l****t
发帖数: 102 | 1 The 2011 Nobel Prize in Physiology or Medicine was divided, one half jointly
to Bruce A. Beutler and Jules A. Hoffmann "for their discoveries concerning
the activation of innate immunity" and the other half to Ralph M. Steinman
"for his discovery of the dendritic cell and its role in adaptive immunity". |
f********n
发帖数: 6465 | 2 不会又是假信息吧，反正我第二楼。
先天免疫系统包括一系列的细胞及相关机制，可以以非特异性的方式抵御外来感染。先天免疫系统的细胞会非特异地识别并作用于病原体。与获得性免疫系统不同，先天免疫系统不会提供持久的保护性免疫，[1]而是作为一种迅速的抗感染作用存在于所有的动物和植物之中
樹狀細胞是一種存在於哺乳動物的一種白血球。它存在於血液和暴露於環境中的組織中，如皮膚和鼻子、肺、胃和小腸的上皮組織。它們的作用是調節對當前環境刺激的先天和後天免疫反應。[1]它的其中一個最重要的功能就是將抗原處理後展示給免疫系統的其他白細胞，故是一種抗原提示細胞。樹狀細胞是一種哺乳類的免疫細胞。簡而言之，主要功能為施加抗原物質在免疫系統中其他的細胞上。 |
a****k
发帖数: 1130 | 3 上来感慨一下老头们又一次刚挖来人就得奖的壮举。。。
继续睡去。。。
jointly
concerning
Steinman
".
【在 l****t 的大作中提到】
: The 2011 Nobel Prize in Physiology or Medicine was divided, one half jointly
: to Bruce A. Beutler and Jules A. Hoffmann "for their discoveries concerning
: the activation of innate immunity" and the other half to Ralph M. Steinman
: "for his discovery of the dendritic cell and its role in adaptive immunity".
|
S*********s
发帖数: 304 | 4 师妹啊，要注意休息
【在 a****k 的大作中提到】
: 上来感慨一下老头们又一次刚挖来人就得奖的壮举。。。
: 继续睡去。。。
:
: jointly
: concerning
: Steinman
: ".
|
S*********s
发帖数: 304 | 5 师妹啊，要注意休息
【在 a****k 的大作中提到】
: 上来感慨一下老头们又一次刚挖来人就得奖的壮举。。。
: 继续睡去。。。
:
: jointly
: concerning
: Steinman
: ".
|
l*******r
发帖数: 39279 | 6 wow
原来Bruce Beutler这么牛的
jointly
concerning
Steinman
".
【在 l****t 的大作中提到】
: The 2011 Nobel Prize in Physiology or Medicine was divided, one half jointly
: to Bruce A. Beutler and Jules A. Hoffmann "for their discoveries concerning
: the activation of innate immunity" and the other half to Ralph M. Steinman
: "for his discovery of the dendritic cell and its role in adaptive immunity".
|
c******g
发帖数: 9273 | 7 wow
jointly
concerning
Steinman
".
【在 l****t 的大作中提到】
: The 2011 Nobel Prize in Physiology or Medicine was divided, one half jointly
: to Bruce A. Beutler and Jules A. Hoffmann "for their discoveries concerning
: the activation of innate immunity" and the other half to Ralph M. Steinman
: "for his discovery of the dendritic cell and its role in adaptive immunity".
|
d*******u
发帖数: 943 | |
c******n
发帖数: 492 | 9 it said that he shenghuo zuofei not good:( |
i***R
发帖数: 663 | 10 哈哈，校长早上发信，很沾沾自喜的说这个月才把Bruce Beutler又请回来，这就得诺
奖了。不过他的开创性工作应该还是在西南做的。 |
|
|
a****k
发帖数: 1130 | 11 师兄同学，你又换马甲了？？
我也不知道，平时睡的很死的，结果今天一大早就醒了手机查查情况。你说那帮每年排
队等着得奖的该多煎熬啊，一年一次的煎熬。。。没有希望就不会失望啊，哈哈
【在 S*********s 的大作中提到】
: 师妹啊，要注意休息
|
l*******r
发帖数: 39279 | 12 wiki上更新好快，貌似是个神童啊
23岁就MD了
老爸也是scripps的professor,看起来不管是哪个圈子父子兵都很常见
Education
Between 1959 and 1977, Beutler lived in Southern California. He received his
secondary school education at Polytechnic School in Pasadena, CA. He
attended college at the University of California, San Diego, graduating at
the age of 18 in 1976. He enrolled in medical school at the University of
Chicago in 1977 and received his M.D. degree in 1981 at the age of 23.
