b*****d
发帖数: 89 | 1 这怎么和我听说得不完全一样.
从前GENOME的研究, 仅仅有DNA
序列的信息, 对于开发新药是不
够的, 而且原先的药的原理很多都是
把其中的某个蛋白彻底抑制,
可是这个因子在另外的过程中可能
仍然是起好作用的. 所以这样
的药副作用比较大.
PROTEOMICS用 YEAST TWO HYBRID
研究蛋白之间的相互作用.
是在GENOME之后的信息库的建立,
如果新药能抑制蛋白间的相互作用,
而不是完全抑制此蛋白的表达,
对人体副作用小得多.
现在的PROTEOMICS的公司跟CELERA一样,
给制药公司出售信息,这个东西呢,
和CELERA一样, 不可能赚钱,
但是股民们会买股票的, 所以
十年NET LOSS之后, 就又得火别的
www.proteome.com 里有人和其他
模式生物的PROTEOMICS的数据库,
对学校的ISP可能是免费的.
现在被INCYTE 收购了.
PE Biosystems也建立了PROTEOMICS
RESEARCH CENTER, 在5年内, 这个东西是
比较火的 |
|
h*****t
发帖数: 1226 | 2 I do not agree with your definition.
Proteomics, at beginning probably is derivated from protein characterization
,
but it has quite different focus and aspects.
Nowadays, proteomics is not just using mass spec to detect protein/peptides,
a
lot of other techniques have been applied into this area, most importantly
is
Statistics/ Computational biology. And now proteomics is far beyond using
mass spec to detect protein/peptides, like structural proteomics,
interaction
proteomics, subcellular pr |
|
m****n
发帖数: 354 | 3 OK. So we have different views
The definition of protemics is the study of the proteome and the proteome
refers to all the proteins(what kinda proteins and how much is each protein)
in an isolate biological structure. The core of the proteomics is to define
all proteins/peptides under one status. How do you ID a protein? by mass
spectrometry. (list it if you see any other method). Of course, there are a
lot of branches of proteomics. you can put a lot of adjective words to
describe them, such as |
|
P****a
发帖数: 59 | 4 【 以下文字转载自 Biology 讨论区 】
发信人: Papada (乖宝宝), 信区: Biology
标 题: [Help] Look for Peer-review opportunity of proteomics
发信站: BBS 未名空间站 (Wed May 22 10:58:44 2013, 美东)
Major:
In a proteomics/peptide quantification labs for 3 years. Look for peer-
review opportunities in Proteomics Journal for GC application.
Big Bow. |
|
b*******g
发帖数: 1309 | 5 oxford的Prof.Robinson 不算是做proteomics，她做protein structure吧
纯proteomics的有
Scripps John Yates
ETH Ruedi Aebersold
Harvard Steve Gygi
U Virginia Donald F. Hunt
Northwestern U Neil Kelleher
后两个focus在 top-down proteomics
还有其他一些，但是John Yates，Mann，跟Ruedi Aebersold应该是最常提到
另外，Donald F. Hunt 是老先生，john yates 跟neil kelleher都是他的学生/薄厚 |
|
s*****5
发帖数: 52 | 6 【 以下文字转载自 Biology 讨论区 】
发信人: shxm725 (晓晓), 信区: Biology
标 题: 求问蛋白质组学proteomics找工作的问题
关键字: 蛋白质组学，找工作
发信站: BBS 未名空间站 (Sun Feb 1 13:24:02 2015, 美东)
大家好，我博士四年级。做的方向主要是基于LC-MS的proteomics分析，主要负责整个
课题设计，样品处理，数据分析以及给出一些biological story等等。仪器分析这块是
高度固定化的方法，所以这块背景并不是很强。 不想之后再做学术了，想去industry
找工作，但是因为不清楚proteomics这个方向的就业形势到底是怎么样的，job market
是扩大还是缩小。所以发帖来问问，希望有相关领域的前辈能多多指教，万分感谢。
实验室还有一个方向是mAb定量，以及一些蛋白的定向的绝对定量，似乎在工业界更好
找到工作，不知道是不是这样。如果是的话，也在考虑是不是做这个方向。 |
|
k****o
发帖数: 728 | 7 mAb是现在biopharmaceutical industry的宠儿啊。看看job post，哪个大的制药类公
司不招做mAb的？定量也是工业界看中的。另外，懂仪器硬件是王道。不能被“高度固
定化的方法”牵着走。要你牵着方法走。当然，如果你是很懂biology的话那就另说了
。我假定你自己定位在分析、表征这块。
另外，学术界的proteomics大都是做大数据，依赖database search。不是专门做质谱
出生的组往往只懂拿MS做个工具，学生也不大懂原理。而工业界是做single
therapeutic protein的质谱分析多。有一定差别。前者是大数据时代的粗活，后者是
传统的细活。其实你要仔细看招protein MS的职位，很少有说去做proteomics的，因为
by definition proteomics指的是大的data。但总的来说，protein的MS在工业界是成
上升、热门趋势，而且会持续下去。
industry
market |
|
h*****t
发帖数: 1226 | 8 If you looking for "proteomics" jobs, it is tough. Since after serveral
years,
the whole pharm industry did not benefit from "proteomics" much. Thus the
opening for "proteomics" psotisons are less and less.
