C*I
发帖数: 4736 | 1 发信人: Huangchong (净坛使者), 信区: Joke
标 题: 石正丽2015论文
发信站: BBS 未名空间站 (Thu Feb 6 19:21:33 2020, 美东)
摘要
sars和mers的出现表明跨物种传播病毒对人类具有威胁。
这里我们研究一种在中国马蹄蝙蝠里流行的SARS-相似病毒，SHC014。
使用SARS冠毒的反向遗传系统，我们把SHC014的spike蛋白装在了一个可以在老鼠里复
制的SARS病毒框架上，并对它进行了一些研究。这些结果显示，SHC014所属的2b类病毒
可以使用SARS的人类受体，ACE2。这种病毒可以在来自人的呼吸道的原代细胞里高效增
殖，达到跟SARS病毒类似的病毒滴度。而且，体内实验表明这个人工病毒可以在老鼠肺
里产生病理效果。
对现有的抗SARS免疫疗法和其他疗法的测试显示，这些方法都不太有效。抗SARS的单抗
没有中和病毒，抗SARS的疫苗没有产生有效的免疫效果。
（总结）我们造了一种全长的SHC014重组病毒，并证明它可以在老鼠体内和细胞培养的
条件下有效复制。我们的工作提示SARS有可能再次从蝙蝠病毒传到人类。
（说明... 阅读全帖 |
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c**********0
发帖数: 836 | 7 Chinese officials said an additional 26 people died from the novel
coronavirus on Tuesday, bringing the virus' overall death toll to 132.
Twenty-five of the new deaths came from Hubei province, the epicenter of the
outbreak; the final death occurred in Henan province.
Officials also reported 1,459 new confirmed cases, bringing the total to 5,
974. More than 1,200 of those cases are considered "critical." |
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C*I
发帖数: 4736 | 8 一直在误导，现在还在误导。 说说明corona virus 不可以从蝙蝠直接传染给人，必须
经过一个中间宿体性的其它动物才能传染给人。所以，病毒发生后，就故意误导全国人
民去海鲜市场找证据，找其它野生动物的麻烦。 而且还是病毒所去找的，找完了还装
模做样化验呀，分离呀什么的。最后把责任全部推给了海鲜市场的动物。可是那种动物
，一直不敢说，说了其它相关已经在人就会去早那种动物监测。 所以压根不说，打马
虎眼。
事实上，早在2013 年，就是这个武汉病毒研究所，已经从来自云南的蝙蝠身上所携带
的corona virus中分离出第一株蝙蝠SARS类似样的冠状病毒的活病毒，其中就包含了类
似于S类型的基因。从而证实这株病毒能够使其接受和SARS病毒相同的受体，并能够感
染人的细胞。对此新发现，武汉病毒所还把它以武汉病毒研究所的英文简称命名“WIV1
”，以彰显这一发现的重要价值和属于自己第一个发现的巨大研究成果。这个成果刊载
于2013年11月的《自然》杂志。
就是说，从云南弄回来的这种蝙蝠所携带的类似于sars的 corona virus， 可以不经过
其它受体/宿体，而直接传染给人。 他们... 阅读全帖 |
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C*I
发帖数: 4736 | 9 发信人: Huangchong (净坛使者), 信区: Joke
标 题: 石正丽2015论文
发信站: BBS 未名空间站 (Thu Feb 6 19:21:33 2020, 美东)
摘要
sars和mers的出现表明跨物种传播病毒对人类具有威胁。
这里我们研究一种在中国马蹄蝙蝠里流行的SARS-相似病毒，SHC014。
使用SARS冠毒的反向遗传系统，我们把SHC014的spike蛋白装在了一个可以在老鼠里复
制的SARS病毒框架上，并对它进行了一些研究。这些结果显示，SHC014所属的2b类病毒
可以使用SARS的人类受体，ACE2。这种病毒可以在来自人的呼吸道的原代细胞里高效增
殖，达到跟SARS病毒类似的病毒滴度。而且，体内实验表明这个人工病毒可以在老鼠肺
里产生病理效果。
对现有的抗SARS免疫疗法和其他疗法的测试显示，这些方法都不太有效。抗SARS的单抗
没有中和病毒，抗SARS的疫苗没有产生有效的免疫效果。
（总结）我们造了一种全长的SHC014重组病毒，并证明它可以在老鼠体内和细胞培养的
条件下有效复制。我们的工作提示SARS有可能再次从蝙蝠病毒传到人类。
（说明... 阅读全帖 |
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t******r
发帖数: 8600 | 10 Health officials monitoring the coronavirus in the U.S. said there are
currently 110 “persons under investigation” across 26 states, noting that
the number “will only increase” as the outbreak in China continues. The
Centers for Disease Control and Prevention (CDC) said in an update on Monday
that five of the cases in the U.S. tested positive for the novel
coronavirus, or 2019-nCoV, and 32 so far had produced negative results. |
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X1
发帖数: 1823 | 11 Russia closes China border as outbreak tops 7,900 cases with 170 deaths |
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发帖数: 1 | 12 16年了原地打转。
还是一出事赶紧分钱。
搞疫苗和控制outbreak一分钱关系都没有。在时间维度不是一个数量级，一个以天算，
一个以年算。
央视和专家还在吹。 |
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m**********n
发帖数: 27535 | 13 The great waves of plague that twice devastated Europe and changed the
course of history had their origins in China, a team of medical geneticists
reported Sunday, as did a third plague outbreak that struck less harmfully
in the 19th century.