Academic positions
From 1981 to 1983 Beutler continued his medical training at the University
of Texas Southwestern Medical Center in Dallas, TX as an intern in the
Department of Internal Medicine, and as a resident in the Department of
Neurology. Between 1983 and 1985 he was a postdoctoral fellow at Rockefeller
University in the laboratory of Anthony Cerami. He became an Assistant
Professor at Rockefeller University in 1985. He was also an Associate
Physician at the Rockefeller University Hospital between 1984 and 1986.
Beutler returned to Dallas in 1986 as an Assistant Professor in the
Department of Internal Medicine of the University of Texas Southwestern
Medical Center at Dallas, and an Assistant Investigator at the Howard Hughes
Medical Institute, where he retained a position for the next 14 years. He
became an Associate Professor and an Associate Investigator with HHMI in
1990, and a Professor in 1996.
In 2000, Beutler moved to The Scripps Research Institute in La Jolla, CA, as
a Professor in the Department of Immunology. In 2007, he became Chairman of
the newly created Department of Genetics at Scripps. In 2011 he moved back
to UT Southwestern Medical Center to become Director of the Center for the
Genetics of Host Defense.
【在 i***R 的大作中提到】
: 哈哈，校长早上发信，很沾沾自喜的说这个月才把Bruce Beutler又请回来，这就得诺
: 奖了。不过他的开创性工作应该还是在西南做的。
|
i***R
发帖数: 663 | 13 UT Southwestern Scientist Shares 2011 Nobel Prize in Physiology or Medicine
Dr. Bruce A. Beutler, the new Director of the Center for the Genetics of
Host Defense at UT Southwestern Medical Center, today shared the Nobel Prize
in Physiology or Medicine with two other scientists for their discoveries
in how the immune system works.
Dr. Beutler and Dr. Jules A. Hoffmann of Strasbourg University’s Institut
de Biologie Moléculaire et Cellulaire in France shared half the prize for
their discovery of receptor proteins that recognize disease-causing agents
and activate innate immunity, the first step in the body’s immune response.
The other half went to the late Dr. Ralph M. Steinman of Rockefeller
University in New York for his discovery of the dendritic cell and its role
in adaptive immunity.
UT Southwestern faculty members now have won five Nobel Prizes since 1985.
Dr. Michael Brown and Dr. Joseph Goldstein (1985), Dr. Johann Deisenhofer (
1988), Dr. Alfred Gilman (1994) and Dr. Beutler (2011) have been honored by
the Nobel Assembly at Karolinska Institutet in Sweden.
Dr. Beutler, who returned this month to UT Southwestern, where he made his
seminal discoveries, was searching for a receptor able to bind the bacterial
product, lipopolysaccharide (LPS), which can cause life-threatening septic
shock, a condition that involves overstimulation of the immune system.
“It’s a happy day. I’m absolutely delighted. It reaffirms that the time
we spent cloning the LPS receptor gene at UT Southwestern in the 1990s was
time well spent,” Dr. Beutler said.
Dr. Beutler’s original studies at UT Southwestern, where he was a faculty
member and Howard Hughes Medical Institute Investigator from 1986 to 2000,
led to the identification of tumor necrosis factor (TNF) as a key mediation
of inflammation and to the identification of Toll-like receptors as sensors
that act like sentinels to alert the host immune system when infection is
present.
In 1998, Beutler and his colleagues discovered that mice resistant to LPS
had a mutation in a gene that was quite similar to the Toll gene of the
fruit fly. This Toll-like receptor (TLR) turned out to be the elusive LPS
receptor. When it binds LPS, signals are activated that cause inflammation
and, when LPS doses are excessive, results in septic shock. These findings
showed that mammals and fruit flies use similar molecules to activate innate
immunity when encountering pathogenic microorganisms. Dr. Beutler’s
laboratory had discovered the sensors of innate immunity.
