d******8
发帖数: 1972 | 1 http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm42
The U.S. Food and Drug Administration today approved Viekira Pak (ombitasvir
, paritaprevir and ritonavir tablets co-packaged with dasabuvir tablets) to
treat patients with chronic hepatitis C virus (HCV) genotype 1 infection,
including those with a type of advanced liver disease called cirrhosis.
Hepatitis C is a viral disease that causes inflammation of the liver that
can lead to reduced liver function, liver failure or liver canc... 阅读全帖 |
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d******8
发帖数: 1972 | 2 http://www.thestreet.com/story/12992120/1/abbvies-hep-c-regimen
Abbvie's Hep C Regimen Approved, Marketing Battle With Gilead Up Next
By: Adam Feuerstein Follow | 12/19/14 - 04:16 PM EST
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Link
Stocks in this article: GILDABBVENTA
U.S. regulators approved a new hepatitis C therapy from Abbvie (ABBV) ,
heralding a new era of market competition with Gilead Sciences (GILD) .
The just-approved Abbvie hepatitis C regimen will be sold in the U.S. under
brand name Viekira Pak. The company... 阅读全帖 |
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c***s
发帖数: 70028 | 3 香港龙城大药房简直成了到港大陆游客的“朝圣地”，出售的产品从药品到染眉毛（和睫毛）的膏应有尽有。即便如此，在全市突然涌现出大量龙城大药房的“山寨版”时，这家夫妻老婆店的店主依然一下慌了阵脚。
据美国彭博新闻社10月8日报道，近年来，以这家有60年历史的老店命名的药店--但并非其附属药房--出现在香港的旅游黄金区，混迹于一连串小药房之中，这些黄金地段距路易威登和香奈儿这样的大牌专卖店仅几分钟的路程。这些较小药房常常霓虹闪烁，为出售的免税药品做广告。
报道称，其货架陈列的商品中包括Muscle Rub（美国基柏强力肌肉镇痛摩擦膏），止痛药，壮阳剂和中药。但是如果你私下里打探，许多药店也会卖给你其它一些东西：抗癌和治疗丙肝的药品--无需出示处方。
多年来，香港以内地购物者在古驰和普拉达等奢侈品专门店选购最新款之地著称。现在，处方药成为它的另一个亮点。
报道称，诸如美国吉利德科技公司治疗丙肝的新药索非布韦片（Sovaldi）、瑞士罗氏控股公司治疗乳腺癌的赫赛汀（Herceptin），这些药在内地要么买不到，要么就更加昂贵。许多内地游客更愿意在香港买药，因为他们认为香港的质量可能更有保证。
一位... 阅读全帖 |
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h****s
发帖数: 16779 | 4 1b型，Sovaldi的治愈率是82%（包括有和没有肝硬化的病人）。对于没有肝硬化的病人
治愈率高于82%。不过要和Olysio合用。
Sovaldi，每天1片，每片的价钱是1000美元，所以12周总价是8万4千美元。
Harvoni再贵12.5%。
貌似这是1b型的standard therapy，总费用都是大概10万美元往上（Olysio 12周也要
大概6万美元）。Viekira Pak和Sovaldi价钱差不多。
Harvoni for 12 weeks**
OR
Olysio + Sovaldi for 12 weeks (no cirrhosis) or 24 weeks (cirrhosis)
OR
Viekira Pak for 12 weeks
(+ ribavirin with cirrhosis)
http://www.hepmag.com/articles/2512_18756.shtml |
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发帖数: 1 | 5 你看有老中faculty 以前在招聘博士后
药化合成 博士后 - 美国 德克萨斯大学 艾尔帕索分校 化学系
Postdoctoral Research Fellow in Synthetic Medicinal Chemistry
Postdoctoral researcher positions are available in the Zhu group at
Department of Chemistry, University of Texas at El Paso (UTEP), to develop
small molecule drug candidates of novel actions for targeted cancer and
cardiovascular disease therapies. The Zhu Group website is: http://science.utep.edu/zhu/ .
