l*******6
发帖数: 34 | 1 FA2010 page 232 states beta-2 receptor increases insulin release. But FA2009
page 226 says beta-2 receptor increases glucagon release. Which one is
correct?
It seems 2010 FA is correct. But UW has an explanation about the target
organ of beta-2 adrenergic blockade is glucagon secretion. Kind of confused.
Please kindly clarify. Thank you. |
L********a
发帖数: 576 | 2 这个问题你要搞清楚它是通过什么通路来起作用的。
beta-2受体是通过Gs通路起作用，激活Gs,升高cAMP.
Glucagon也是通过cAMP起作用的，也是升高cAMP.
Insulin是降低cAMP.
这样你可以看出来，beta-2是升高血糖，这没有问题。
Insulin抑制Glucogan.但是Glucogan刺激Insulin.
但是你说的最后一个我也不知道。 |
c******s
发帖数: 5583 | 3 read 2010, it says there very clearly.
The glugacon is antidote for B blocker overdose (increase cAMP again like
Largepizza explained). |
l*******6
发帖数: 34 | 4 Thanks Pizza for the "Glucogan刺激Insulin". Therefore, both FA2010 (beta-2 receptor increases insulin release) and FA2009 (beta-2 receptor increases
glucagon release) should be correct. |
l*******6
发帖数: 34 | 5 Thank you cancidas.
【在 c******s 的大作中提到】
: read 2010, it says there very clearly.
: The glugacon is antidote for B blocker overdose (increase cAMP again like
: Largepizza explained).
|
s**********r
发帖数: 178 | 6 查了一下药理书，和2010版是一致的，估计2009版的是错的。 我的理解如下：
beta2 agonist和glucagon都是升高cAMP,都有升血糖的作用。 血糖过高，自然会刺激
insulin的分泌，从而来降血糖。
反过来，阻断beta2会导致血糖低，血糖过低的时候，又刺激glucagon分泌,从而来升血
糖。
所以这两条其实是一个硬币的两个面？
FA2009
confused.
【在 l*******6 的大作中提到】
: FA2010 page 232 states beta-2 receptor increases insulin release. But FA2009
: page 226 says beta-2 receptor increases glucagon release. Which one is
: correct?
: It seems 2010 FA is correct. But UW has an explanation about the target
: organ of beta-2 adrenergic blockade is glucagon secretion. Kind of confused.
: Please kindly clarify. Thank you.
|