The discoveries of Drs. Beutler and Hoffmann triggered an explosion of
research in innate immunity. About a dozen different TLRs have now been
identified in humans and mice.
UT Southwestern President Dr. Daniel Podolsky hailed the impact of Dr.
Beutler’s work on many disease processes.
“His discoveries have led to recognition of a new dimension of immune
response, with profound implications for understanding our ability to
respond to both infectious diseases and cancer. They are already leading to
development of new therapeutic agents that represent new paradigms for
treatment,” Dr. Podolsky said.
“Undoubtedly the powerful genetic approaches that he used in making these
discoveries will continue to yield profound new insights into mechanisms of
molecular function and disease. We are especially delighted by his return to
UT Southwestern where he did his initial groundbreaking work and know that
he will continue in his path of important discovery for many years to come,
” Dr. Podolsky added.
Dr. Greg Fitz, Executive Vice President for Academic Affairs, Provost and
Dean of UT Southwestern Medical School, said, “Dr. Beutler’s scientific
contributions to understanding innate immunity are profound, and already
have opened new vistas into how we respond to bacteria and well beyond. We
are just delighted by this news. He has an incredibly sophisticated approach
, and all of his work from discovery of the LPS receptor gene onward is at
the very highest level. He is now leading a new Center for the Genetics of
Host Defense, and I am convinced that the best may be yet to come.”
Dr. Beutler received the Shaw Prize in Sept. 28 award ceremonies in Hong
Kong, sharing that honor with two other scientists. In 2008, he was elected
to the National Academy of Sciences, and was also named to the Institute of
Medicine.
Prior to his return to UT Southwestern, Dr. Beutler was Chairman of the
Department of Genetics at Scripps Research Institute in La Jolla, Calif.
The medical center’s Nobel history began when Dr. Brown and Dr. Goldstein
received the 1985 Nobel Prize in physiology or medicine for their discovery
of the basic mechanisms of cholesterol metabolism. Their findings led to the
development of the cholesterol-lowering statin drugs.
Dr. Deisenhofer received the Nobel Prize in chemistry in 1988 for using X-
ray crystallography to describe the 3-D structure of a protein molecule.
This structure helped explain the process of photosynthesis.
In 1994 Dr. Gilman received the Nobel Prize in physiology or medicine for
his discovery of G proteins, research that has led to a more complete
understanding of how cells receive signals and respond to external stimuli. |
a****k
发帖数: 1130 | 14 刚看到个截图，转载上来，有意思了哈
【在 i***R 的大作中提到】
: 哈哈，校长早上发信，很沾沾自喜的说这个月才把Bruce Beutler又请回来，这就得诺
: 奖了。不过他的开创性工作应该还是在西南做的。
|
i***R
发帖数: 663 | 15 技术细节，关键看人以后在哪里。现在德州有钱，各方神圣都往这边跑。 |
l*******r
发帖数: 39279 | 16 为什么德州有钱啊？
貌似德州最近是挖了很多牛人
【在 i***R 的大作中提到】
: 技术细节，关键看人以后在哪里。现在德州有钱，各方神圣都往这边跑。
|
p*****m
发帖数: 7030 | 17 挺正常的吧 他phd学校本科学校高中学校没出来说就不错了 估计也快了 呵呵
PS 刚意识到他上的高中居然就是隔壁那个。。
【在 a****k 的大作中提到】
: 刚看到个截图，转载上来，有意思了哈
|
z****g
发帖数: 3340 | 18 俺又多了一个Nobel prize laureate的校友，LOL。
jointly
concerning
Steinman
".
【在 l****t 的大作中提到】
: The 2011 Nobel Prize in Physiology or Medicine was divided, one half jointly
: to Bruce A. Beutler and Jules A. Hoffmann "for their discoveries concerning
: the activation of innate immunity" and the other half to Ralph M. Steinman
: "for his discovery of the dendritic cell and its role in adaptive immunity".
