v*******e
发帖数: 11604 | 1 先申明一下，我不是业界大牛，只是因为感兴趣所以读了不少这个方面的文章。所以我
说的话都不一定是对的。
看了一批文章，总结这个故事最make sense。修改下不准确的地方。加reference。
细胞在G2的时候，由于各种因素造成DNA损坏（过氧化，辐射，端粒太短，某些致癌基
因表达导致SSB或者DSB等），引起P53表达，P53表达引起P21表达，P21的水平高到一定
程度就会把cyclin B1关进细胞核不出来【Krenning 2014】，加上其他P21影响的其他
途径（cdk1（次要）, RB（比前者重要）， 等）导致细胞跳过M，直接进入G1【Ye
2013, Johmura 2014】或者某些别的致癌基因表达，虽然没有DNA损坏，但是只要引起
DDR，也可以导致细胞跳过M，直接进入G1。或者，强制引起P53表达，或者强制P21表达
，或者什么别的原因导致细胞跳过M，直接进入G1
【Krenning 2014, Johmura 2014, Sussman 2014】。这样的细胞是4倍体，如果继续细
胞周期则会先8倍体然后分裂；因为多个centrosome或者其他原因会导致细胞染... 阅读全帖 |
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n*********m
发帖数: 38 | 2 Immunology Retraction Exposes Misconduct
07/10/2013 Andrew S. Wiecek
Nature retracts a 1994 paper after the first author was found to have "most
likely" committed research misconduct. Learn more...
Last week, Nature retracted a highly-cited paper published in 1994 because
the authors were unable to reproduce the results, according to the
retraction notice (1). But the real reason behind the retraction might have
more to do with the first author’s scientific misconduct.
Nature has retracted a 19... 阅读全帖 |
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n*********m
发帖数: 38 | 3 mmunology Retraction Exposes Misconduct
07/10/2013
Andrew S. Wiecek
Nature retracts a 1994 paper after the first author was found to have "most
likely" committed research misconduct. Learn more...
Last week, Nature retracted a highly-cited paper published in 1994 because
the authors were unable to reproduce the results, according to the
retraction notice (1). But the real reason behind the retraction might have
more to do with the first author’s scientific misconduct.
Nature has retracted a 199... 阅读全帖 |
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d***a
发帖数: 316 | 4 没什么可怕的，对于需要器官移植的人来说，是梦寐以求的。
Nature Medecine. 2008 Feb;14(2):213-21. Epub 2008 Jan 13.
Perfusion-decellularized matrix: using nature's platform to engineer a
bioartificial heart.
Ott HC, Matthiesen TS, Goh SK, Black LD, Kren SM, Netoff TI, Taylor DA.
Department of Surgery, Massachusetts General Hospital, Harvard Medical
School, 55 Fruit Street, Boston, Massachusetts 02114, USA.
Abstract
About 3,000 individuals in the United States are awaiting a donor heart;
worldwide, 22 million individuals are ... 阅读全帖 |
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N****f
发帖数: 25759 | 5 讲座结束，现在进行随堂小测验。哪位知道这是李太白
笔下那个名句？
mieng ngyat chiyt then sren,
chang mang yon haix kren.
Anir一定知道答案，可惜她戒网了，呵呵。 |
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