w*****n 发帖数: 214 | 1 请教各位一个关于有机分析的问题,我有一个5员环的lactone,在pH10的水溶液(10%
ACN)中25C两小时后完全水解,产物在HPLC上可以看出来,而且在pH4时又迅速变回原来
的lactone。但在旋转蒸发仪上抽干时,产物也会变回原lactone。估计是水解成酸和醇
,但需要NMR和MS证明。
现在想用可以在碱性条件下的试剂把反应产物fix上,比如生成酯或硅醚之类。希望知
道的朋友不吝指导。 | F********y 发帖数: 7139 | | w*****n 发帖数: 214 | 3 Thanks for your reply first.
I have not tried in reagent methnol, but I believe even after the acid form
methyl ester with methnol, it still will be replaced with intra molecular
hydroxy group to form the lactone again during concentration. | a******w 发帖数: 898 | |
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