https://www.nytimes.com/2010/11/01/health/01plague.html |
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m**********n
发帖数: 27535 | 14 The great waves of plague that twice devastated Europe and changed the
course of history had their origins in China, a team of medical geneticists
reported Sunday, as did a third plague outbreak that struck less harmfully
in the 19th century.
最后一段是重点：
The likely origin of the plague in China has nothing to do with its people
or crowded cities, Dr. Achtman said. The bacterium has no interest in people
, whom it slaughters by accident. Its natural hosts are various species of
rodent such as marmo... 阅读全帖 |
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d*********o
发帖数: 6388 | 15 https://www.cnbc.com/2020/01/30/who-declares-china-coronavirus-a-global-
health-emergency.html
The World Health Organization said the fast-spreading coronavirus that’s
infected more than 8,200 across the world is a global health emergency — a
rare designation that helps the international agency mobilize financial and
political support to contain the outbreak.
The announcement comes just hours after the U.S. confirmed its first human-
to-human transmission of the virus, which has killed at least ... 阅读全帖 |
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发帖数: 1 | 17 都是事实
没有编造
: 你编造WHO 的声明 没用的
: 自欺欺人
: 发信人: gxfcdjdl (Ёб твою мать), 信区: Military
: 标 题: Re: 老将气疯！WHO对中国政府赞赏有加
: 发信站: BBS 未名空间站 (Thu Jan 30 17:00:46 2020, 美东)
: "China is actually setting a new standard for outbreak response."
: 米帝的社会动员力，无论如何在其灭亡之前无法超越窝鳖的
: 你们老将悲愤没用
: second-
: committee-
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发帖数: 1 | 18 老黑拿钱没办成事，只能嘴甜说两句，五毛立刻向捡到宝似的，捧起黑洋人的臭脚猛亲
，一点都不嫌弃！真让人想吐！
：China’s response to the outbreak has been “very impressive,” the WHO
：chief added. “So is China’s commitment to transparency and to supporting |
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发帖数: 1 | 19 你有证据吗？
人家WHO是有皿煮证的组织，你们狗粮不好这么随便造谣的
LOL
: 老黑拿钱没办成事，只能嘴甜说两句，五毛立刻向捡到宝似的，捧起黑洋人的臭
脚猛亲
: ，一点都不嫌弃！真让人想吐！
: ：China’s response to the outbreak has been “very impressive,” the
WHO
: ：chief added. “So is China’s commitment to transparency and to
supporting
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r****t
发帖数: 212 | 20 Case fatality rate (CFR) – or case fatality risk, case fatality ratio or
just fatality rate – is the proportion of deaths within a designated
population of "cases" (people with a medical condition) over the course of
the disease. A CFR is conventionally expressed as a percentage and
represents a measure of risk. CFRs are most often used for diseases with
discrete, limited time courses, such as outbreaks of acute infections.
For example: Assume 9 deaths among 100 people in a community all diagnos... 阅读全帖 |
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i*****9
发帖数: 698 | 23 China Travel Advisory
Travel Advisory
January 30, 2020China - Level 4: Do Not Travel
Do not travel to China due to novel coronavirus first identified in Wuhan,
China. On January 30, the World Health Organization has determined the
rapidly spreading outbreak constitutes a Public Health Emergency of
International Concern. Travelers should be prepared for travel restrictions
to be put into effect with little or no advance notice. Commercial carriers
have reduced or suspended routes to and from Chi... 阅读全帖 |
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发帖数: 1 | 24 The Trump administration on Friday declared a U.S. public health emergency
over the coronavirus outbreak, saying it would bar foreign nationals who
have set foot in China in the last 14 days from entering the United States
and impose other measures on Americans returning from the country.
