L**o
发帖数: 15 | 1 wt和ko小鼠同时皮下MOG/CFA免疫，一周后取脾细胞用MOG刺激，发现ko组的上清里
IL17A和IFN均下降。
可是之后尝试KLH/CFA免疫后，这两种cytokine的表达水平相比于wt，都没有变化，对
于IFNg来说，甚至在KO里有所升高高。
请问这该如何解释?难道仅仅是抗原大小不同？
多谢！ | s*******n
发帖数: 37 | 2 1. MOG is a self antigen, and MOG-reactive T cells are subject to central
tolerance in the thymus.
2. MOG is just a peptide, and can be presented to T cells without going
through the MHCII presentation. KLH has to be processed first before being
loaded to class II. |
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