U*****e
发帖数: 2882 | 1 缺药这事和美国政府没有直接关系。
http://theincidentaleconomist.com/wordpress/why-is-there-a-propofol-shortage-in-a-free-market/
Some time ago, three companies made propofol: Teva Pharmaceuticals, Hospira,
and APP Pharmaceuticals. But starting last October, the dominoes began to
fall. First, Hospira was forced to recall multiple batches of its drug
because of contaminants in vials. Soon after, Teva was forced to recall
multiple batches of the drug because of possible microbial contamination.
Instead of reco |
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p********3
发帖数: 5750 | 2 50， 70， 71； 大家注意一下和这几篇文献相关的话题。 另外， 73-75我本人没有看，确实是谈的印度药材， 我在查阅参考文献的时候在搜索Chinese Medicine的时候， 显示有这些文献，我本人没有亲自看这些文献， 也许其中有讲中药的地方。不过这不影响我要表达的意思。
慢慢看：
INTRODUCTION — Plants have been used for medicinal purposes for thousands
of years. All major cultures including Native American, European, South
American, Asian, and African cultures have used botanicals for healing
purposes. As an example, saw palmetto was used for urinary symptoms in men
from Egypt in the 15th century BC [1]. Hippocrates documented... 阅读全帖 |
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w*l
发帖数: 2550 | 3 12/15/2006
关于科学研究诚信的公开信 (傅新元等120人连署)
尊敬的：教育部部长周济 科技部部长徐冠华 中国科学院院长路甬祥 国家自然科学基
金委员会主任陈宜瑜
作为科技工作者，我们十分关切国内近来多起有关学术研究不端的指控事件。我们愿意
针对科学研究诚信的重要问题表示如下观点：
1. 我们反对任何形式的学术不端行为，并强烈主张一个科技工作者应当保持高标准的
学术道德规范。我们支持揭露任何形式的学术不端。与此同时，要确证学术不端的 案
例，我们必须遵循合法和适当的调查程序。例如，美国公共卫生署关于学术研究不端行
为的处理指南规定，对学术研究不端行为指控的调查，起初应当是非公开 的，其首先
应当由所涉及机构的内部委员会调查并处理。“无罪假定 (Innocent until proven
guilty)”是我们在调查学术不端的指控时必须遵守的一个重要原则。
2. 如果争论或指控不能够在该研究机构内部解决，那么，更高的主管部门和基金支持
机构或专业协会应当介入，建立外部调查委员会，直到问题得到圆满解决。在调查 期
间，不论是指控者或被指控者，都应受到合法保护，其身份应该保密。被指... 阅读全帖 |
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w******e
发帖数: 953 | 4 How safe does transgenic food need to be?
Laura DeFrancesco1
Journal name:
Nature Biotechnology
Volume:
31,
Pages:
794–802
Year published:
(2013)
DOI:
doi:10.1038/nbt.2686
Published online 10 September 2013 Corrected online 26 September 2013
Article tools
PDF
How safe does transgenic food need to be?
Download as PDF (812 KB) View interactive PDF in ReadCube
Citation
Reprints
Rights & permissions
Article metrics
Disputes over how to assess a foodstuff's safety continue to play into
public fears a... 阅读全帖 |
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s**p
发帖数: 275 | 5 【 以下文字转载自 Military 讨论区 】
发信人: stop (昵称), 信区: Military
标 题: 美科学杂志称：北京雾霾中含有1300种微生物
关键字: 北京雾霾
发信站: BBS 未名空间站 (Mon Feb 3 01:48:41 2014, 美东)
原标题：研究称北京雾霾含千种微生物会引发过敏和肺病
美国《大众科学》月刊称，一组中国研究人员检测了2013年1月北京空气样本DNA片段发
现，其中含有约1300种微生物。
大多数微生物无害，但有些会引发过敏和肺病。该研究小组发现，雾霾较重时危险微生
物浓度更高。
至于北京空气中的微生物真能让人生病还有待研究。
_gen/derivatives/landscape_630/1.14640-PA-15929780.jpg
2014年2月1日，发表在Scientific American 上题为“At Least Twice as Much DNA
of Pathogens and Allergens in Air on Beijing's Smoggiest Days” 的面向大众的
报道：
http://www.s... 阅读全帖 |
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B********e
发帖数: 19317 | 6 http://evolution.berkeley.edu/evolibrary/article/side_0_0/origsoflife_02
When did life originate?