However, if you have real good Mass Spec experience, you can switch your
direction to protein. peptide, small melucle characterization, PK/PD, etc.
Those kinds have more openings. |
|
s********d
发帖数: 47 | 9 我做proteomics质谱7，8年，背景比楼主差多了。现在也很犯愁。
开始再国内的平台做质谱分析测试，Proteomics样品。
然后在国外博士毕业。
做了一年小分子方向的LCMS。
再接着2年博后，proteomics方面。
现在待业，愁死了。 |
|
w*******t
发帖数: 182 | 10 【 以下文字转载自 Biology 讨论区 】
发信人: whereimat (GreenThumbToBe), 信区: Biology
标 题: 求审稿机会_Mass Spec Proteomics
发信站: BBS 未名空间站 (Thu Aug 23 18:38:20 2012, 美东)
I have several years of experience running mass spectrometer, my focus/
interest is using chemical proteomics to study low abundant signaling
proteins. Thank you very much. |
|
a****Q
发帖数: 83 | 11 已经为 JASMS, J Proteomics, Proteomics, J Trans Med 审过稿。
联系邮箱：c***********[email protected]
谢谢 |
|
G***G
发帖数: 16778 | 12 looking for human tissue proteomics data (mass spectrometry).
where to download it?
requirement: 3 to 5 normal samples
if there is no tissue data, normal cell line is ok.
if there is no normal cell line, plasma is ok.
anyone familiar with chinese liver proteomics project.
where to download their data?
I found one in pride. but the annoation is messed up. i don't know
which data is which sample . even I don't know how many samples they are.
any help?, please. |
|
|
c********d
发帖数: 118 | 14 跟风问一下
那个商业公司做proteomic assay的口碑比较好？
我要初步检测药物处理后，磷酸化蛋白的变化。
联系了我们学校的proteomic core facility，上次给了他们呢一个样品，1个月也没弄
出个结果
这次打算给公司做，有没有值得推荐的？ |
|
h**********r
发帖数: 671 | 15 Global Proteomics Reveal an Atypical Strategy for Carbon/Nitrogen
Assimilation by a Cyanobacterium Under Diverse Environmental Perturbations
Mol Cell Proteomics 2010 9: 2678-2689. First Published on September 21, 2010
, doi:10.1074/mcp.M110.000109
Abstract Full Text Full Text (PDF) Supplemental Data
You may send it to m******[email protected]
Thanks and have a nice weekend! |
|
w****s
发帖数: 235 | 16
in
what has been worked out for "clinical proteomics"? biomarker discovery was
a joke long time ago ,now the instrument gets more sensitive but dynamic
range is still a major challenge..I heard Ruedi was working on the topic he
knows well how to sell ideas but I did not hear anything exciting.any solid
idea that one could do with clinical proteomics? |
|
r***u
发帖数: 11 | 17 A Post-Doctoral Research Fellow position is available in the Department of
Chemistry and Biochemistry at the Georgia Institute of Technology.
Our researches are about LC-MS based proteomic method developments,
especially for protein post-translational modifications, and their
applications on biomedical studies. You could find more by going to the
following link or contacting me ( http://www.chemistry.gatech.edu/faculty/Wu/ ).
