T**7
发帖数: 264 | 1 牙科学的顶尖杂志，影响因子是3-4之间。
这个杂志并且包含生物技术，生化，微生物，免疫学等基础学科的稿件。
稿件题目：
Mesenchymal stem cells as active pro-healing and immunosuppressive agents in
periapical environment: evidences from human and experimental periapical
lesions
摘要：
Abstract:
Introduction: Previous studies describe contrasting molecular profiles of
active and inactive periapical granulomas characterized by distinct
expression of cytokines, osteoclastogenic factors and wound healing markers.
Although the molecular mechanisms underlying such dichotomy remain unknown,
in this present study we investigated the potential involvement of
mesenchymal stem cells (MSCs) in determining human and murine periapical
lesions activity and outcome.
Methods: Periapical granulomas (N=83) and control samples (N=24) were
comparatively assessed for the expression levels of 11 MSCs markers through
RealTimePCR. Experimental periapical lesions induced in mice (pulp exposure
and bacterial inoculation) were evaluated for MSCs markers expression and
effects of AMD3100 treatment on lesions outcome.
Results: MCSs markers expression were prevalent in periapical granulomas
than in controls, being CD29, CD73, CD90, CD146, CD166, NANOG, Stro-1 and
CXCR4 expression higher in inactive than active lesions. Experimental
periapical lesions inactivity was also associated with increased expression
of MSCs markers; the inhibition of MSCs mobilization to periapex by AMD3100
resulted in increased lesions size, decreased expression of MSCs and wound
healing markers, and increased expression of IL-1b, IL-17, TNF-a, IFN-g and
RANKL.
Conclusion: Our results demonstrate that MSCs markers are overexpressed in
inactive human and experimental periapical lesions, and that MSCs
mobilization result in the attenuation of experimental lesions progression
associated with immunosuppressive and pro-healing mechanisms.
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【在 T**7 的大作中提到】
: 牙科学的顶尖杂志，影响因子是3-4之间。
: 这个杂志并且包含生物技术，生化，微生物，免疫学等基础学科的稿件。
: 稿件题目：
: Mesenchymal stem cells as active pro-healing and immunosuppressive agents in
: periapical environment: evidences from human and experimental periapical
: lesions
: 摘要：
: Abstract:
: Introduction: Previous studies describe contrasting molecular profiles of
: active and inactive periapical granulomas characterized by distinct
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