s********e
发帖数: 1596 | 1
你是说晓东的工作没有开创性？如果当年C.elegans 没有的诺贝尔奖的话，晓东得奖的
希望还是很大滴。 |
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f****y
发帖数: 104 | 2 Looks it is related to longevity in worm. See this paper:
A systematic RNAi screen identifies a critical role for mitochondria in C.
elegans longevity.
Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G.
Nat Genet. 2003 Jan;33(1):40-8. Epub 2002 Nov 25.
A classical genetic screen identified a mutation in the mitochondrial leucyl
-tRNA synthetase gene (lrs-2) that impaired mitochondrial function and was
associated with longer-lifespan. |
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c********r
发帖数: 1125 | 3 Cong~! I think oliver is a great scientist in the neuron-c.elegans fields,
and it's amazing that you got interview after a phd in China.You must have
fairly good background.
It's normal to let the candidate have on-campus interview, the question is
whether he will pay for your travel expense~
he is going to give lecture on one of my course tomorrow, maybe I can tell
you more about him tomorrow.. |
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g*********d
发帖数: 233 | 4 The role of small non-coding RNAs in genome stability and chromatin
organization
http://jcs.biologists.org/content/123/11/1825.full
Josien C. van Wolfswinkel and René F. Ketting*
Journal of Cell Science 123, 1825-1839
© 2010. Published by The Company of Biologists Ltd
doi:10.1242/jcs.061713
Summary
Small non-coding RNAs make up much of the RNA content of a cell and have
the potential to regulate gene expression on many different levels.
Initial discoveries in the 1990s and early 21st centur... 阅读全帖 |
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g*********d
发帖数: 233 | 5 《Cell》文献翻译:基因表达的小RNA调节因子
Cell 134, 899 – 902, September 19, 2008
Joel R. Neilson and Philip A. Sharp
今年Lasker基金会承认了Victor Ambros、Gary Ruvkun和David Baulcombe在推断
小RNA分子在真核基因表达的转录后调节中所进行的开创性工作。
分子生物学是一门年轻的学科，如同充满了未开发土地的新大陆。有关小RNA在基
因调节中的作用的重要发现是这门年轻学科中还有许多未开发的重要领域的一个例证。
9月26日，几位先驱（麻州大学医学院的Victor Ambros、麻州总医院和哈佛大学医学院
的Gary Ruvkun和剑桥大学的David Bulcombe有关小RNA的发现将被授予2008年Albert
Lasker基础医学研究奖。
历史上先驱者以及他们的发现的意义通常被忽略，只是在很多年之后才被承认。
Ambros和Ruvkun所发表的描述第一个微RNA及其标靶的优秀论文（发表在高深的Cell杂
志上）被忽略了近10年。与此同时，... 阅读全帖 |
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g*********d
发帖数: 233 | 6 RNA干扰及其在动物繁殖中的应用
2009-12-28
RNA 干扰(RNA interference, RNAi)是生物进化过程中遗留下来的一种在转录后通
过 RNA 调控基因表达的机制, 它是指在真核细胞中引入双链 RNA分子从而导致具有序
列同源性的基因产生特异性基因沉默 (gene silencing)的现象 。由于 RNA干扰可以阻
断特定的基因表达, 具有超越疫苗和抗病毒药物的诸多优点, 因此在阐述基因功能以及
蛋白质相互作用等方面, 表现出诱人的前景。近年来随着分子生物学的发展, RNAi 的
机制也不断被阐明, 同时国内外研究也证实 RNAi 技术可以为动物繁殖过程中所涉及的
基因功能提供一条新的思路, 这在科研和生产实践上都具有重要的意义。
1 RNAi的发现
Matzke 等于 1989 年报道了启动子介导的序列同源性基因共转染烟草可引起转
基因表达发生沉默。 1990 年, Napoli 和 Van der Krol 等为了让矮牵牛花的颜色更
加鲜艳, 把与紫色相关的查尔酮(chalcone)基因转染到牵牛花内, 结果意外发现, 植物
体的颜色... 阅读全帖 |
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k*****n
发帖数: 417 | 7 Their top5 highly cited research papers:
Wei Gu:
Title: Negative control of p53 by Sir2 alpha promotes cell survival under
stress
Times Cited: 822 (from Web of Science)
Title: Deacetylation of p53 modulates its effect on cell growth and
apoptosis
Times Cited: 331 (from Web of Science)
Title: Deubiquitination of p53 by HAUSP is an important pathway for p53
stabilization
Times Cited: 319 (from Web of Science)
Title: Mono-versus polyubiquitination: Differential control of p53 fate by
Mdm2
Times Ci... 阅读全帖 |
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c********r
发帖数: 1125 | 8
不止一篇pnas,一篇cell metabolism。。。
Zhou KM; Dong YM; Ge Q ... Xu T, PKA activation bypasses the requirement for
UNC-31 in the docking of dense core vesicles from C.elegans neurons, Neuron
, 2007, 56: 657-669.