Ideal candidate has strong research background and experience with HPL... 阅读全帖 |
|
P****a
发帖数: 59 | 18 Major:
In a proteomics/peptide quantification labs for 3 years. Look for peer-
review opportunities in Proteomics Journal for GC application.
Big Bow. |
|
s******s
发帖数: 1584 | 19 Expert Rev Proteomics. 2011 Feb;8(1):127-36. doi: 10.1586/epr.10.97.
Profiling for novel proteomics biomarkers in neurodevelopmental disorders.
Dudley E, Hässler F, Thome J.
Institute of Mass Spectrometry, School of Medicine, Swansea University,
Swansea, UK.
s*******[email protected]
谢谢~ |
|
s*****5
发帖数: 52 | 20 大家好，我博士四年级。做的方向主要是基于LC-MS的proteomics分析，主要负责整个
课题设计，样品处理，数据分析以及给出一些biological story等等。仪器分析这块是
高度固定化的方法，所以这块背景并不是很强。 不想之后再做学术了，想去industry
找工作，但是因为不清楚proteomics这个方向的就业形势到底是怎么样的，job market
是扩大还是缩小。所以发帖来问问，希望有相关领域的前辈能多多指教，万分感谢。
实验室还有一个方向是mAb定量，以及一些蛋白的定向的绝对定量，似乎在工业界更好
找到工作，不知道是不是这样。如果是的话，也在考虑是不是做这个方向。 |
|
s*****5
发帖数: 52 | 21 大家好，我博士四年级。做的方向主要是基于LC-MS的proteomics分析，主要负责整个
课题设计，样品处理，数据分析以及给出一些biological story等等。仪器分析这块是
高度固定化的方法，所以这块背景并不是很强。 不想之后再做学术了，想去industry
找工作，但是因为不清楚proteomics这个方向的就业形势到底是怎么样的，job market
是扩大还是缩小。所以发帖来问问，希望有相关领域的前辈能多多指教，万分感谢。
实验室还有一个方向是mAb定量，以及一些蛋白的定向的绝对定量，似乎在工业界更好
找到工作，不知道是不是这样。如果是的话，也在考虑是不是做这个方向。 |
|
z*********s
发帖数: 38 | 22 Expert Rev Proteomics. 2015 Jul 16:1-13. [Epub ahead of print]
High-throughput screening of cellular redox sensors using modern redox
proteomics approaches.
Jiang J1, Wang K, Nice EC, Zhang T, Huang C. |
|
B8
发帖数: 92 | 23 The Department of Environmental Sciences and Engineering at Gillings School
of GlobalPublic Health, University of North Carolina at Chapel Hill has a
postdoc opening. We are looking for a self-motivated postdoc to conduct
omics profiling to understand the interactions between the gut microbiome
and diseases/environmental exposures. Our lab has dedicated high-end mass
spectrometers, including Q-Exactive HF Orbitrap and 6550 Q-TOF.
A PhD degree or solid training in analytical chemistry, proteomics... 阅读全帖 |
|
发帖数: 1 | 24 最好能尽快开始工作，感兴趣的请给我发站内邮件。
我们公司（Impossible Foods）是湾区南半岛的中等规模生物技术公司，首个产品刚上
市，正在迅速扩张中。希望你有两年以上的蛋白质组学经验，最好受过系统的生物化学
教育。请在邮件中简单介绍一下自己，并附上你的email。我会尽快和你联系。
Research Associate- Biochemistry and Proteomics at Impossible Foods (View
all jobs)
Redwood City, California
Impossible Foods is leading the way to a sustainable global food system. We
are developing transformative new technologies to produce great plant-based
foods that outperform existing meat and dairy products in taste and
nutrition, at a lower c... 阅读全帖 |
|
s********l
发帖数: 1195 | 25 Mol Cell Proteomics. 2010 Jun;9(6):1324-38. Epub 2010 Mar 11.
Proteomics analysis of bladder cancer exosomes.
Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD,
Clayton A.
Section of Oncology and Palliative Medicine, Department of Pharmacology,
Oncology and Radiology, School of Medicine, Cardiff University, Velindre
Cancer Centre, Whitchurch, Cardiff CF14 2TL, United Kingdom.
Thanks! |
|
h*****t
发帖数: 1226 | 26 Yes. Mass spec play s an important role in proteomics, like what you said
ID proteins. However, Proteomics is not protein characterization.
