w*****n
发帖数: 42 | 1 Does anyone have experience on deprotecting of phthaloyl and
tetrachlorophthaloyl group. I used phthaloyl group to protect amino acid in
my synthesis. Now the deprotection is a problem. Because there is a acylal
gropu in the final product, when I tried to use hydrazine to remove the
phthaloyl group, the acylal was also broken. Some literature said that
tetrachlorophthaloyl group is much milder to be removed. I wonder anyone had
same problem or any experience on that.
Thank you in advance |
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