u*********1
发帖数: 2518 | 1 我做ALS-FTD相关的，所以先从C9orf72说起；C9orf72里的repeat expansion都发现两
年了，但好像到现在我们不仅搞不清楚repeat expansion到底是如何作用的（除了那个
可能的non ATG translation），也搞不清楚C9orf72到底是什么功能。。。所以还是在
用C9orf72这么ugly的名字。不知道有没有什么搞C9的内行人士来说说。。
还有一个长期困扰我的八卦问题。2011年neuron上最早报道C9orf72 expansion的两篇
文章。。。我觉得这么重大重大的发现足以发science nature，为何会只发在neuron上
？难道是两个组当时在竞争？或者有什么别的内幕？
再推广到整个的neurology；很多很多neurological disorder都是repeat expansion导
致的；repeat expansion听起来很fancy，平白无故的增多了1000个repeat，别说
coding region或者promoter了，哪怕在intron区域我们也会很“自信”的认为比如会
影响splicing等等。... 阅读全帖 |
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S*******h
发帖数: 7021 | 5 【 以下文字转载自 USANews 讨论区 】
发信人: ddsd (ddsd), 信区: USANews
标 题: California lost 9000 Bussinesses, HQ, and expansions over
发信站: BBS 未名空间站 (Sun May 28 20:05:21 2017, 美东)
California lost 9000 Bussinesses, HQ, and expansions over the last 8 years,
many moved to Texas...
Roughly 9,000 California companies moved their headquarters or diverted
projects to out-of-state locations in the last seven years, and Dallas-Fort
Worth has been a prime beneficiary of the Golden State’s “hostile”
business environment.
... 阅读全帖 |
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S*******h
发帖数: 7021 | 6 【 以下文字转载自 USANews 讨论区 】
发信人: ddsd (ddsd), 信区: USANews
标 题: California lost 9000 Bussinesses, HQ, and expansions over
发信站: BBS 未名空间站 (Sun May 28 20:05:21 2017, 美东)
California lost 9000 Bussinesses, HQ, and expansions over the last 8 years,
many moved to Texas...
Roughly 9,000 California companies moved their headquarters or diverted
projects to out-of-state locations in the last seven years, and Dallas-Fort
Worth has been a prime beneficiary of the Golden State’s “hostile”
business environment.
... 阅读全帖 |
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S*******h
发帖数: 7021 | 7 【 以下文字转载自 USANews 讨论区 】
发信人: ddsd (ddsd), 信区: USANews
标 题: California lost 9000 Bussinesses, HQ, and expansions over
发信站: BBS 未名空间站 (Sun May 28 20:05:21 2017, 美东)
California lost 9000 Bussinesses, HQ, and expansions over the last 8 years,
many moved to Texas...
Roughly 9,000 California companies moved their headquarters or diverted
projects to out-of-state locations in the last seven years, and Dallas-Fort
Worth has been a prime beneficiary of the Golden State’s “hostile”
business environment.
... 阅读全帖 |
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S*******h
发帖数: 7021 | 8 【 以下文字转载自 USANews 讨论区 】
发信人: ddsd (ddsd), 信区: USANews
标 题: California lost 9000 Bussinesses, HQ, and expansions over
发信站: BBS 未名空间站 (Sun May 28 20:05:21 2017, 美东)
California lost 9000 Bussinesses, HQ, and expansions over the last 8 years,
many moved to Texas...
Roughly 9,000 California companies moved their headquarters or diverted
projects to out-of-state locations in the last seven years, and Dallas-Fort
Worth has been a prime beneficiary of the Golden State’s “hostile”
business environment.
... 阅读全帖 |
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A******y
发帖数: 2041 | 9 Google Friedreich's ataxia. The repeat expansion is in the first intron.
The transcription factor falls off. If you have 50% of mRNA, you are fine (
carriers). However, if you have two expansions, you are screwed. If we
cannot cure this, we can cure any genetic disease considering the gene is
normal. Huntington's disease is also a repeat expansion, but even the mRNA
with expansion is toxic.
在 university1 (guang) 的大作中提到: 】 |
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发帖数: 1 | 12 California lost 9000 Bussinesses, HQ, and expansions over the last 8 years,
many moved to Texas...
Roughly 9,000 California companies moved their headquarters or diverted
projects to out-of-state locations in the last seven years, and Dallas-Fort
Worth has been a prime beneficiary of the Golden State’s “hostile”
business environment.
That’s the conclusion of study by Joseph Vranich, a site selection
consultant and president of Irvine, California-based Spectrum Location
Solutions.