Evidence suggests that life first evolved around 3.5 billion years ago. This
evidence takes the form of microfossils (fossils too small to be seen
without the aid of a microscope) and ancient rock structures in South Africa
and Australia called stromatolites. Stromatolites are produced by microbes
(mainly photosynthesizing cyanobacteria) that form thin microbial films
which trap mud; over time, laye |
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c**********d
发帖数: 389 | 7 我们活着为寄生体内的微生物服务！！
我们人体大概有10,000,000,000,000细胞。 可寄生体内的微生物有几十倍于此。 如果
我死了， 它们也都活不了了。
One way to think of it is that we live to feed the microbials living on us.
The average human body, consisting of about 10E13 (10,000,000,000,000 or
about ten trillion) cells, has about ten times that number of microorganisms
in the gut. There are many many more on the skin, vital organs etc.
If I do not live, all these living things die ;) |
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s*********t
发帖数: 4253 | 8 人类对科学不了解之处还很多呢。。。 你先破解以下十大科学不解之谜才自信的笑笑
人家弱智吧！
科学家连为何要睡觉都搞不清楚，你先把简单的给解决再来研究如何让太阳停留在空吧
。。
http://www.iflscience.com/physics/top-10-unsolved-mysteries-sci
（科学不解之谜）Why do we sleep?
While we do know that the human body is regulated by a circadian clock that
keeps humans on a sleep/wake cycle, we don’t really know why. Sleep is the
time when our bodies repair tissues and perform other maintenance activities
, and we spend nearly a third of our lives snoozing. Some other organisms
don’t need to sleep a... 阅读全帖 |
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s*********t
发帖数: 4253 | 9 上帝为何没公开显神迹没人知道
但如果就因为没显神迹而令你不相信他存在那也是大错特错。
因为很多现有的奇迹就在我们身边，
比如1）人类是从那里来的，
2）地心吸力由来
这些到今天科学家都无法解释。
Top 10 Unsolved Mysteries of Science
http://www.iflscience.com/physics/top-10-unsolved-mysteries-sci
How does gravity work?
We all know that gravity from the moon causes tides, Earth’s gravity holds
us to the surface, and the sun’s gravity keeps our planet in orbit, but how
much do we really understand it? This powerful force is generated from
matter, and more massive objects therefore have a greate... 阅读全帖 |
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B*******e
发帖数: 3882 | 10 “Toll-like receptors are a group of innate immune recognition molecules tha
t recognize the molecular patterns associated with microbial infections and
then induce immune response. Cells recognize viral infections by the presenc
e of double-stranded RNA, which is produced by most viruses during their rep
lication cycle. ” |
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z*h
发帖数: 773 | 11 Post our vision and advertisement -- innovative biomanufacturing.
Cell-Free Biosystems for Biomanufacturing
Although cell-free biosystems have been used as a tool for investigating
fundamental aspects of biological systems for more than 100 years, they are
becoming an emerging biomanufacturing platform in the production of low-
value biocommodities (e.g., H2, amylose, ethanol and isobutanol), fine
chemicals, and high-value protein and carbohydrate drugs and their
precursors. Here we would like t... 阅读全帖 |
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z*h
发帖数: 773 | 12 Post our vision and advertisement -- innovative biomanufacturing.
Cell-Free Biosystems for Biomanufacturing
Although cell-free biosystems have been used as a tool for investigating
fundamental aspects of biological systems for more than 100 years, they are
becoming an emerging biomanufacturing platform in the production of low-
value biocommodities (e.g., H2, amylose, ethanol and isobutanol), fine
chemicals, and high-value protein and carbohydrate drugs and their
precursors. Here we would like t... 阅读全帖 |
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z*h
发帖数: 773 | 13 Abstract
The global demand for food could double in another 40 y owing to growth in
the population and food consumption per capita. To meet the world’s future
food and sustainability needs for biofuels and renewable materials, the
production of starch-rich cereals and cellulose-rich bioenergy plants must
grow substantially while minimizing agriculture’s environmental footprint
and conserving biodiversity. Here we demonstrate one-pot enzymatic
conversion of pretreated biomass to starch through a ... 阅读全帖 |
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c*******n
发帖数: 1648 | 14 看到四个大字写在骑士的背上
勤奋求实！
我得到这真传的一半就可生存 达人们都是尽得真传！
microbial
means |
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q****0
发帖数: 282 | 15 from washington post
The scramble for government funding on the university level is a bare-
knuckle competitive business. Careers — and fortunes — are often tied
directly to getting the right grant at the right time.