Bai L, Wang Y, Fan JM... Xu T. Dissecting multiple steps of GLUT4
trafficking and identifying the sites of insulin action. Cell Metabolism.
2007, 5:47-57.
Kang LJ, He ZX, Xu PY, Fan J, Betz A, Brose N, Xu T. Munc13-1 is required
for the sustained release of insulin from pancreatic beta cells. C... 阅读全帖 |
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p*******r
发帖数: 4048 | 10
都有。 反正就是离共同祖先挺远， 比如C elegans, 果蝇这些，其实离共同祖先挺远
的，和人类的很多相似也许都是convergent evolution. |
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c********r
发帖数: 1125 | 11 这个不算啥啊。。。很多cns文章修改要1年以上。。check this out:
1.Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51
filament formation
Nature 479, 245–248 (10 November 2011) doi:10.1038/nature10522
Received 25 September 2009 Accepted 30 August 2011 Published online 23
October 2011
修改了差不多2年。。。
2.Protons Act as a Transmitter for Muscle Contraction in C. elegans
Received: November 21, 2005 Revised: July 7, 2007 Accepted: October 25, 2007
Published: January 10, 2008
也修改了将近2年。。 |
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L*******e
发帖数: 2153 | 12 For a long time starvation/calories restriction has been considered as one
prominent way to slow down aging or increase longevity. : )
Increasing expression of sirtuin proteins has been indicated to extend
lifespan on models such as C. Elegans and Drosophila melanogaster.
However, lately there are some controversies on the effects of sir2 gene on
longevity . Some people question the genetic back-crossing artifacts on
those transgentic models maybe the direct cause of sirtuin's protective
effec... 阅读全帖 |
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a**m
发帖数: 184 | 13 Age-associated changes in expression of small, noncoding RNAs, including
microRNAs, in C. elegans.
麻烦大侠发到y********[email protected]
谢谢！ |
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M**a
发帖数: 4816 | 14 26 January, 2012 Volume 1, Issue 1EditorialMore than the Sum of Its Parts p1
Boyana Konforti
Full Text | PDF (62 kb)
More than the Sum of Its Parts
Boyana Konforti
Editor, Cell Reports
Welcome to the first issue of Cell Reports, a new open-access journal that
covers all of biology with a focus on high-quality short papers. There are,
of course, other open-access journals—in fact, quite a number have launched
just in recent years (and there will almost certainly be more to follow)—
though few hav... 阅读全帖 |
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M**a
发帖数: 4816 | 15 26 January, 2012 Volume 1, Issue 1EditorialMore than the Sum of Its Parts p1
Boyana Konforti
Full Text | PDF (62 kb)
More than the Sum of Its Parts
Boyana Konforti
Editor, Cell Reports
Welcome to the first issue of Cell Reports, a new open-access journal that
covers all of biology with a focus on high-quality short papers. There are,
of course, other open-access journals—in fact, quite a number have launched
just in recent years (and there will almost certainly be more to follow)—
though few hav... 阅读全帖 |
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l**********1
发帖数: 5204 | 16 Y-2-H 用多重标记 做对照和比较
比如以下的 split-luciferase+GST+HA-epitope tagged
三重标记
they found new proteins interaction paper:
//www.ncbi.nlm.nih.gov/pubmed/21530591
Protocol details:
>the wheat germ in vitro translation system for use in the splitlu
ciferase
assay and co-purifications with glutathione S transferase
(GST)- and HA-epitope tagged proteins (Fig. 2A).
