m****g
发帖数: 530 | 1 来自主题: _Harvard_Medical_School版 - 小G蛋白RhoA 2009年9月24日，北京生命科学研究所邵峰博士实验室在分子细胞（Molecular Cell）
杂志上发表题为“Cullin
Mediates Degradation of RhoA through Evolutionarily Conserved BTB
Adaptors to Control Actin
Cytoskeleton Structure and Cell Movement”的文章。该文章报道了一个特异性
调节小G蛋白RhoA降解和细胞骨架
及运动能力的新的泛素连接酶复合物。
泛素化修饰介导的蛋白酶体降解途径是真核生物中非常重要的蛋白质调节系统，能够维
持真核细胞内的蛋白质水平的平
衡，同时参与调节细胞周期进程，细胞的增值和分化，以及细胞内信号传导等多种细胞
生理过程。在蛋白质泛素化修饰
过程中，泛素连接酶负责特异性识别和招募底物蛋白分子。Cullin家族蛋白是一类介导
泛素连接酶复合物组装的连接分
子。作为Cullin家族成员之一，Cul3与具有BTB结构域的衔接蛋白组成泛素连接酶复合
物，并结合特异性的底物，介导
底物的泛素化。人 |
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s******h
发帖数: 47 | 2 Can you guys tell me how to stimuate Rac1, Cdc42, and RhoA activation in
vivo in mice?
inject something? what is the dosage? how soon mice can be killed for
collecting sample?
I am assessing the peritoneal macrophage reponse to those activators.
Thanks very much for your help. |
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l*****b
发帖数: 85 | 3 呃，你这一说，我又仔细看了一下，那就是RHOA或是RH0A，13 14SEER写的是RH10A，
15SEER RH0A那个H写得实在是太分开了。谢谢谢谢 |
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l*****b
发帖数: 85 | 4 呃，你这一说，我又仔细看了一下，那就是RHOA或是RH0A，13 14SEER写的是RH10A，
15SEER RH0A那个H写得实在是太分开了。谢谢谢谢 |
|
l**********1
发帖数: 5204 | 5 LZ
please refer
Xu Y et al. (2010)
Connective Tissue Growth Factor in Regulation of RhoA Mediated Cytoskeletal
Tension Associated Osteogenesis of Mouse Adipose-Derived Stromal Cells.
PLoS One. 5: e11279.
http://www.ncbi.nlm.nih.gov/pubmed/20585662
its Fig. 2 B d |
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b******y
发帖数: 627 | 6 what is the dimension of the two figures? Are there many cells or it is part
of a single cell? Is the right one stress fiber? Maybe different small
GTPase, (Rac1, Cdc42 or RhoA), are activated in the two scenarios. |
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S**********e
发帖数: 1789 | 7 给你看看我们系刚进来的助理教授
Vanderbilt University School of Medicine
Fingleton, Barbara Mary , Ph.D. Assistant Professor of Cancer Biology
Publications
Barrett, CW, Fingleton, B, Williams, A, Ning, W, Fischer, MA, Washington, MK
, Chaturvedi, R, Wilson, KT, Hiebert, SW, Williams, CS. MTGR1 is required
for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
Cancer Res, 71(4), 1302-12, 2011.
Koon, HB, Fingleton, B, Lee, JY, Geyer, JT, Cesarman, E, Parise, RA, Egorin,
MJ, Dezube, BJ... 阅读全帖 |
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w***r
发帖数: 709 | 8 Lin HK, Bergmann S, Pandolfi PP (2004) Cytoplasmic PML function in TGF-beta
signaling. Nature. 431, 205- 211. News and Vews by Le Roy C. and Wrana J. L
(2004) Nature. 431, 142. Commented by Kotz J (assistant editor of Nature
Chemical Biology) (2004). Selected as a Featured Article (Sep 2004) in
Nature Signaling Gateway from Nature publishing group.
Lin HK*, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL,
Erdjument-Bromage H, Nimer S, Tempst P, Pandolfi PP* (2009) Phosphorylation-
de... 阅读全帖 |
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r*****m
发帖数: 3619 | 9 Results: 46
Select item 25597018
1.
Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated
Genes in Seminomas.
Cutcutache I, Suzuki Y, Tan IB, Ramgopal S, Zhang S, Ramnarayanan K, Gan A,
Lee HH, Tay ST, Ooi A, Ong CK, Bolthouse JT, Lane BR, Anema JG, Kahnoski RJ,
Tan P, Teh BT, Rozen SG.
Eur Urol. 2015 Jan 14. pii: S0302-2838(14)01396-7. doi: 10.1016/j.eururo.
2014.12.040. [Epub ahead of print]
PMID: 25597018 [PubMed - as supplied by publisher] Free Article
Related citations... 阅读全帖 |
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