l*******r
发帖数: 407 | 1 http://blog.sciencenet.cn/home.php?mod=space&uid=2237&do=blog&i
摘要
1970年代早期，多数中国科学家，在文化大革命中努力生存而无机会开展研究。两位年
轻的研究者屠呦呦和张亭栋，分别在发现抗疟新药青蒿素和揭示砒霜化学成分三氧化二
砷对白血病的治疗作用的过程中起了关键作用。回顾四十年前开始的历程，不乏曲折和
反讽。青蒿素工作源于中国帮助越南抵抗美国，三氧化二砷源于观察、验证和改进乡村
中医的实践。虽然他们的药物挽救了世界上很多生命，两位研究者迄今未获国内外充分
肯定，屠呦呦有争议、张亭栋基本默默无闻。相关的文献埋没于冷僻的杂志和一般不易
看到的内部会议资料。基于原始中文论文、文件和采访，我们在此呈现这些发现的历史
概貌。没有逃脱我们的注意，在古代和近现代中文文献及医疗实践中，可能还有尚待重
新发现的珍宝。
引言
在中国使用了上千年的传统药物，能否改善现代人类的健康？在中国，有些人不认为这
是问题，而在中国以外的世界，中药并非现代人类普遍使用药物的主要来源。
对中药有两种截然相反的看法：在现代医学进展到今天后中药意义很小，甚至... 阅读全帖 |
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s*******h
发帖数: 3731 | 2 please ask KOJI NAKANISHI...
I
determine
spectrum |
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P****1
发帖数: 49 | 3 seems nobody realy know CD or ORD. |
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S******G
发帖数: 965 | 4 先把左边的lactone搞定就不用担心这个选择性了
不过这也不好搞。
物。 |
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R****n
发帖数: 708 | 6 http://www.pnas.org/content/108/8/3270.figures-only
This is a biochem paper. The supplementary material mentioned how to convert
a Glutamate Acid to 2-Hydroxygluataric acid. But no detailed infor
Quote from the paper
(R)-2-hydroxyglutarate Synthesis. (R)-2-hydroxyglutarate (2HG) was
synthesized by treatment of D-glutamate (Sigma-Aldrich) with nitrous
acid to forma lactone, which was then hydrolyzed with NaOH
solution to form 2-D-hydroxylglutarate. Purity was 93%. Powder
was resuspended in PBS an... 阅读全帖 |
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u**s
发帖数: 384 | 7 Title:Extraction, purification and identification of bacterial signal
molecules based on N-acyl homoserine lactones
Author: Jianhua Wang1,2,
Chunshan Quan3,*,
Xue Wang1,2,
Pengchao Zhao1,2,
Shengdi Fan3
Journal:Microbial Biotechnology
Special Issue: Thematic Issue on Extremophiles
Volume 4, Issue 4, pages 479–490, July 2011
Link:http://onlinelibrary.wiley.com/doi/10.1111/j.1751-7915.2010.00197.x/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+17+March+from+10-14+GMT... 阅读全帖 |
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j***j
发帖数: 560 | 11 Modified N-acyl-homoserine lactones as
chemical probes for the elucidation of plantmicrobe
interactions
Synthetic Communications, 25(6), 877-
82; 1995
By Guillerm, Danielle et al
Thanks in advance,
l***[email protected] |
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j***j
发帖数: 560 | 12 Facile Production Scale Synthesis of (S)-Taniguchi Lactone: A Precious
Building-Block
Org. Process Res. Dev., 2014, 18 (5), pp 643–645
Thanks in advance,
[email protected]/* */ |
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b****g
发帖数: 54 | 13 在做一个lactone的开环反应，只用了monomer和solvent，加催化剂
引发剂的话，应该是反应体系里没有除干净的水
我看到好多相关的paper，都说到反应一定分子量的时候
加过量的Chloroform去终止反应
为什么呢？ chloroform是怎么终止反应的？ 得到的polymer是如何封端的呢？
多谢？ |
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k***l
发帖数: 25 | 14 Planned to hydrolyze a PMMA-type polymer's side chain lactone to carboxylic
acid (or acid salt if in basic condition) and hydroxyl group.
Anybody has similar experience?
Thanks! |
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G*******s
发帖数: 92 | 15 Could someone help me for this article?
Ann N Y Acad Sci. 2000;922:164-74.
Modified lactone/carboxylate salt equilibria in vivo by liposomal delivery
of 9-nitro-camptothecin.
Chow DS, Gong L, Wolfe MD, Giovanella BC.
email: n***********[email protected]
Thanks! |
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m*********k
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m*********k
发帖数: 10521 | 17 "[Stock]
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m*********k
发帖数: 10521 | 18 "[Stock]bullpop Sep 11 ● 恭喜新斑竹上任！-跑跑发80个包子"
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M***n
发帖数: 5815 | 19 注：1）版面活动：手续费无；个人申请：手续费10%；:
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Stock
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【有奖竞猜】明天周三S&P500指数收盘点位
http://www.mitbbs.com/article_t/Stock/36364801.html
赞助（有：附链接。没有：无）::
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备注::
谢谢一夫！辛苦了！对你的工作表示诚挚感谢！ |
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m*********k
发帖数: 10521 | 20 "[Stock]MrRun Sep 15 ● 【有奖竞猜】明天周三S&P500指数收盘点位"
扣除版面:(Stock)100伪币成功
成功奖励 50 伪币的用户:?Xman0000
成功奖励 30 伪币的用户:?Crocodile1
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m*********k
发帖数: 10521 | 23 "[Stock]MrRun Dec 24 ● 股版11月水枪奖"
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m*********k
发帖数: 10521 | 24 "[Stock]NYKnicks May 31. ● 5月古板水枪包"
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N******s
发帖数: 10555 | 25 注：1）版面活动：手续费无；个人申请：手续费10%；:
1)
代发版面/ID::
stock版
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2016年6月水枪奖励
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以下ID前20每人奖励100伪币，后30名每人奖励80伪币
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m*********k
发帖数: 10521 | 26 "[Stock]NYKnicks Jun 29 ● 6月水枪"
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m*********k
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m*********k
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