>
In the split-luciferase assay, proteins of interest are fused to
N- and C-terminal fragments of luciferase. If the proteins interact,
the N... 阅读全帖 |
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l**********1
发帖数: 5204 | 17 rna-seq
知道是啥吗
不清楚的话 维基一下吧
//en.wikipedia.org/wiki/RNA-Seq
RNA-seq, also called "Whole Transcriptome Shotgun Sequencing" [1] ("WTSS")
and dubbed "a revolutionary tool for transcriptomics",[2] refers to the use
of high-throughput sequencing technologies to sequence cDNA in order to get
information about a sample's RNA content, a technique that is quickly
becoming invaluable in the study of diseases like cancer.[3] Thanks to the
deep coverage and base level resolution provided by next-generation
s... 阅读全帖 |
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p*****e
发帖数: 332 | 18 我听说C elegan是这么回事，
Vetebrate应该还是太复杂了 |
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l**********1
发帖数: 5204 | 20 LZ if can think relocation to another State/City
please go to
//evol.mcmaster.ca/~brian/evoldir/Jobs/UKansas.ResTech.DrosophilaEvol
you can meet
>
An NIH-funded Research Technician position is available in Stuart Macdonald'
s lab in the Department of Molecular Biosciences at the University of Kansas
ignored
Required qualifications are a Bachelors degree in biology or a related field
, and lab experience with a (broadly-defined) "model" genetic system such as
Drosophila, C. elegans, mouse, Arabid... 阅读全帖 |
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l**********1
发帖数: 5204 | 21 Please keep in mind that original post
> 最初论文(publishe 50Y ago possible)
可能的时间跨度指1962-2011
any year is possible.
从最初投稿到accepted for publish
Cell 需时间 比N/S 长3～4倍
2006 Nobel winner
RNAi father: AZ Fire
//en.wikipedia.org/wiki/Andrew_Fire
RNAi within nematode
//www.ncbi.nlm.nih.gov/pubmed/10535731
over 13 month
N
//www.ncbi.nlm.nih.gov/pubmed/9486653
S
//www.ncbi.nlm.nih.gov/pubmed/1314423
both 4～5 month
不要说AZ Fire 以前没Cell 啊 至少有两篇
Cell. 1981 (3 Pt 2):555-61.
Inhibition of transcription factor ac... 阅读全帖 |
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g*****n
发帖数: 241 | 22 据说线虫领域以前是这样的，比如去年Cynthia Kenyon的一篇回忆体的综述里面是这么
写的“By this time, I was chomping at the bit to study ageing myself. I
decided not to work on age-1 for two reasons. First, in our friendly C.
elegans culture, it was not polite to study someone else's gene, and age-1
belonged to Tom. But mainly, I wanted to carry out my own screen for long-
lived mutants, to see what came out. ”
不过现在竞争也激烈了 |
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a*****x
发帖数: 901 | 24 科研感兴趣的是1000个signel cell的关系，所以是从线虫的表型观察1000个single
cell,从不是从1000个single cell去模拟或者推导C elegans. |
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w***7
发帖数: 1637 | 25 source：http://bbs.netbig.com/thread-2491712-1-2.html
看了一下，今年不错啊，和清华并驾齐驱。
而且下半年我知道的还有两篇NS。
~~~~~~~~~~~~~~~~~
1.
Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z,
Chai J, Zhou XJ, Gao S, Zhu B
Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3
Lysine 27 Methylation
Science, DOI: 10.1126/science.1225237, Aug. 24, 2012
2.