Just to clearify this single point.
protein)
define
a
discovery. |
|
w********g
发帖数: 447 | 27 我做LC-MS小分子的，看proteomics的paper老是看的晕晕乎乎的，我楼下做LC-MS
proteomics的，说看小分子LC-MS的paper那叫一个easy啊。That's the difference,:) |
|
w********g
发帖数: 447 | 28 其实解proteomics的谱我也知道一些（解过不下100个谱），看paper得时候那些
proteomics的东西让我confused不是mass spec的部分，是那些bio的东西。相对来说小
分子的东西更chemistry一点，比较straightforward。
how
the
it |
|
k****i
发帖数: 1126 | 29 I used to do proteomics in graduate school. I would suggest you to read a
few reviews in the field which you can find on pubmed. I don't see this is a
mature technique and eventually I gave up my proteomics project and did
something else to graduate. |
|
E*****c
发帖数: 47 | 30 TOP 5 pharmaceutical at Cambridge, looking for a Ph.D. level investigator
focusing on the affinity proteomics (including interactomics, chemical
proteomics etc.) with around 2-6 years academic or industrial experience.
Position will soon be open to public within next couple weeks. If interested
, please send CV to z*****[email protected] and I will forward the CV to the
hiring manager. |
|
r***u
发帖数: 11 | 31 A Post-Doctoral Research Fellow position is available in the Department of
Chemistry and Biochemistry at the Georgia Institute of Technology.
Our researches are about LC-MS based proteomic method developments,
especially for protein post-translational modifications, and their
applications on biomedical studies. You could find more by going to the
following link or contacting me ( http://www.chemistry.gatech.edu/faculty/Wu/ ).
Ideal candidate has strong research background and experience with HPL... 阅读全帖 |
|
J******o
发帖数: 6 | 32 杂志 Drug Target Insights is looking for 4 个 guest editor, 每个editor 需要
征集5篇PAPER， topics 是关于 Gene Therapy and Proteomics. 有兴趣的junior
scientists 留下email. 对申请EB1A有帮助。我是lead guest editor, 也是为了申请
绿卡用才做的。大家互相帮忙. |
|
k****o
发帖数: 728 | 33 proteomics的journal就那几个，范围也窄。你可以瞄准general anal chem，mass
spec, separation science等journal，不下一二十。你要是偏生物的话，还有生物的
杂志可以骚扰。 |
|
m*******9
发帖数: 868 | 34 [gone]第一篇：英文，关键词：Proteomics， obesity，histone deacetylase 4 (
HDAC4)
第二篇：中文文章，有关微生物基因组的
请站内联系 |
|
k****o
发帖数: 728 | 35 一个Proteomics/Genomics 方面的open access journal，我正在handle一个稿子，需
要寻找几个reviewers。文章title/abstract如下。杂志也不是多好，但也能派上用场
。感兴趣的可站内联系，我需要尽快发出邀请，已经拖了几天了。
请给出name, institute, position, email, expertise, and representative
publications related to this manuscript.
Article Title : Classification of non-animals and invertebrates based on
amino acid composition of complete mitochondrial genomes
Abstract :
Amino acid compositions were predicted from data sets of 47 non-animal and
58 invertebrate animal complete mit... 阅读全帖 |
|
b********2
发帖数: 125 | 36 审稿是短板，最近有些时间，想多审几篇为申请绿卡做准备。
希望能得到前辈推荐，先在这里谢过了！
我的方向是
1. biochemistry and proteomics in epigentics
2. biosynthesis, enzyme kinetics and reaction mechanism |
