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发帖数: 195 | 1 adjudicative review
TITLE: Restore the osteogenic activity of bacterial debris contaminated
titanium by doping of magnesium
Journal：Journal of Materials Chemistry B
ABSTRACT:
Immobilizing Ag NPs can give titanium contact-killing actions against the
colonization of bacteria. However, this antimicrobial manner may produce
bacterial debris, which likely compromises the osteogenic property of the
material. Magnesium, as an effective stimulus for boosting the osteogenic
performances in bone cells, may neutralize the adverse impact. Accordingly,
the present study illuminates the effect of bacterial debris (BD) and
lipopolysaccharide (LPS, a kind of endotoxins in microbial debris) on the
osteogensis of titanium, which was surface-modified by magnesium (Mg) and/or
silver (Ag) plasmas. It was found that the unfavorable effects of LPS and
BD on osteoblastic differentiation of human bone marrow mesenchymal stem
cells (hBMSCs) can be dismissed by doping of magnesium on the titanium
surface. And titanium co-doped of magnesium and silver, even under the
challenge of bacteria, sees the best osteointegration in vivo. This study
highlight bacterial debris can impair the osseointegration of implants and
co-doping of magnesium and silver is a promising method to solve this issue.
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