Liu B, Du H, Rutkowski R, Gartner A, Wang X
LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino
Acid Homeostasis
S... 阅读全帖 |
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c********r
发帖数: 1125 | 27 第一题：
如果室温24左右的话，L1虫子2天过后基本就是刚young adult,开始产卵但不是很多得
水平，孵化出来需要大概10小时样子，所以如果是野生型，周三早上应该看不到F1得
larva,P0得当然还在。
第二题：
dpy 虫子一般是表皮和结缔组织有问题吧.collagen突变什么得。但是也有影响神经得
。对生殖应该不影响吧。 |
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z****k
发帖数: 95 | 28 前两题跟我想的差不多，第三题 元芳你怎么看？人家说是留下来的那只大的是还没死
的，别的小虫都是WILD TYPE |
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w********e
发帖数: 21 | 30 1.大的那只应该是原来放进去的祖先，所以这个问题的关键是表型为什么会消失
2.没做过遗传筛选，不知道题目中的F1到底是哪一代。推测大的那只虫子的表型可能是
母源调控的（它妈妈赋予的），而虫子自身的基因型可能是纯合野生型，所以当它作为
母亲时，后代没有表型。纯属猜测。 |
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D*a
发帖数: 6830 | 31 虫子是可以自交的，应该就是那大虫子下的崽吧。
或者是虫卵？？因为它只说了make sure没有larvae，没说没有egg啊
但是也可能是大虫子下的崽都不活，只有野生型的egg活了。因为大虫子应该开始下崽
了吧 |
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g*****n
发帖数: 241 | 32 给你一些提示吧
1：看一下下面网页的life cycle，自己算一下从L1到adult需要多少时间，然后需要多
少时间从egg孵化到larvae
http://www.sfu.ca/biology/faculty/hutter/hutterlab/research/Cel
2：如果有normal head，那么应该epithelia没有影响。如果能够有后代，那么说明
muscle没有问题，reproductive tissue应该也没有问题。剩下两个你自己继续排除。
另外你可以到 www.wormbase.org 去查查 dpy mutant一般和哪些基因有关，这些基
因的功能分别是什么
3：在F1就分离到mutant，说明mutation is dominant。没有看到遗传到这个性状的后
代，说明很可能这个mutation同时也是 dominant sterile或者 dominant lethal。之
所以在F1能看到，多半是maternally rescued by P0
希望这些对你能有帮助 |
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D*a
发帖数: 6830 | 35 你这在别人看来就是回避问题啊
nature上有一篇
Nature. 2011 Sep 21;477(7365):482-5. doi: 10.1038/nature10296.
Absence of effects of Sir2 overexpression on lifespan in C. elegans and
Drosophila.
Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD,
Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM,
Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A,
Kaeberlein M, Soti C, Partridge L, Gems D.
但是鉴于nature的intro和discussion都太短，你还是找找其他杂志上的文章。
Introduction
xxx do this an... 阅读全帖 |
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l**********1
发帖数: 5204 | 36 Conti: 在PhD main advisor RL 不给全力的情况下
楼主 至少参加 (哪怕自费 不过要和 现老板事先讲明了)
有关的在美东部的 worm workshop/meetings 一次
多口头交流一些 PIs
那个可以部份弥补main RL 不给力的弱点
The Baltimore Worm Club
We are a group of scientists interested in using the nematode C. elegans to
understand biology.
Where we meet:
We meet at BS004 in the Biological Sciences Building at the University of
Maryland, Baltimore County.
Upcoming Meetings: All meetings begin at 9.00 am.
Jan 25th 2013: Gavin Woodruff (Haag Lab) & Jason Sinclair (Hamza Lab)
Feb 8t... 阅读全帖 |
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s******9
发帖数: 283 | 37 人说：
"If this takes away from any of the R01s that would normally be funded by
the NIH, it would be bad. Right now the community is already so strapped we'
re at a breaking point."
called several of its technological proposals "science fiction"
...
http://www.sciencemag.org/content/339/6123/1022.full
Brain Project Draws Presidential Interest, but Mixed Reactions
Emily Underwood*
Shortly after President Barack Obama made a seemingly innocuous pitch for
more brain research in his State of the Union... 阅读全帖 |
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l**********1
发帖数: 5204 | 38 那是 有牛人罩着
就像她师兄 Inoue T 2007-2008 在干啥 他简历上缺少这n Ys 的记录
http://medicine.nus.edu.sg/bch/pi/takaoi/about.html
but
Inoue T and Sternberg PW. (2010) C. elegans BED domain transcription factor
BED-3 controls lineage-specific cell proliferation during organogenesis. Dev
Biol. 338(2):226-36
Green JL, Inoue T and Sternberg PW. (2008) Opposing Wnt pathways orient cell
polarity during organogenesis. Cell. 134: 646-656.
