哪位评价下? http://www.ipscell.com/2014/09/what-do-sperm-have-to-do-with-br
What do sperm have to do with brain tumors?
Posted on September 21, 2014
H3.3 knockoutSometimes in science there are unexpected threads tying
seemingly very different things together.
Unraveling the knots in these threads can lead to new insights into
important developmental processes and mechanisms of disease.
My lab studies epigenomic and transcription factors including a molecule
called histone variant H3.3 (more here on H3.3).
H3.3 binds to the actual thread of DNA to create very different kinds of
chromatin states than those made by the more traditional canonical histone
H3 family members. Think of H3.3 as the unorthodox member of the histone H3
family.
Recent studies have indicated that H3.3 plays key roles in both stem cells
and cancer.