One decorated researcher and professor from Virginia Tech is accused of
taking the government’s financial backing to an extreme.
Yiheng Percival Zhang, a professor at the school’s department of biological
systems engineering, was arrested last week, accused by federal authorities
of... 阅读全帖 |
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d********t
发帖数: 29 | 16 http://www.nasonline.org/site/PageServer?pagename=News_May_3_20
News
Date: May 3, 2011
FOR IMMEDIATE RELEASE
National Academy of Sciences
Members and Foreign Associates Elected
The National Academy of Sciences today announced the election of 72 new
members and 18 foreign associates from 15 countries in recognition of their
distinguished and continuing achievements in original research.
Those elected today bring the total number of active members to 2,113 and
the total number of foreign associat... 阅读全帖 |
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Z****Q
发帖数: 13 | 17 I graduated from zheda in 2002 with a master degree. Now i am at the end to
finish my ph.d study. My major is biochemical engineering, research field is
microbial fermentation and protein purification. If you know any available
opening in this area, could you please tell me or help me to distribute my
resume. Thanks a lot. I really appreciate your help. My contact information
is: cell (330)-990-1373. my e-mail: z***********[email protected]. |
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s******o
发帖数: 298 | 18 March 14, 2002 | Ever since it was trumpeted at a hastily convened press
conference in August 1996, the subject of possible signs of life in the Martian
meteorite ALH 84001 has remained intensely controversial. At the time, David
S. McKay (NASA/Johnson Space Center) and his coauthors presented four lines
of evidence suggesting that the 4-billion-year-old meteorite contains chemical
or fossil traces of microbial life. In the years since, however, these signs
have been disputed by other researcher |
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s******o
发帖数: 298 | 19 By David L. Chandler
Updated March 17, 2001 | All last week, attendees at the 33rd annual Lunar
and Planetary Science Conference in Houston, Texas, looked forward to one of
the meeting's final sessions, whose main attraction was the controversial 4
1/2-billion-year-old Martian meteorite known as ALH 84001. For years David S.
McKay (NASA/Johnson Space Center) and his coauthors have maintained that this
celebrated stone contains strong evidence — but not proof — of fossilized
microbial life.
Frida |
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s*****t
发帖数: 1994 | 20 Ancient Volcanos of Mars
Explanation: Findings of ancient martian microbial fossils in meteorites and liquid water
related features on Mars' surface are currently controversial issues. But one thing long
established by space-based observations of the Red Planet is the presence of volcanos, as Mars
supports some of the largest volcanos in the solar system. This synthetic color picture recorded
in March by the Mars Global Surveyor spacecraft shows two of them, Ceraunius Tholus
(leftmost) and Urani |
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d******f
发帖数: 14 | 21 Hi all,
Please help on the following two papers! If you happen to have the access,
could you please send it to my email: b********[email protected]
Methane production from municipal refuse: A review of enhancement techniques
and microbial dynamics
Morton A. Barlaz; Robert K. Ham; Daniel M. Schaefer; Ron Isaacson
Critical Reviews in Environmental Science and Technology, 1547-6537, Volume
19, Issue 6, 1990, Pages 557 – 584
Microorganisms in municipal solid waste and public health implications
Herber |
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s******y
发帖数: 28562 | 22 I believe such things are indeed available in the market.
