x********i
发帖数: 248 | 1 童鞋有知道的给解释一下，
这两种都促进体外培养的组织生长吗？根据什么起作用？是什么受体？
跟浓度有关吗？是否浓度太大产生毒性？多大浓度产生毒性？
谢了。 | q*****n
发帖数: 331 | 2 Insulin: insulin receptor
IGF-I: type I IGF receptor
The presence of the receptors in the tissue suggest that insulin or IGF-I
may stimulate their growth.
The binding of the ligands (insulin or IGF-I) will cause receptor
phosphorylation and activation, which in turn, activate downstream signaling
pathways, such as MAPK and Akt.
Use physiological concentration should be fine.
IGF-I: 5nM
insulin: 10-20 nM
If you want detailed information, search pubmed. There are so many reviews
outthere. |
|