Dr. Yaoqiu Zhu got his Ph.D. with Professor Richard Silverman (inventor of
Pfi... 阅读全帖 |
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d******5
发帖数: 4273 | 6 The FDA approves AbbVie's (ABBV) Viekira Pak (ombitasvir, paritaprevir
and ritonavir tablets co-packaged with dasabuvir tablets) for the
treatment of HCV genotype 1 infection, including those with cirrhosis.
gild今天的股价未受此影响，看来这个消息已经price in了。但还需看下周市场反应。 |
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d******5
发帖数: 4273 | 7 The FDA approves AbbVie's (ABBV) Viekira Pak (ombitasvir, paritaprevir
and ritonavir tablets co-packaged with dasabuvir tablets) for the
treatment of HCV genotype 1 infection, including those with cirrhosis.
gild今天的股价未受此影响，看来这个消息已经price in了。但还需看下周市场反应。 |
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d******8
发帖数: 1972 | 8 Dec 19 (Reuters) - U.S. health regulators on Friday approved AbbVie's all-
oral treatment for hepatitis C, providing the first competition for Gilead
Sciences huge selling and expensive medicine for the liver-destroying virus.
The AbbVie regimen consists of four different anti-viral drugs to be taken
as three pills in the morning and one in the evening. The U.S. Food and Drug
Administration approved the regimen, which will be sold under the brand
name Viekira Pak, for patients with genotype 1 fo... 阅读全帖 |
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p*******r
发帖数: 83 | 9 U.S. FDA approves AbbVie all-oral hepatitis C treatment
Dec 19 (Reuters) - U.S. health regulators on Friday approved AbbVie's all-
oral treatment for hepatitis C, providing the first competition for Gilead
Sciences huge selling and expensive medicine for the liver-destroying virus.
The AbbVie regimen consists of four different anti-viral drugs to be taken
as three pills in the morning and one in the evening. The U.S. Food and Drug
Administration approved the regimen, which will be sold under the... 阅读全帖 |
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j********8
发帖数: 2201 | 10 今天ABBV的HCV药批了，晚上ABBV网站上出了press release。
http://tinyurl.com/m7ww522
其中有这么几句话很值得关注，
VIEKIRA PAK is taken for 12 weeks, except in certain GT1a patients with
cirrhosis, who should take it for 24 weeks. Ribavirin should be co-
administered in GT1a patients, and in all patients who have cirrhosis or who
have received a liver transplant.
丙肝有GT1，2，3，4，5，6几种。美国3.2million的病人大概70%是GT1。ABBV的药只批
了GT1。其它的30%的市场目前还是GILD的。
GT1又细分为GT1a和GT1b。我看到的估计是GT1a的病人占了2/3, GT1b占了1/3。一般认
为GT1b比较容易治。上面这句英文是说GT1a的病人如果带有cirrhos... 阅读全帖 |
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T*****n
发帖数: 274 | 11 不知道这个跟Abbvie丙肝药的市场定向有没有关系。Abbvie早先计划收购Shire并将
headquarter转移到欧洲，以避开美国高昂的（35%）的企业税。尽管最后没有成功，但
体现了欧洲市场在他的蓝图之中。相应的，Abbvie Hep C药明年初会在欧洲获批出售。
而从病毒学分类的角度看，美国的HCV只要是GT1a, 欧洲的更多是GT1b。VIEKIRA PAK看
起来对于1b针对性更强。Harvoni的销售绝大部分是在美国。
比较凌乱，可能都是比较牵强的证据，请在制药业的牛人指点。
who |
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c********e
发帖数: 598 | 12 有意思，明明是GILD领先，竟然还有许多波折。病人是不会要VIEKIRA PAK的。 |
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O****N
发帖数: 1458 | 13 Express Scripts to cover AbbVie hepatitis C drug, drops Gilead treatment
Reuters
7 hours ago
By Caroline Humer
Dec 22 (Reuters) - The nation's largest pharmacy benefit manager has
lined up a cheaper price from AbbVie Inc on its newly approved hepatitis C
treatment and, in most cases, will no longer cover Gilead Sciences Inc
treatments, Express Scripts said on Monday.
Express Scripts has opposed the $84,000 pricetag of Gilead Sciences'
Sovaldi treatment since it was approved a year ago, saying th... 阅读全帖 |
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