You can google for it, or go to home depot(?) |
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p****n
发帖数: 9263 | 23 这玩意N年前就有国产的了，俺原先实验室还给做过鉴定，虽然质量比较差，但是来人
捏着李总理的小批
条，所以鉴定合格。 估计现在有比较成熟的产品了吧 |
|
m********n
发帖数: 953 | 24 遇到懂行的了， 先使劲谢谢一下啊
他们指定要美国生产的
我想请问一下啊，这个到底是就像一般土壤用的肥料， 还是培养细菌的培养基？ |
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m********n
发帖数: 953 | 25 我刚才google了一下，基本都是中国和印度的产品啊
难道美国不生产这个？ |
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p****n
发帖数: 9263 | 26 具体他们怎么做的不知道，最可能的是吧几个发酵池的产物混在泥巴里卖给你 |
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m********n
发帖数: 953 | 27 我刚google了一下
好像就中国和印度用这个很多，生产的公司也基本是两个国家的
美国不用这个？ 不生产这个？ |
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j*********n
发帖数: 168 | 28 呵呵，确实没什么稀奇，国内很早就有研究，加工生产。
你弟媳是要买了自己用，还是要做国内相关产品的代理，还是试图从人家的产品里分离
纯化菌种，自己生产呢？
一般大的超市都有花肥卖，你可以注意以下配方中，有没有添加这个，一般都是混在土
壤里用吧，还要根据栽培的植物种类进行调整。
作这样产品的代理，我劝你省省，没啥经济帐可算的。
分离菌种的话，更没必要买了产品再分离了啊。直接买菌种呗。不晓得哪个菌种好的话
，就委托在美的中国留学人员直接从类似产品里分呗，再把菌种弄回去不就行了么，哈
哈……好像有侵权的嫌疑，不过，微生物就这样了，细菌细胞上，可没有条形码和made
in USA的标注…… |
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|
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p****n
发帖数: 9263 | 31 hide in an Estee-Lauder cosmetics vial? |
|
|
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p*********g
发帖数: 9527 | 34 likely due to that US has strict regulations from EPA, USDA, and FDA. |
|
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b******n
发帖数: 4225 | 36 Gaskin DJH, Reuter M, Shearer N, Mulholland F, Pearson BM, van Vliet AHM:
Genomics of Thermophilic Campylobacter Species.
de Reuse H, Bereswill S (eds): Microbial Pathogenomics. Genome Dyn. Basel,
Karger, 2009, vol 6, pp 91–109
(DOI: 10.1159/000235765)
http://content.karger.com/produktedb/produkte.asp?doi=10.1159/000235765&typ=pdf
email: s****[email protected]
Thanks a lot! |
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B****m
发帖数: 63 | 37 Microbial Biosynthesis of Alkanes |
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s**********e
发帖数: 2888 | 38 你说的这个，其实就学术career(就是混碗饭吃）来说，也是非常不好的一条道路，也许做biofuel的会好一点，我就不知道了。
如果是做natural product biosynthesis，非常的不好。因为学术界的需求很少，到现在为止还都是纯粹的理论研究。所以出来的faculty都是那么几个大牛的学生，基本上如果你不是那么几个大牛，比如Christopher Walsh的学生，你几乎不可能在美国学术界找到位置。你看看最新的这个领域的faculty，几乎都是walsh的学生，老人不算。
我觉得原因是因为，这块的研究其实是几块的混合，genetics, biochemistry,
chemistry。最后的结果就是，你得genetics没有genetics的做得好，真正做genetics的人觉得你做的是小儿科；真正做biochemistry/chemistry的人也觉得你做得很简单。你牛的地方是这几块你都会做。
所以，纯粹的理论价值有限，应用前景不明了。其实说穿了，就是想和synthetic chemistry竞争。也许在遥远的未来，microbial biosynthesis会超过s |
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f**u
发帖数: 346 | 39 但问题是有些东西你不用生物合成不行。著名的紫杉醇就是一个例子。
我个人觉得如果你确定了一个天然产物有应用价值，但是没法化学合成，
那么去找biosynthetic pathway应该是应用前景很大的工作，当然难度是另一码事。
也许做biofuel的会好一点，我就不知道了。
现在为止还都是纯粹的理论研究。所以出来的faculty都是那么几个大牛的学生，基本
上如果你不是那么几个大牛，比如Christopher Walsh的学生，你几乎不可能在美国学
术界找到位置。你看看最新的
genetics的人觉得你做的是小儿科；真正做biochemistry/chemistry的人也觉得你做得
很简单。你牛的地方是这几块你都会做。
chemistry竞争。也许在遥远的未来，microbial biosynthesis会超过synthetic
chemistry，但是现在来看，synthetic chemistry还是非常的成熟强大稳定。 |
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k*****o
发帖数: 1486 | 40 J Antibiot (Tokyo). 2010 Jul 14. [Epub ahead of print]
Microbial paclitaxel: advances and perspectives.