Of the 9,000 bu... 阅读全帖 |
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j*****e
发帖数: 11116 | 13 广告标题:
求东部Seagate Expansion 1TB
我现有的物品:
Seagate Expansion 1TB@CA
我想要的物品:
Seagate Expansion 1TB@NY or 东部
建议交换比率 (required):
1：1 卖给我也可以
邮寄方式要求:
ML
买卖双方谁承担邮寄损失(required if not code only):
其它补充说明:
广告的有效期:
1 day
我的联系方式:
单张面值:
物品来源 (required for ALL cards!):
staples |
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c**p
发帖数: 1443 | 14 【 以下文字转载自 Pharmaceutical 讨论区 】
发信人: GeorgeCobain (铁丝钢琴手), 信区: Pharmaceutical
标 题: Pfizer set for big Chesterfield expansion
发信站: BBS 未名空间站 (Wed Aug 22 10:25:23 2007)
Pfizer set for big Chesterfield expansion
By Rachel Melcer
ST. LOUIS POST-DISPATCH
08/22/2007
Pfizer Inc. is breaking ground today on a $50 million expansion in
Chesterfield that signals the increasing importance of biotech drugs to the
struggling pharmaceutical giant.
The company, based in New York, is doubling the size of a pilot |
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发帖数: 1 | 15 California lost 9000 Bussinesses, HQ, and expansions over the last 8 years,
many moved to Texas...
Roughly 9,000 California companies moved their headquarters or diverted
projects to out-of-state locations in the last seven years, and Dallas-Fort
Worth has been a prime beneficiary of the Golden State’s “hostile”
business environment.
That’s the conclusion of study by Joseph Vranich, a site selection
consultant and president of Irvine, California-based Spectrum Location
Solutions.
Of the 9,000 bu... 阅读全帖 |
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l******n
发帖数: 47 | 16 http://www.weidb.com/p11174
With the current dump size and height, the wind blows the odor to everywhere
in Milpitas, some of North San Jose, Santa Clara, and South Fremont; with
the increased volume and height, the wind can blow much farther and reach
downtown San Jose, the place where city government officials work and
residents live. Commissioners, please save us, our kids, including you, the
dump expansion permit decision makers, from the noxious odor and vote No on
the expansion permit.
Ple... 阅读全帖 |
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发帖数: 1 | 17 California lost 9000 Bussinesses, HQ, and expansions over the last 8 years,
many moved to Texas...
Roughly 9,000 California companies moved their headquarters or diverted
projects to out-of-state locations in the last seven years, and Dallas-Fort
Worth has been a prime beneficiary of the Golden State’s “hostile”
business environment.
That’s the conclusion of study by Joseph Vranich, a site selection
consultant and president of Irvine, California-based Spectrum Location
Solutions.
Of the 9,000 bu... 阅读全帖 |
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A**r
发帖数: 43 | 18 除了repeat expansion之外，CNV也高频率的出现在ASD之类的neurological disorder
里面，不知道为什么。这些可能都是neurological disorder的特殊之处。
会不会是由于，神经系统之外的基因出现了repeat expansion，可能没啥显著
phenotype，或者直接致死？神经系统面对基因表达的变化，可能会出现不致死但是很
明显的phenotype。
repeat expansion对于人类大脑的进化，会不会有什么特殊意义？或者C9orf72是不是
本身进化就比较快？ |
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L*******t
发帖数: 2385 | 19 Expansion方法的通病是Expansion阶数变高的时候，Expansion Terms数量的增长往往
是几何级数的。
大家有没有什么好办法解决这个问题呢？ |
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g****r
发帖数: 4 | 20 我觉得你和楼主讨论的不是同个东西（虽然有联系）。你说的是regression 和make
love里面的model用什么basis，你可以采取regularization 减小某个basis 上的参数
。 楼主说的是PDE的expansion 方法，例如asymptotic expansion 和 WKB expansion.
不过我猜两者应该是有联系的，例如galerkin。我也是刚刚接触 |
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l****z
发帖数: 29846 | 25
By DICK MORRIS & EILEEN MCGANN
Published on DickMorris.com on January 7, 2011
Every Republican member of Congress should sign the following pledge, being
promulgated by Grover Norquist's Americans for Tax Reform:
"I promise not to vote for any expansion of the federal debt limit unless it
is preceded or accompanied by significant cuts in federal spending."
