h****y
发帖数: 77 | 1 It's about aging. Any comment?
Turns out that the elusive Fountain of Youth may exist after all … in our
heads.
Scientists at the Albert Einstein School of Medicine say they’ve discovered
a brain region that may control aging throughout the entire body. By
manipulating that region, they were able to extend the lives of mice by 20
percent. The finding, detailed in a paper published in Nature on May 1, may
lead to new ways of warding off age-related diseases and increasing life
spans.
The hypothalamus, an almond-size area of the brain, controls growth,
reproduction, and metabolism but also initiates aging, according to the
study. Dongsheng Cai, a physiologist at Albert Einstein College of Medicine
in New York, together with colleagues, realized this by tracking NF-κB, a
molecule that controls DNA transcription and is involved in inflammation and
the bodily response to stress. They found that in mice, NF-κB becomes more
active in the hypothalamus with age.
Mice that were injected with a substance that inhibits NF-κB’s activity
lived longer—up to 20 percent longer—while those injected with a substance
that stimulated the molecule died earlier.
What’s more, the inhibitor seems to block the lamentable physical decline
that occurs with age. Six months after the initial experiment, mice that had
been injected with inhibitors performed better than controls on cognition
and movement tests. “They also showed less age-related decline in muscle
strength, skin thickness, bone mass, and tail-tendon integrity,” according
to an article in Nature.
Blocking NF-κB had similar effects on male and female mice and produced
anti-aging effects even in middle-aged mice.
David Sinclair, a molecular biologist at Harvard Medical School in Boston,
called the study, “a major breakthrough in aging research.” He says it
will likely benefit research into age-related diseases such as Alzheimer’s
and arthritis. | C***2
发帖数: 62 | 2 I think that it is very interesting. I ever thought the similar questions
. Cai Lab is very strong on the inflammation/hypothalamus function/NF-kB/
Diabetes and ageing. Actually we don't know clearly if there are "trigger or
switch" in our body to control or execute system ageing.This paper
partially answer the question.
Also, many environmental factors influence ageing. Ageing is systemic "
phenotype", maybe, different tissues have different mechanisms to regulate
ageing.
discovered
may
【在 h****y 的大作中提到】
: It's about aging. Any comment?
: Turns out that the elusive Fountain of Youth may exist after all … in our
: heads.
: Scientists at the Albert Einstein School of Medicine say they’ve discovered
: a brain region that may control aging throughout the entire body. By
: manipulating that region, they were able to extend the lives of mice by 20
: percent. The finding, detailed in a paper published in Nature on May 1, may
: lead to new ways of warding off age-related diseases and increasing life
: spans.
: The hypothalamus, an almond-size area of the brain, controls growth,
|
|