Inoue T, Ailion M, Poon S, Kim HK, Thomas JH and Sternberg PW. (2007)
Genetic Analys... 阅读全帖 |
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发帖数: 1 | 39 当年在大牛组，混了cns，拿到了K99，估计k99的钱烧完没发出啥好的paper，自己单独
申请R01是没能力了，然后还是傍大腿“Machine Vision Analysis of C. Elegans
Phenotypic Patterns”/Sternberg, Paul Warren; Schafer, William R.; Zhong,
Weiwei / California Institute of Technology. 钱烧完估计还是没啥好paper，然后
跟人合作继续申请呗“The infection mechanism of the nematode virus Orsay /Tao
, Yizhi Jane; Zhong, Weiwei / Rice University” ， 总而言之，独立之后没啥成
果，但是大树底下好乘凉。 这也告诉我们，最优秀梯队的人自己创造课题，第二递推
的人接得一手好课题，第三梯度靠老课题的名声骗吃混喝，四五梯队就毫无规律 |
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P****d
发帖数: 564 | 40 I'm surprised by the numbers of R01s on basic research, so I did some search
at NIH RePORTER. I searched for active projects/R01 equivalents at NIMH,
NINDS, NIAAA and NIDA. Turned up about 400 projects with the key word
elegans, drosophila or zebrafish. Another 1,500 with mouse. Very
interesting sociology of basic research. I'm glad that you motivated me to
do the search!
I suspect that NIGMS (chemistry), NIBIB (imaging), NEI, NICHD will all
participate, perhaps a couple more ICs where the ... 阅读全帖 |
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y******8
发帖数: 1764 | 41 Here are what I did
NIH reporter,
key words: elegans, drosophila or zebrafish
Insitute: NINDS, NIMH
Application Type: New, or competing renewal
R01,
Active
return number is 29. So the average per insitute is less than 20 new R01 a
year.
Except bigbull DEISSEROTH with a grant of more than 5M a year, other costs
are routine numbers for R01.
search
to
obvious. |
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l****b
发帖数: 400 | 42 when we observe and study galaxy, how much are we helping people? same thing
when we study the development of wings and eyes in flies, or life span in c
elegans, are we really putting our science into application? my answer is
that we don't know yet the potential of these studies. might be huge in one
day, or might be nothing. Either way is fine, as long as the results are
solid.
The key issue here is, whether academic science is manipulated (or using a
less aggression expression, cherry-picked)... 阅读全帖 |
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l**********1
发帖数: 5204 | 43 C elegans RNA-binding proteins (RBPs) POS-1 and GLD-1 both proteins
recognize the glp-1 3' untranslated region (UTR) through adjacent,
overlapping binding sites and that POS-1 binding excludes GLD-1 binding.
PMID 23034181
by Farley BM et al.
POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site
cluster. (2012).
Mol Biol Cell. 23: 4473-83.
web link:
http://www.ncbi.nlm.nih.gov/pubmed/23034181 |
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p*****c
发帖数: 20445 | 44 Christopher D. Lima, Ph.D.
Memorial Sloan-Kettering Cancer Center
Christopher Lima doesn’t pick easy problems. A structural biologist, he is
investigating how cells attach small proteins—like ubiquitin and the
related molecule SUMO—to other proteins to modify their function or fate.