最新taxol的微生物合成review，总结的非常好 |
|
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k*****o
发帖数: 1486 | 42 你讲的是经典microbial genetics，当然可以，大家都这么做过的。
housekeeping gene当然不能直接作，除非像二楼说的你清楚这gene是干什么的，然后
从培养基里补，比如说合成Lysine这种得essential gene，敲了就不能用minimal
medium了。
但是可以先转一个其他的去替换，方法实在多的数不过来，还是看你自己情况而定吧（
PS直接问你老板比在版上找块多了） |
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h**********r
发帖数: 671 | 43 Rebuilding microbial genomes, BioEssays 29:580–590, 2007 Wiley
Periodicals. |
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n***w
发帖数: 2405 | 44 Molecular and cellular mechanisms for microbial entry into the CNS.
pmid: 10602400
thank you.
Please send to n***[email protected] |
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a***a
发帖数: 40617 | 45 lol，谁来说说nasa是不是不要脸，我觉得很有喜感
G. Miller, and J. F. Stolz. 2005. A microbial arsenic cycle in a salt-
saturated, extreme environment: Searles Lake, California. Science. 308:1305-
1308. |
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g*********d
发帖数: 233 | 46 NASA不要脸!
L. G. Miller, and J. F. Stolz. 2005. A microbial arsenic cycle in a salt-
saturated, extreme environment: Searles Lake, California. Science.
308:1305-1308.
arsenic-metabolism-new-twists-on-an-old-poison |
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s****7
发帖数: 2507 | 47
L. G. Miller, and J. F. Stolz. 2005. A microbial arsenic cycle in a salt-
saturated, extreme environment: Searles Lake, California. Science.
308:1305-1308.
arsenic-metabolism-new-twists-on-an-old-poison
it is a different story. this paper is about a bacteria using As as energy
source. nasa's paper is using As in DNA. |
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O******e
发帖数: 4845 | 48 这下子微生物学领域要热闹一阵子了。
大家多讨论讨论现在这个“外星细菌”跟以往研究的相似和不同？
G. Miller, and J. F. Stolz. 2005. A microbial arsenic cycle in a salt-
saturated, extreme environment: Searles Lake, California. Science. 308:1305-
1308. |
|
z*h
发帖数: 773 | 49 Good findings.
G. Miller, and J. F. Stolz. 2005. A microbial arsenic cycle in a salt-
saturated, extreme environment: Searles Lake, California. Science. 308:1305-
1308. |
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c******n
发帖数: 5697 | 50 Arsenate也就是AsO4(3−)是phosphate analogue，也就是说对蛋白酶来讲，AsO4(3−)和PO4（3-）无区别，所以细菌的enzyme完全可以把它错当PO4（3-）使用，加入DNA和protein里，这个没有多大意义，你们还争论用不用分析化学鉴定，没意思
最主要的是As妨碍普通细胞的呼吸oxidative phosphorylation，普通细胞没法在As下生存，不可能繁殖
但是这种几年前就被发现了的细胞有酶可以中和As，还可以靠As呼吸， 所以可以靠As生长，所以在用As替换P的环境下繁殖，就丝毫不足为奇了
所以更有意义的发现不是As替代P， 而是细菌可以在As里繁殖。这是个老消息了，可怜NASA不要脸，又玩花样骗钱
早就说过了，NASA是个很可怜的机构，在资本主义社会中没有任何存在的意义，所以要向好莱坞学习，不停搞出新闻来，才可以吸引缴税人民的注意力，搞研究经费
http://www.microbemagazine.org/index.php/02-2010-home/1358-microbial-arsenic-metaboli... 阅读全帖 |
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