|
J******o
发帖数: 6 | 37 杂志 Drug Target Insights is looking for 4 个 guest editor, 每个editor 需要
征集5篇PAPER， topics 是关于 Gene Therapy and Proteomics. 有兴趣的junior
scientists 留下email. 对申请EB1A有帮助。我是lead guest editor, 也是为了申请
绿卡用才做的。大家互相帮忙. |
|
A*F
发帖数: 2272 | 38 需要proteomics, genomics分析方向的审稿人
请将简历或者近期发表文章列表发到[email protected]
/* */
谢谢 |
|
发帖数: 1 | 39 为了穿绿衣服，求个审稿，专业是proteomics and protein chemistry. 谢谢大家 |
|
d*******d
发帖数: 25 | 40 文章偏Proteomic analysis and bioinformatics
可以向编辑推荐你.站内注明你的关键词(英文)，institution email,姓
名.LinkedIn or website if possible. |
|
D********r
发帖数: 135 | 41 【 以下文字转载自 Biology 讨论区 】
发信人: DreamTiger (钟爱你一生), 信区: Biology
标 题: 求审稿机会（Bioinformatics in Genomics and Proteomics）
发信站: BBS 未名空间站 (Tue Mar 21 20:26:46 2017, 美东)
急求审稿机会，基因组生物信息学或者蛋白质组生物信息学，站内联系，多谢。 |
|
b*****0
发帖数: 142 | 42 现在我这里有一篇关于Cancer Proteomics 方面的稿子，需要2-3名reviewers。如果有
这方面需求的可以把联系我，附上简短的简历，如果合适对口，我会直接联系你正式邀
请。
我是editorial board member, 所以不定期的会有关于cancer biology 方面的稿子要
处理。 |
|
c******t
发帖数: 1162 | 43 好人啊！多谢。
求内推呀。本人PhD毕业，有mass spec和proteomics 四年经验，已发表第一作者论文一
篇，IF大于6. |
|
P****A
发帖数: 55 | 44 【 以下文字转载自 Overseas 讨论区,原文如下 】
发信人: phdusa (出国迷), 信区: Overseas
标 题: Post-Docs.com => Postdoc Proteomics/Genomics
发信站: The unknown SPACE (Sat Feb 24 23:52:56 2001) WWW-POST
Postdoc positions posted on the post-doctoral website:
http://www.post-docs.com |
|
P****A
发帖数: 55 | 45 【 以下文字转载自 Overseas 讨论区,原文如下 】
发信人: phdusa (出国迷), 信区: Overseas
标 题: Post-Docs.com => Postdoc Proteomics/Genomics
发信站: The unknown SPACE (Sat Feb 24 23:52:56 2001) WWW-POST
Postdoc positions posted on the post-doctoral website:
http://www.post-docs.com |
|
P****A
发帖数: 55 | 46 【 以下文字转载自 Overseas 讨论区,原文如下 】
发信人: phdusa (出国迷), 信区: Overseas
标 题: Post-Docs.com => Postdoc Proteomics/Genomics
发信站: The unknown SPACE (Sat Feb 24 23:52:56 2001) WWW-POST
Postdoc positions posted on the post-doctoral website:
http://www.post-docs.com |
|
P****A
发帖数: 55 | 47 【 以下文字转载自 Overseas 讨论区,原文如下 】
发信人: phdusa (出国迷), 信区: Overseas
标 题: Post-Docs.com => Postdoc Proteomics/Genomics
发信站: The unknown SPACE (Sat Feb 24 23:52:56 2001) WWW-POST
Postdoc positions posted on the post-doctoral website:
http://www.post-docs.com |
|
m****n
发帖数: 354 | 48 吓大兄弟姐妹，有多少人在做proteomics方面的啊?
知道的好像就hooligan老兄，还有Mac是吧
能不能介绍一下这方面的就业情况啊。//bow
还有就是laoniu很就没有联系了，在哪里高就呢？ |
|
h******n
发帖数: 493 | 49 proteomics在公司里的就业情况我觉得不算好。
如果你的mass spec方面比较强，不管是偏生物大分子
分析，还是小分子分析，甚至是偏仪器的，都应该比
较好找。多去ASMS的那个job list看看吧。
我觉得这两个月有很多工作贴出来的。。。
Good Luck! |
|
b*********t
发帖数: 65 | 50 小人才潜，只是知道个大概，PROTEOMICS是指
用分析的手段来表征一个生物体(或一种CELL)里的
所有蛋白。
现在作的最好的都是用MS的方法。也有尝试用
PROTEIN CHIPS的，不过还无法与MS的方法竞争。
一般MS用的是先DIGEST，然后在用MS(一般是MALDI)
这叫BOTTOM UP，方法很成熟，AUTOMATION的很好，
在这里又分2D-GEL和2D-LC/MS
AEBERSOLD R和YATES JR都是这种牛人
令一类的是想作完整的蛋白，即偶们老板的所谓的
TOP-DOWN方法，基本上是不用DIGESTION。现在这方面的
PAPER还不多，影响也不大。 |
|
