剂量够干嘛的呀，还不如喝五
瓶Tonic Water。
day
well
shown
【在 c******n 的大作中提到】
: First, in a small study involving 30 patients, hydroxychloroquine, used on
: top of conventional treatments, cleared the virus in 13 (86.7%) cases on day
: 7, while 14 (93.3%) patients in the control group had the virus cleared,
: according to a study abstract Raffat obtained. One patient on the malaria
: med progressed to severe during the treatment.
: The median duration from hospitalization to virus-negative testing, as well
: as the median time to body temperature normalization, were also similar
: between the two arms. The only positive signal was disease progression shown
: on CT scans, which five hydroxychloroquine cases showed, versus seven in
: the control group. But Raffat said the trial size was simply too small to
|
c******n
发帖数: 5697 | 8 呵呵一样的东西，羟氯喹有效药量比磷酸氯喹小，副作用小得多
【在 E*******F 的大作中提到】
: 你说这个是羟氯喹，不是磷酸氯喹啊
|
E*******F
发帖数: 2165 | 9 这里是各种总结
On 13 February 2020, hydroxychloroquine and chloroquine were recommended by
a South Korean task force for the experimental treatment of coronavirus
disease 2019 (COVID-19).[32] In vitro studies in cell cultures demonstrated
that hydroxychloroquine was more potent than chloroquine against SARS-CoV-2.
[33][34]
On 17 March 2020, the AIFA Scientific Technical Commission of the Italian
Medicines Agency expressed a favorable opinion on including the off-label
use of chloroquine and hydroxychloroquine for the treatment of COVID-19.[35]
A randomized controlled trial by Chinese researchers showed no positive
effect with hydroxychloroquine at a dosage of 400 mg per day.[36] A study
from Marseille, France, showed a reduction in viral load at a dosage of 600
mg a day, however, the study was criticized for its methodology.[37] The
people were not randomized and three from the treatment group that was
transferred to an intensive care unit and one who died were excluded from
the analysis.[38] |
c******n
发帖数: 5697 | 10 这是治疟疾标准疗法
loading dose 400 mg q12h, 然后qd
【在 J**e 的大作中提到】
: 你这个试验每天才给四百毫克羟氯喹，这个小屁剂量够干嘛的呀，还不如喝五
: 瓶Tonic Water。
:
: day
: well
: shown
|
|
|
s********r
发帖数: 312 | 11 这是patient selection criteria的问题，clinical trial design 101。不是什么病
人可以拿来随便比的，选一大堆轻症，对照组93%的病人都能康复，那还吃个屁药啊。 |
N**********i
发帖数: 161 | 12 现在不是在治疟疾
lol
【在 c******n 的大作中提到】
: 这是治疟疾标准疗法
: loading dose 400 mg q12h, 然后qd
|
w********9
发帖数: 8613 | 13 这是硫酸羥氯喹
不是磷酸氯喹
诊疗方案里提的是磷酸氯喹，比硫酸羥氯喹的水可溶性和吸收性高很多
有法国人和美国人用在病人身上说是有效 |
L**********g
发帖数: 498 | |
s*********2
发帖数: 1572 | 15 川普在推特上又打脸自己了？
【在 n*****5 的大作中提到】
: 土鳖的治疗手册又闹笑话了
|
c******n
发帖数: 5697 | 16 你不是废话么？raondomized control trial 30个人有个屁用，end point都没有定义
power也没有
你这样说90%的文章不用发了
【在 s********r 的大作中提到】
: 这是patient selection criteria的问题，clinical trial design 101。不是什么病
: 人可以拿来随便比的，选一大堆轻症，对照组93%的病人都能康复，那还吃个屁药啊。
|
c******n
发帖数: 5697 | 17 你土了，美国医生都用这个计量
【在 N**********i 的大作中提到】
: 现在不是在治疟疾
: lol
|
N**********i
发帖数: 161 | 18 30个人的trial, 也就能发发和厕所纸一样的文章了
屁实际用处也没有
lol
【在 c******n 的大作中提到】
: 你不是废话么？raondomized control trial 30个人有个屁用，end point都没有定义
: power也没有
: 你这样说90%的文章不用发了
|
N**********i
发帖数: 161 | 19 美国医生在治疗新官上是最落后的了吧
lol
【在 c******n 的大作中提到】
: 你土了，美国医生都用这个计量
|
a***s
发帖数: 1084 | 20 看看论文作者的说法，丫实验做的就不对，药量就没达到有效剂量 |
R****y
发帖数: 1 | 21 要命的是这些文章有误导性。就跟中国的新冠数据一样。
: 30个人的trial, 也就能发发和厕所纸一样的文章了
: 屁实际用处也没有
: lol
【在 N**********i 的大作中提到】
: 美国医生在治疗新官上是最落后的了吧
: lol
|
c******n
发帖数: 5697 | 22 呵呵中国蒙古大夫们对loading dose都不知道怎么用 |