We all know that the reason the federal government debt is exploding is the
reckless spending policies of the Obama Administratio... 阅读全帖 |
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a****n
发帖数: 1119 | 26 [收购/求购] wow lich king expansion $25起
为了配合frys 25周年店庆，决定与西海岸各州的护士进行交流合作。
今天部分得到消息的护士已经high了一天，明天是周末，希望护士们再接再厉，把扫货
行动推向高潮
对于不认识我的护士，我的feedback可以查看fleamarket feedback汇总
我想要的物品:
wow wrath of the lich king expansion set from Frys local store
frys item number 5730432
http://www.frys.com/product/5730432
单张面值:
$19.80 + tax
物品要求
现货
包装封口必须完好，封口被拆开的不要
数量要求
不限量
可接受的价格(必须明码标价！):
为了激励护士的热情和效率，采用累进价格
一个transaction中
1 - 20个 $25.00/each
21 - 99个 $26.00/each
如果超过100个，请pm我询价
邮寄方式要求:
待定，运费我出
买卖双方谁承担邮寄损失(Required if |
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c*u
发帖数: 916 | 27 今天去heating supply抱回来一个expansion tank，一个venting valve，卖东西的人
要我顺便把pressure check valve也买了，一共花了将近70元。减压阀不知道为什么和
back-flow preventor竟然是搭配卖的，不分开卖，共60多元，所以暂时就没买。店小
二给我一个warning，说搞好后要purge system，不知道怎么搞大冬天最好不要动，或
者请plumber，是这样的么？
回家果然那个expansion tank转不下来了，好像是彻底绣死了，上了WD 40也没用，如
果锯掉重新焊需要什么设备？我看Home depot卖的propane torch好像只能用来焊小管
子，1 inch粗的管子能弄么？ |
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V****o
发帖数: 210 | 28 要expansion tank，水加热后会膨胀的，没有expansion tank会导致阀门出水的。 |
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M*********l
发帖数: 214 | 29 那个boiler expansion tank 是Fill-Trol 牌子的， boiler是用来加热water heater
的，进几年运行启动时候听到很大的噪音。 最近两周特别冷，发现expansion tank在
boiler启动时候会漏点像油一样的东西， 能自己修吗？ 需要找boiler specialist吗？
推迟修会坏掉吗？ 管道里面不知道是油还是水？ 漏出来的摸起来像油。 |
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s******e
发帖数: 1985 | 30 Accelerated timetable for Big Ten expansion
April 17, 2010 3:24 PM | 29 Comments
By Teddy Greenstein
Remember the talk that the Big Ten would take 12-18 months to decide whether
to expand?
An accelerated timetable has emerged, according to sources familiar with the
process.
High-ranking Big Ten representatives will meet Sunday afternoon in
Washington D.C. to discuss expansion. The timing and location of the session
make sense considering the Association of American Universities is holding
its se |
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B***L
发帖数: 1923 | 31 BIRMINGHAM, Ala. -- The Southeastern Conference isn't ready to expand yet.
SEC leaders met Monday for their regularly scheduled fall meeting but took
no action on expansion.
The SEC says in a statement that the presidents and chancellors "discussed a
wide range of issues dealing with the changing landscape of intercollegiate
athletics" but didn't make any moves on expansion.
The SEC is adding a 13th member when Texas A&M joins the league in July.
University of Missouri curators have given chance... 阅读全帖 |
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y*********n
发帖数: 1059 | 32 发信人: stallion (Kendall/43619*), 信区: History
标 题: 西藏简史2004：Ch 3. Expansion of Tibet
发信站: Unknown Space - 未名空间 (Mon Dec 6 02:27:14 2004) WWW-POST
3. Expansion of Tibet
Conflicts broke out when Tibetan Kingdom forced one of Tang’s protectorates,
Palür, to convert to Tibet and built a fortress between Palür and Tang.
This fortress blocked score of other nations of their route to China. All of
them submitted to Tibet subsequently.
To revenge and to resume the silk-road that had been severed, Tang Emp |
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A**r
发帖数: 43 | 33 repeat expansion的机制可能是多方面的吧？
不仅仅会影响transcription，splicing，也可能影响translation。
总之大概是影响expression level？
比如导致Fragile X Syndrome的FMR1基因，在5’UTR有CGG repeat expansion，结果是
FMRP mRNA增加，但FMRP protein减少。
临床治疗的话可能要根据这个蛋白的具体功能吧？恢复C9orf72的正常表达，或者直接
target下游pathway？
比如在Fragile X syndrome里面，FMRP表达降低。由于FMRP本身抑制mGluR5-dependent
protein synthesis，去抑制导致mGluR5-dependent protein synthesis过高。于是在
FMRP的小鼠模型里面，用mGluR5 antagonist就可以reverse小鼠的behavior phenotype。 |
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G**********n
发帖数: 973 | 34 Pfizer set for big Chesterfield expansion
By Rachel Melcer
ST. LOUIS POST-DISPATCH
08/22/2007
Pfizer Inc. is breaking ground today on a $50 million expansion in
Chesterfield that signals the increasing importance of biotech drugs to the
struggling pharmaceutical giant.
