f**d
发帖数: 768 | 1 这是一本计算神经科学的优秀著作，全文拷贝这里（图和公式缺），有兴趣的同学可以
阅读
如需要，我可以分享PDF文件（－－仅供个人学习，无商业用途）
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖 |
|
h*******v
发帖数: 27 | 2 I read that paper sometime ago. It's a little odd that they examined
striatum instead of cortex. They tried to make a story that cortico-striatal
synapses were sick and other regions were spared (they examined synaptic
plasticity in hippocampus and found it is alright, if I remember correctly).
If so, they should at least rescue the striatum region with virus-delivered
shank3. Without the rescue experiment, no causality is established and the
autistic phenotype could simply be the combined secon... 阅读全帖 |
|
b********n
发帖数: 38600 | 3 http://journal.frontiersin.org/article/10.3389/fpsyg.2014.00852
Introduction
Access to highly palatable and calorically rich foods is a major
contributing factor to the increasing rates of obesity worldwide (Caballero,
2007). Eating is essential for survival and is underpinned by the
fundamental physiological need to consume energy. However, our basic
requirements for nutrients and energy to maintain physiological homeostasis
are often exceeded by an abundant source of readily available and conv... 阅读全帖 |
|
t******l
发帖数: 10908 | 4 [quote]
“Our results raise the question of whether a gene variant favored by
evolution, that would normally confer advantage, may translate into a
disadvantage if the prefrontal cortex is impaired, as in schizophrenia,”
added Daniel Weinberger, M.D. “Normally, enhanced cortex connectivity with
the striatum would provide increased flexibility, working memory capacity
and executive control. But if other genes and environmental events conspire
to render the cortex incapable of handling such informa... 阅读全帖 |
|
J***b
发帖数: 76 | 5 A Postdoctoral Research Associate position is available immediately to study
synaptic transmission/plasticity and alcohol abuse at the Texas A&M Health
Science Center.
Research in the lab uses state-of-the-art technologies, including patch-
clamp recording from genetically identified neurons using transgenic animals
, optogenetics and pharmacogenetics, analysis of structural plasticity using
3-D reconstruction of single neurons in combination with behavioral
procedures. For more details, please ... 阅读全帖 |
|
y****g
发帖数: 3362 | 6 Abutilon striatum
风铃扶桑
扶桑花的亲戚 |
|
l*******8
发帖数: 290 | 7
25) In a patient with a movement disorder , positron emission tomography (
PET), using a radioactive ligand for the dopamine 1 (D-1) receptor, shows a
marked reduction in the structure indicated by the arrow in the MRI of the
normal head. Which of the following is the source of the innervation of this
structure by dopamine-containing axons?
A) Globus pallidus
B) Motor cortex
C) Motor thalamus
D) Striatum
E) Substatia nigra
The arrow in the MRI points to the Caudate Nucleus. |
|
f**d
发帖数: 768 | 8 一些人认为，人们总是可以从失败中学到东西，但大脑的工作原理似乎并非如此。
美国一项最新研究认为，失败的经历几乎对大脑不起作用，脑细胞从成功的经验中
学到更多东西。
美国麻省理工学院的研究人员根据实验中动物脑细胞的不同反应得出以上结论。研
究人员创设了一种独特的“快照”系统，以反映脑细胞的学习过程，在提供正确和
错误行为的信息后，实时拍下单个脑细胞的反应。
研究人员在一份声明中说：“脑细胞可以记录近期的行为是否成功。当某一行为成
~~~~~~~~~~~
功时，脑细胞会针对所学内容进行更加微细的调整。而当失败发生时，脑部几乎没
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
有发生任何变化，行为也没有获得改善。”
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
这项研究成果刊登在美国《神经元》月刊上。（生物谷Bioon.com）
Neuron, Vol... 阅读全帖 |
|
m********a
发帖数: 239 | 9 来自主题: Neuroscience版 - 测试题一个 first: dorsal striatum
third: amygdala
google "multiple memory systems", "Robert McDonald" |
|
J***b
发帖数: 76 | 10 The effect of dopamine on animal behaviors seems very complicated. Dopamine
may via D1 receptors stimulate "Go" neurons in the striatum to facilitate
the section of "Go" action in rewarding behaviors;simultaneously via D2
receptor suppress "No-Go" neurons to inhibit the section of "No-Go" actions.
So the net effect is "Go". This might be why dopamine is so powerful,
although none of dopamine receptors are ion channels. These receptors do not
mediate fast synaptic transmission.
However,naturally ... 阅读全帖 |
|