.
The ban applies to “foreign nationals, other than immediate family of U.S.
citizens and permanent residents, who have traveled in China within the last
14 days,” Azar said. It will take effect at 5 p.m. Sunda... 阅读全帖 |
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发帖数: 1 | 25 艹，英语就是低级语言
：The Trump administration on Friday declared a U.S. public health emergency
：over the coronavirus outbreak, saying it would bar foreign nationals who |
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发帖数: 1 | 26 下周开始回流，打工上班的，上亿人流。
目测下周末失控，大面积感染。下下周末上演现实版outbreak，满大街都是躺着的，彻
底失控。
最迟二月底，全世界宣布中国为疫区，对中国封锁。
后面你们自己想想都可以了。 |
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发帖数: 1 | 27 http://theprepared.com/blog/no-the-2019-ncov-genome-doesnt-actually-seem-engineered-from-hiv/
2019-nCoV genome doesn’t really seem engineered from HIV
A group of bioinformaticians at two prestigious universities in Delhi, India
, published a preprint scientific manuscript on the bioRxiv preprint server
Friday has led many to speculate wildly that 2019-nCoV may have been
deliberately engineered using HIV protein sequences.
The paper, entitled “Uncanny similarity of unique inserts in the 2019-nCoV... 阅读全帖 |
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发帖数: 1 | 28 加拿大粉红韭菜就喜欢造谣，他包叔格外高兴
The Centers for Disease Control and Prevention (CDC) today confirmed that
the 2019 Novel Coronavirus (2019-nCoV) has spread between two people in the
United States, representing the first instance of person-to-person spread
with this new virus here.
Previously, all confirmed U.S. cases had been associated with travel to
Wuhan, China, where an outbreak of respiratory illness caused by this novel
coronavirus has been ongoing since December 2019. However, this latest 2019-
nCoV... 阅读全帖 |
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m*********w
发帖数: 376 | 29 先打出两周的损失
SHANGHAI (Reuters) - China's central bank said it will inject 1.2 trillion
yuan ($174 billion) worth of liquidity into the markets via reverse repo
operations on Monday as its stock markets prepare to reopen amid an outbreak
of a new coronavirus. |
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k*****x
发帖数: 713 | 30 一万两千亿杯水车薪，后面至少加个零
outbreak |
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o*******a
发帖数: 242 | 31 Very suspicious.
Must investigate the institute and the laboratory carefully for all possible
source of outbreak |
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S******r
发帖数: 4421 | 32 1月23日，中国科学院武汉病毒研究所发表论文揭示：武汉新型冠状病毒nCoV-2019与一
种蝙蝠中的冠状病毒的序列一致性高达96%。
以上成果来自中国科学院武汉病毒研究所石正丽团队1月23日在bioRxiv预印版平台上发
表的Discovery of a novel coronavirus associated with the recent pneumonia
outbreak in humans and its potential bat origin。
忙不迭发文章 不打自招 这个也是匪夷所思
https://www.thepaper.cn/newsDetail_forward_5621318 |
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发帖数: 1 | 33 Fall and winter are the quintessential cooking seasons. They're prime for
preparing whole roasts, baking cookies, and sipping hot cocoa. But this time
of year puts a lot of our favorite foods in high demand just as they're
experiencing shortages, foodborned illness outbreaks, and more. According to
the Consumer Price Index issued by the USDA and the U.S. Bureau of Labor
Statistics (BLS), there are eight foods in particular that you should be
wary of when it comes to price tags during your weekly... 阅读全帖 |
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a*******m
发帖数: 14194 | 34 还Google来反驳，大家是第一手资料好不好?
去年的冬天比今年还冷好不好?
你这种general info，有个屌用啊？
: Fall and winter are the quintessential cooking seasons. They're prime
for
: preparing whole roasts, baking cookies, and sipping hot cocoa. But
this time
: of year puts a lot of our favorite foods in high demand just as they'
re
: experiencing shortages, foodborned illness outbreaks, and more.