Alongside those studies, he is exploring the molecular mechanisms that
underlie RNA processing and degradation—modifications to an RNA copy of a
gene that influence its stability and ability to be used as a template ... 阅读全帖 |
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w***a
发帖数: 432 | 45 这片文章里有讲过一点。和shRNA一样表达。
@Article{Chen2004,
Title = {MicroRNAs modulate hematopoietic lineage
differentiation.},
Author = {Chang-Zheng Chen and Ling Li and Harvey F
Lodish and David P Bartel},
Journal = {Science},
Year = {2004},
Month = {Jan},
Note = {mark},
Number = {5654},
Pages = {83--86},
Volume = {303},
Abst... 阅读全帖 |
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u*********1
发帖数: 2518 | 46 其实你的第一段的“animal world”的定义具体是什么呢？野生？驯化？还是both？
关于野生动物同性恋行为的研究，我其实很好奇研究的可行性，因为你要跟踪研究野生
动物应该是很难的吧？换言之，我们应该是缺少这方面数据的。而仅有的少数数据应该
也是驯养的吧？这就好比我们在实验室做c elegans/drosophila一样
当然了，如果驯养动物的同性恋比例真的比野生的高很多，比如你说的这个10%，我感
觉真的是很高的比例了，那还或许真是这个挑选驯化过程会对性取向有影响。这是个很
有趣的观察角度。
其实我觉得要从进化的角度解释同性恋，首先一个很根本的话题就是：请从进化的角度
来解释“性”，以及“性”和“生育”的关系。
要讨论这个问题，先要说明到底什么是“同性恋”。这听起来非常愚蠢，但坦白说我觉
得很多人根本不知道何为“同性恋”，包括很多pro-gay的亲友甚至同性恋自己也不一
定很清楚。比如我遇到很多liberal派的人，他们说支持同性恋，就是因为只要是真爱
，所以就支持。我当然很感激这样的人，但坦白说他们不知道什么是gay。只要是真爱
所以就支持，那如果一个人和一条狗也真爱，是否也... 阅读全帖 |
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g***n
发帖数: 14 | 47 谢谢你详细的回复
我的mutant实际上还有很多noise，原因是我的线虫体外回交成功率极低，这也是为什么
而且，我研究的线虫基因组还没有发表，所以也没有common variants数据库了，我这
个搞非模式生物的也只能流口水
所谓的wildtype A和B，是同一个isolate里发现的，理论上来说genome的variation很
小，测序数据也证明了这点
其中一个问题是，两个wildtype的差异基因很可能是控制上游表达的，而mutant中的
candidates基本都靠近下游。这是通过研究c elegans的ortholog 得出的结论。但不是
很肯定，因为线虫间的差异很大。
另外，我手上还有两个wildtype在stage L2的transcriptome，这个stage是所谓
phenotype的决定期。通过分析发现不到30个基因差异表达。有没有什么方法可以把
genome和transcriptome放在一起做个cross analysis的？
你上一个回复中提到的structure variation，是指rna的还是蛋白的？是怎么做呢？如
果有已经发表的文章，能不能给... 阅读全帖 |
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T****u
发帖数: 424 | 48 NIBS:
王晓东: Several key molecules in necroptosis(RIP3,MLKL etc)
邵峰: Mechanism of pathogen-host interaction
(key:NLRC4 recognize flagellin)
李文辉 NTCP as HBV receptor <======milestone
张宏: Delineate autophagy in C.elegan
朱冰：Histone code
厦大：
韩家怀: one key molecule in necroptosis(RIP3)
上海生化所:
徐国良mechanism of DNA demethylation;
李劲松 haploid ES
动物所
周琦 transgenic mice using androgenetic haploid embryonic stem
北京大学
邓鸿奎 CiPS <======milestone
CiPS is more important... 阅读全帖 |
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D*a
发帖数: 6830 | 49 老鼠里面一堆KO各种基因引起寿命延长的了，到现在sirtuin系列的蛋白一个这种结果
都没有。然后在果蝇和线虫里面的结果还被人以
Absence of effects of Sir2 overexpression on lifespan in C. elegans and
Drosophila 这种标题发到nature上了。
看了看那几个做sirtuin的实验室，做anything but aging但是都宣称自己做aging，也
是奇葩了。
对绝大多数物种来说aging 本身就不是一个evolutionary trait，很难有aging
specific的东西。 |
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E**********t
发帖数: 56 | 50 Xuebiao Yao, Dasheng Li and Gang Pei recently wrote an essay to Nature
Review in MCB Which is entitled “In focus: molecular and cell biology
research in China”. Here is the link: http://www.nature.com/nrm/journal/v14/n9/full/nrm3638.html In this article, they discussed the past, present and future of molecular and cell biology research in China. One part which interested me is the key MCB discoveries in China. Although most of the work are nice and likely solid work, few of them are breakthrough... 阅读全帖 |
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