C*********X
发帖数: 10518 | 1 【 以下文字转载自 Faculty 讨论区 】
发信人: CornucopiaX (丁春秋), 信区: Faculty
标 题: Re: 北大95生物系女生，海归，潜水不幸遇难
发信站: BBS 未名空间站 (Sun Oct 1 12:25:50 2017, 美东)
这个第三作的文章，比较有意思。。 在正常人身上做的这个working memory 的测试，
很有意思。。。这402 healthy adults的取材比较讲究吧，。。她是遗传系的。。为什
么不找家族（pedigree)来做这个实验，这样结果会更丰富。。不是都说，精神病
scheziphina是遗传的吗？
欢迎，各位老师加入讨论啊。。。
Catechol-O-methyltransferase (COMT) genotypes and working memory:
associations with differing cognitive operations.
Bruder GE1, Keilp JG, Xu H, Shikhman M, Schori E, Gorman JM, Gilliam TC.
Author information
Abstract
BACKGROUND:
Catechol-O-methyltransferase (COMT) is a strong candidate gene for
schizophrenia and cognitive functions disrupted in this disorder. This
report examines the relation of COMT genotypes to performance on a battery
of working memory tests differing in the cognitive operations to be
performed on the material.
METHODS:
A large sample of 402 healthy adults were tested on four working memory
tests: Spatial Delayed Response (SDR), Word Serial Position Test (WSPT), N-
back, and Letter-Number Sequencing. A subsample (n = 246) was tested on the
Wisconsin Card Sorting Test (WCST). A saliva swab was used to obtain DNA
from all participants.
RESULTS:
Letter-Number Sequencing, which requires both storage and manipulation of
information, was the only working memory test that showed expected
differences among COMT genotypes, with the met/met group showing the best
performance and the val/val group the poorest performance. As in previous
studies, the met/met group also performed better than the val/val group on
the WCST.
CONCLUSIONS:
COMT genotypes were not associated with performance on tests measuring
simple storage, maintenance of temporal order or updating of information in
working memory. Genotype differences in Letter-Number Sequencing and WCST
suggest that higher-order components of processing (e.g., mental
manipulation) are more closely related to this gene. | c******o
发帖数: 1184 | 2 penetrance 可能太低，很难拿到有效的pedigree
【在 C*********X 的大作中提到】
: 【 以下文字转载自 Faculty 讨论区 】
: 发信人: CornucopiaX (丁春秋), 信区: Faculty
: 标 题: Re: 北大95生物系女生，海归，潜水不幸遇难
: 发信站: BBS 未名空间站 (Sun Oct 1 12:25:50 2017, 美东)
: 这个第三作的文章，比较有意思。。 在正常人身上做的这个working memory 的测试，
: 很有意思。。。这402 healthy adults的取材比较讲究吧，。。她是遗传系的。。为什
: 么不找家族（pedigree)来做这个实验，这样结果会更丰富。。不是都说，精神病
: scheziphina是遗传的吗？
: 欢迎，各位老师加入讨论啊。。。
: Catechol-O-methyltransferase (COMT) genotypes and working memory:
| C*********X
发帖数: 10518 | 3 *Penetrance in genetics is the proportion of individuals carrying a
particular variant (or allele) of a gene (the genotype) that also express an
associated trait (the phenotype).
**Which country has the highest rate of schizophrenia?
6 to 12 million people in China (a rough estimate based on the
population)
4.3 to 8.7 million people in India (a rough estimate based on the
population)
2.2 million people in USA.
285,000 people in Australia.
Over 280,000 people in Canada.
Over 250,000 diagnosed cases in Britain.
***Schizophrenia affects around 0.3–0.7% of people at some point in their
life
,[1] or 21 million people worldwide as of 2011 (about one of every 285).[2]
By using precise methods in its diagnosis and a large, representative
population, schizophrenia seems to occur with relative consistency over time
during the last half-century.[3]
While it is claimed that schizophrenia occurs at similar rates worldwide,
its prevalence and incidence varies across the world,[4] within countries,[5
] and at the local and neighborhood level.[6] It causes approximately 1% of
worldwide disability-adjusted life years (DALYs).[7] The rate of
schizophrenia varies up to threefold depending on how it is defined.[1]
从那个图上来看，亚洲地区居然是重灾区。。。
【在 c******o 的大作中提到】
: penetrance 可能太低，很难拿到有效的pedigree
| h*******o
发帖数: 4884 | 4 Schizophrenia, despite having a relatively strong genetic component in its
etiology, is not a hereditary disease. | C*********X
发帖数: 10518 | 5 I see.
Thanks
【在 h*******o 的大作中提到】
: Schizophrenia, despite having a relatively strong genetic component in its
: etiology, is not a hereditary disease.
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