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a*********0
发帖数: 213 | 1 Very small paper, no impact factor
journal biochemistry insight
Title Extracellular Matrix and Integrins in Embryonic Stem Cell
Differentiation
Abstract : Embryonic stem cells (ESC) are pluripotent cells with great
therapeutic potentials. The in vitro differentiation of ESC was designed by
recapitulating embryogenesis. Significant progress has been made to improve
the in vitro differentiation protocols by toning soluble maintenance factors
. However, more robust methods for lineage specific differentiation and
maturation are still under development. Considering the complexity of in
vivo embryogenesis environment, extracellular matrix (ECM) cues should be
considered besides growth factor cues. ECM proteins bind to cells and act as
ligands of integrin receptors on cell surfaces. Here, we summarize the role
of the ECM and integrins in the formation of three germ layer progenies.
Various ECM-integrin interactions were found facilitating differentiation
towards definitive endoderm, hepatocyte-like cells, pancreatic beta cells,
early mesodermal progenitors, cardiomyocytes, oligodendrocytes, neural and
glial lineages, and neural crest stem cells. In the future, ECM combinations
for the optimal ESC differentiation environment will require substantial
study.
想要的给我站内消息，给我一个你简单的background。 | a*********0
发帖数: 213 | |
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