l*********i
发帖数: 332 | 1 神经干细胞与学习和记忆 （全）
－－从journal club说起
一.神经干细胞
我对成年生物大脑内的新神经元生成－－adult neurogenesis一直很有兴趣。正好看到有
人提这篇文章，(thank shuguo!). 我就把我的理解说说，来个journal club。欢迎专
家使劲砸。
Nature Neuroscience - 10, 355 - 362 (2007)
Published online: 4 February 2007;
Preferential incorporation of adult-generated granule cells into spatial
memor
y networks in the dentate gyrus
Nohjin Kee, Cátia M Teixeira, Afra H Wang & Paul W Frankland
文章的介绍提到，以前发现成年动物，比如小鼠和人，大脑的海马里可以不断的产生新神
经元。成年大脑可以不断产生新神经元的部分有三个，海马的dentate gyrus, 嗅球，
和S
ubVentrivul | c****l
发帖数: 1086 | 2 I'm afraid you are wrong,lanceandfei. It's true that there are new new
arrived neurons in mammalian OB throughout whole life. However these new
neurons are generated in SVZ, then migrate through RMS to OB.
One pretty recent interesting finding is this SVZ-RMS-OB neurogenesis also
exists in human brain in which chain of neuron migration was thought to be
not present. (See cover paper of last week Science, groups from New Zealand
and Sweden)
Our lab is focusing on mechanism of tumorigenesis in bra | l*********i
发帖数: 332 | 3 well, hehe, please don't say anything about "may"
i will talk about all you want to talk about in this article, including
Hongjun's work.
i just don't want to put my whole article here for one giant post.
everybody will quit reading it if i do so.
so i will keep posting for about a week, one post every one or two days.
what you see here is just about 1/8.
Hongjun
the | n*********b
发帖数: 140 | 4 The level of adult neurogenesis appears to be inversely correlated with
evolution, i.e. humans have
much lower level of adult neurogenesis. This raises a question of what is
the negative effect of having
new neurons in adult life. If these neurons, if functional, replace more "
experienced" neurons, will adult
neurogenesis compromise the established memory? If the answer is yes, this
may, (sorry no scientist
can do their job without saying "may"), explain the observation of
evolutionarily dec
【在 l*********i 的大作中提到】
: 神经干细胞与学习和记忆 （全）
: －－从journal club说起
: 一.神经干细胞
: 我对成年生物大脑内的新神经元生成－－adult neurogenesis一直很有兴趣。正好看到有
: 人提这篇文章，(thank shuguo!). 我就把我的理解说说，来个journal club。欢迎专
: 家使劲砸。
: Nature Neuroscience - 10, 355 - 362 (2007)
: Published online: 4 February 2007;
: Preferential incorporation of adult-generated granule cells into spatial
: memor
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