|
s******y
发帖数: 28562 | 19 第一，石油
第二，美国经济中心在往南移
德州有点类似现在的中国，钱多，但是牛人还不够多，所以要从两个传统上
牛人集中营里面（东北和西岸）挖人
【在 l*******r 的大作中提到】
: 为什么德州有钱啊？
: 貌似德州最近是挖了很多牛人
|
i****g
发帖数: 3896 | 20 屠呦呦刚获lasker奖，就有两个中学跑出来宣传了，都说在自己学校读的高中。后来证
实确实高中转学了，两所都读过。但是一所说在本校读了两年，另一所只读了一年。另
外一所也是相同的说法。。还说是因为读不起前一所私立高中才转的学。
【在 p*****m 的大作中提到】
: 挺正常的吧 他phd学校本科学校高中学校没出来说就不错了 估计也快了 呵呵
: PS 刚意识到他上的高中居然就是隔壁那个。。
|
|
|
l*******r
发帖数: 39279 | 21 哦，那么德州不错啊，钱多，房子便宜
对比下可粘的加州
【在 s******y 的大作中提到】
: 第一，石油
: 第二，美国经济中心在往南移
: 德州有点类似现在的中国，钱多，但是牛人还不够多，所以要从两个传统上
: 牛人集中营里面（东北和西岸）挖人
|
h********n
发帖数: 4079 | 22 德州从烟草工业拿了一大笔settlement钱, 用来做研究.
【在 s******y 的大作中提到】
: 第一，石油
: 第二，美国经济中心在往南移
: 德州有点类似现在的中国，钱多，但是牛人还不够多，所以要从两个传统上
: 牛人集中营里面（东北和西岸）挖人
|
i***R
发帖数: 663 | 23 另一方面，德州主张小政府，不似加州那样花钱大手大脚，搞到要破产。
【在 s******y 的大作中提到】
: 第一，石油
: 第二，美国经济中心在往南移
: 德州有点类似现在的中国，钱多，但是牛人还不够多，所以要从两个传统上
: 牛人集中营里面（东北和西岸）挖人
|
g****1
发帖数: 261 | 24
I am glad that you are not a financial analyst :)
【在 s******y 的大作中提到】
: 第一，石油
: 第二，美国经济中心在往南移
: 德州有点类似现在的中国，钱多，但是牛人还不够多，所以要从两个传统上
: 牛人集中营里面（东北和西岸）挖人
|
p*******g
发帖数: 809 | 25 UCSD就快跳出来说了。不过本科的学习对一个人的学术生涯确实有潜移默化的影响。我
自己就深有体会，总是觉得自己的研究态度和品味很受自己本科阶段的影响（可惜本科
是个烂校）。好在后来研究生阶段的2个学校都是国内国外一流学校，算是弥补了一点吧
【在 p*****m 的大作中提到】
: 挺正常的吧 他phd学校本科学校高中学校没出来说就不错了 估计也快了 呵呵
: PS 刚意识到他上的高中居然就是隔壁那个。。
|
S*********s
发帖数: 304 | 26 金爷爷灰爷爷要么是有内幕，要么是有感觉
每次挖完就得奖
【在 a****k 的大作中提到】
: 上来感慨一下老头们又一次刚挖来人就得奖的壮举。。。
: 继续睡去。。。
:
: jointly
: concerning
: Steinman
: ".
|
a****k
发帖数: 1130 | 27 为啥不是挖完再promote得奖呢
【在 S*********s 的大作中提到】
: 金爷爷灰爷爷要么是有内幕，要么是有感觉
: 每次挖完就得奖
|
p*******r
发帖数: 4048 | 28 我觉得有两种人。
一种是他要靠他读过的学校加分。
另一种是他读过的学校靠他加分。
看来你现在是后一种人，恭喜，加油。 ^_^
点吧
【在 p*******g 的大作中提到】
: UCSD就快跳出来说了。不过本科的学习对一个人的学术生涯确实有潜移默化的影响。我
: 自己就深有体会，总是觉得自己的研究态度和品味很受自己本科阶段的影响（可惜本科
: 是个烂校）。好在后来研究生阶段的2个学校都是国内国外一流学校，算是弥补了一点吧
|
P****d
发帖数: 564 | 29 吼吼，想到了有人评价Oswald Avery
【在 p*******r 的大作中提到】
: 我觉得有两种人。
: 一种是他要靠他读过的学校加分。
: 另一种是他读过的学校靠他加分。
: 看来你现在是后一种人，恭喜，加油。 ^_^
:
: 点吧
|