The company, based in New York, is doubling the size of a pilot plant that
produces protein-based, injectible biologic drugs for clinical trials. All
of the biologics developed by Pfizer globally will pass through the facility.
Th |
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h*****t
发帖数: 1226 | 35 Genzyme to begin $150m expansion of Allston plant
Facility to boost capacity and jobs
By Todd Wallack, Globe Staff | September 15, 2007
Genzyme Corp., the Cambridge biotechnology giant, is planning a ground-
breaking ceremony Tuesday morning for a $150 million expansion of its
Allston manufacturing plant along the Charles River.
A Genzyme spokesman said the work is expected to take two years and will
boost the size of the building by nearly two-thirds, to 300,000 square feet.
The additional sp |
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w*******y
发帖数: 60932 | 36 Amazon is selling the Fisher-Price Thomas the Train: Deluxe Expansion Track
Pack for $8.49. You can pre-order now and it will ship out on Jan 5'th 2011.
The same sells for around $16 at walmart..
Fisher-Price Thomas the Train: Deluxe Expansion Track Pack
1 Switch Track (Right)
1 Switch Track (Left)
2 Ascending Curved Tracks (Right)
2 Ascending Curved Tracks (Left)
2 Level 1 Rail Girders
2 Level 2 Rail Girders
4 Half Straight Tracks
8 Straight Tracks
10 Curved Tracks
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w*******y
发帖数: 60932 | 39 Sins of a Solar Empire - Trinity
This new bundle pack includes the original Sins of a Solar Empire, plus the
Entrenchment and Diplomacy expansions.
Link:
http://www.impulsedriven.com/sinstrinity
This is the cheapest they've sold all three combined. The last Sins of a
Solar Empire sale was $4 for the original game and the last time they had
the expansions for sale they were $15 for both.
Another game of note, is Sword of the Stars Complete:
http://www.impulsedriven.com/sotscomcol
for $5.99 ($2... 阅读全帖 |
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w*******y
发帖数: 60932 | 42 Seagate - Expansion 500GB External USB 2.0 Hard Drive - Black
Model: ST305004EXA| SKU: 9609412
Sale:$ 29.99 Reg. Price:$69.99
Link:
http://www.bestbuy.com/site/Seagate - Expansion 500GB External USB 2.0 Hard Drive - Black/9609412.p?skuId=9609412&productCategoryId=pcmcat186100050005&id=1218130485136
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w*******y
发帖数: 60932 | 43 For those of you who have jumped on the Dominion deals in the past few weeks
, this is a great expansion for the game. Usually retails for about $30, on
sale for $21.99 for a limited time.
Sale expires after 4 hours or they run out of stock.
Dominion Seaside Expansion:
http://www.amazon.com/gp/product/B002THXRWK
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w*******y
发帖数: 60932 | 45 7 Wonders: Leaders
List Price: $29.99
Price: $14.99
You Save: $15.00 (50%)
In Stock.
Ships from and sold by Amazon.com. Gift-wrap available.
Link:
http://www.amazon.com/Asmodee-SEVUS02ASM-7-Wonders-Leaders/dp/B
For those like me who got in on the FP 7 Wonders core game set, I just
picked up this expansion as it just hit an all time low.
Great expansion as it adds more replayability along with a welcomed
strategic/random element to an already fun game.
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j**y
发帖数: 7014 | 46 zt
Tuesday turned out to be a good night for Notre Dame on avoiding the chaos o
f conference expansion in the NCAA.
The Pac-12 Conference announced late Tuesday it will not expand beyond 12 te
ams, meaning the Big 12 should stay intact for now. There was strong specula
tion that Texas, Texas Tech, Oklahoma and Oklahoma State would consider bolt
ing to form the Pac-16.Meanwhile, the remaining Big East football members me
t Tuesday night in New York City and the league says everyone is committed t... 阅读全帖 |
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发帖数: 1 | 47 Gov. Newsom DEMANDING $260 MILLION for Medicaid Expansion to Illegal
Immigrants
http://twitter.com/GavinNewsom/status/1083153698161917952
Healthcare should be a basic human right. Republicans in DC are already
attacking our efforts to provide quality, affordable healthcare to everyone
who calls CA home. We cannot accept the status quo. We must keep demanding
better care for ALL Californians.
没钱看病call CA home就好了, 给加州点个赞，加州加油 |
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发帖数: 1 | 48 因为气压表最低20，原装是15测不出来。
现在终于测出来了。
大家家里的expansion tank都是什么读数？高一点没问题吧？
知道的说说 |
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