According to
: the Consumer Price Index issued by the USDA and the U.S. Bureau of
Labor
: Statistics (BLS), there a... 阅读全帖 |
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S******r
发帖数: 4421 | 35 难道是想发paper想疯了？
https://www.thepaper.cn/newsDetail_forward_5621318
1月23日，中国科学院武汉病毒研究所发表论文揭示：武汉新型冠状病毒nCoV-2019与一
种蝙蝠中的冠状病毒的序列一致性高达96%。
以上成果来自中国科学院武汉病毒研究所石正丽团队1月23日在bioRxiv预印版平台上发
表的Discovery of a novel coronavirus associated with the recent pneumonia
outbreak in humans and its potential bat origin。 |
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p***n
发帖数: 17190 | 37 https://www.msn.com/en-us/news/world/china-says-urgent-need-for-medical-
equipment-as-virus-toll-tops-sars/ar-BBZAob5
China says 'urgent' need for medical equipment as virus toll tops SARS
AFP 1 hr ago
US Coast Guard: Texas oil spill has restarted
Appeal of man who shot Army recruiters rejected
Click to expand
China said Monday it urgently needed medical equipment and surgical masks as
the death toll from a new coronavirus jumped above 360, making it more
deadly than the SARS crisis nearly two d... 阅读全帖 |
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f***y
发帖数: 4447 | 38 《自然》首次发表新冠论文：武汉病毒所确认病毒进入细胞路径
2020-02-03 22:23:02
北京时间2月3日傍晚，国际顶级学术期刊《自然》（Nature）以“加快评审文章”(
Accelerated Article Preview)形式在线发表了中国科学院武汉病毒研究所石正丽团队
关于新型冠状病毒（2019-nCoV）的研究论文，该论文于2020年1月20日提交，1月29日
被期刊接收，最终在线发表于2月3日。这也是《自然》首次以正式论文的形式刊发关于
2019-nCoV的研究。
石正丽团队对最早在中国武汉引发呼吸系统疾病暴发的一种新型冠状病毒进行了鉴定和
表征，揭示了其与严重急性呼吸综合征（SARS）冠状病毒的相似性。研究团队发现了新
型冠状病毒来源于蝙蝠的证据，但是此次爆发的动物来源尚待确认。武汉病毒所还确认
了2019-nCoV进入细胞的路径与SARS冠状病毒一样，即通过ACE2细胞受体。
冠状病毒一直是人类传染病流行的一个来源，严重急性呼吸综合征（SARS）和中东呼吸
综合征（MERS）都是由冠状病毒引起。而SARS相关的冠状病毒主要是在蝙蝠等哺乳动物
体内被发现的，对公... 阅读全帖 |
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发帖数: 1 | 39 CDC says it is still waiting on invitation from China to assist with
coronavirus outbreak
怎么回事？
大国撅起，不需要美帝帮助了？ |
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S*******l
发帖数: 4637 | 40 https://www.wsj.com/articles/the-flu-is-hitting-children-especially-hard-
this-season-11580750592?mod=hp_lead_pos11
The Flu Is Hitting Children Especially Hard This Season
Coronavirus dominates attention, but the more widespread flu has already
killed thousands across all ages, and is infecting kids at unusually high
rates
Overall, there have been at least 19 million U.S. cases of the flu this
season, 180,000 hospitalizations, and 10,000 deaths, according to
preliminary estimates from the CDC. T... 阅读全帖 |
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发帖数: 1 | 42 "KNOCK DOWN the idea the pathogen came from a virology institute in Wuhan"
有不服的文盲半文盲请继续。
“One of the biggest takeaway messages [from the viral sequences] is that
there was a single introduction into humans and then human-to-human spread,
” says Trevor Bedford, a bioinformatics specialist at the University of
Washington and Fred Hutchinson Cancer Research Center. The role of Huanan
Seafood Wholesale Market in Wuhan, China, in spreading 2019-nCoV remains
murky, though such sequencing, combined wit... 阅读全帖 |
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b*********3
发帖数: 1709 | 50 If you want to believe a guy connected to the same intelligence agency that
was behind Epstein's sex blackmail op about the origins of the coronavirus
outbreak (China), be my guest, but I won't be joining in
The claims of this "Israeli military intelligence doctor" oddly take
pressure off of the reports that have been linking the Gates Foundation to
coronavirus simulations and patents. Who was good friends w Bill Gates again?
https://twitter.com/_whitneywebb/status/1221202391313395713 |
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