c*g
发帖数: 1980 | 1 Olemiss
(To Chang Maomao, incarnated March, 1997; quit the earth December, 2010. He
was one of a cat.)
* The dark side of the night *
I thought I was very tired. But when I walked out of the Inn and into the
warm September night, I was healed. It had rained in the afternoon, the
Alumni Drive was wet reflecting the bright street lights. I walked towards
the dark.
I followed a runner wearing a white T-shirt for half-of-a-minute. He was
young and energetic; soon he disappeared from my sight. A ... 阅读全帖 |
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c****t
发帖数: 19049 | 2 THE PACIFIC JOURNAL OF ADAM EWING
Thursday, 7th November—
Beyond the Indian hamlet, upon a forlorn strand, I happened on a trail of
recent footprints.
Through rotting kelp, sea cocoa-nuts & bamboo, the tracks led me to their
maker, a White man,
his trow-zers & Pea-jacket rolled up, sporting a kempt beard & an outsized
Beaver, shoveling
& sifting the cindery sand with a teaspoon so intently that he noticed me
only after I had hailed
him from ten yards away. Thus it was, I made the acquaintance of... 阅读全帖 |
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g****n
发帖数: 13 | 3 Could anyone send me a copy of this paper?
Mechanisms of neural patterning and specification in the developing
cerebellum.
Annu. Rev. Neurosci. 1995 (18): 385–408.
Thanks for your help. |
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S*****s
发帖数: 287 | 4 I need to dissect out microstructures of mouse brain, such as cerebellum,
hippocampus, thalamus, etc. We have never done this in our lab before, so
our tools suck. But I do not want to waste money to order a random selection
on Fisher or VWR catalog. There are so many neuroscientists on this board.
Could you please let me know what are your favorite microdissection tools? I
need to order all the surgical tools to remove the head, take out brain,
and do actual dissection to get the substructures.... 阅读全帖 |
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m*********n
发帖数: 215 | 5 stereomicroscope，那个有自带的黑色背景台。#10 surgical blade和＃5 镊子足够了。E12.5到p14都做过，在dish中加1Xpbs dissect。cerebellum, thalamus还有hippocampis都是这么明显的结构。。。 |
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l*******r
发帖数: 39279 | 6 Cerebellar cortical inhibition and classical eyeblink conditioning.
Bao S, Chen L, Kim JJ, Thompson RF.
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1592-7. Epub 2002 Jan 22.
Learning- and cerebellum-dependent neuronal activity in the lateral pontine
nucleus.
Bao S, Chen L, Thompson RF.
Behav Neurosci. 2000 Apr;114(2):254-61.
Impaired cerebellar synapse maturation in waggler, a mutant mouse with a dis
rupted neuronal calcium channel gamma subunit.
Chen L, Bao S, Qiao X, Thompson RF.
Proc Natl Acad... 阅读全帖 |
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s*******d
发帖数: 1079 | 7 学友MILK找到的这个FA ２０１１版 vs ２０１０版的详细对照，我觉得很有帮助，放
在这儿给大家做参考吧。
原文见 http://forums.studentdoctor.net/showthread.php?t=785943
Overall:
- FA 2011 corrects some of the 2010 errata
- FA 2011 has darker print and thicker pages
- FA 2011 increases the size of most figures/images (although only slightly)
- FA 2011 removes several images that are difficult to see/interpret
Behavioral Science:
p. 59-60 2010 (57-58 2011) -2011 reorganized a couple items into "Advance
directives" and got rid of "Good Samaritan Law.... 阅读全帖 |
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x*******8
发帖数: 68 | 8 2nd one
3-14
A 67 year old woman is brought to the ED because of the inability move the
right side of her body since awakening this morning.. she has type 2
diabetes mellitus. Her blood pressure is 170/95. Exaniation shows dysarthric
speech, but language function is normal. Cranial nerves are intact except
for moderate weakness of the right low face. She is unable to move the right
upper or lower extremities. Sensation is intact. There is hyperreflexia of
the right upper and lower extremities. A... 阅读全帖 |
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r**********n
发帖数: 9 | 9 Sorry for the sad news about your lovely baby.
ATRT的预后非常差，是肯定的。
如果你想尝试St. Jude or Boston，您可以直接与他们联系。复制并翻译所有的医疗记
录。如果他们接受你的宝宝，通常你需要提前支付作为一个国际病人。St. Jude 是研
究医院，可能对美国人免费。不知对国际病人如何。
因为它是ATRT，你要想清楚你花代价是想要什么结果。
以下转自UpToDate:
Atypical teratoid/rhabdoid tumors — CNS atypical teratoid/rhabdoid tumors (
ATRTs) are highly malignant tumors primarily occurring in young children
less than three years old [91]. Histologically, ATRTs are characterized by
rhabdoid cells and are similar to that of other small ro... 阅读全帖 |
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o******h
发帖数: 198 | 10 国内同学的小女孩4岁纤维瘤 想报名这里clinical trial
大家帮我看一下 哪里要修改的
检查部位和名称：头颅增强
检查技术：FLASHT1 ,TSE T2,T2 tirm dark-fluid,DWI, 对比剂采用0.5mmol /ML 欧乃
影，外周静脉推注
放射学表现：左侧基底节区，脑干及双侧小脑可见多发斑片状高信号，增强后未见异常
强化灶，脑室系统未见明显扩大，中线结构居中。DWI未见异常高信号。
Examination location : head Enhanced
Examination: head Enhanced Inspection techniques: FLASHT1, TSE T2, T2 tirm
dark-fluid, DWI, contrast agents using 0.5mmol / ML Omniscan, peripheral
intravenous injection Radiological findings: the left basal ganglia, brain
stem and cerebellum shows multi... 阅读全帖 |
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o*******t
发帖数: 167 | 11 本版太冷清了 我来唐一下
-------------------------
考过两天了 比我想象的难
早上7点半就去了 结果还是不够早 一堆小孩在排队 一问 居然大部分都是考 NAPLEX
来自各个学校的都有 Dallas过来的就有三个 说是Dallas地区直到九月份的位子都没了
只好约到我们这边来 一屋子的女生 相互谦让之后我就排到最后一个了 照相打掌纹搜
检衣服后进考场
一开始状态就不好 周边噼噼啪啪的在打键盘很吵 还有转椅拖动的时候也很有大的响声
人很多的缘故 各人break的时间也不尽相同 开始考试后才发现阅读instruction和看
test example也都算时间了
另外鼠标好像也不好使 很容易一个click直接翻两页 需要按previous做被跳过的题 最
后做数学题的时候给的笔居然是坏的 还要举手换一支 这些都算时间的 比较抓麻
QA: 很多初中的函数题 对数题 极限值 反函数 不连续函数等 这些比较简单 吃惊的是
微积分很多 好几道三角函数类的积分 统计和概率的也有几道 公式都不太记得了 现场
推理也还行 要么就是猜 就是时间比较紧 中间有一道题是很长的一段文... 阅读全帖 |
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A*******s
发帖数: 9638 | 12 The patient was confused on the day of admission. Next day, she was much
more awake. I noticed she has a right INO, all other exams had no change.
MRI showed a brain stem infarct, 2 small infarcts in cerebellum.
ECHO shows no clots.
EEG was nl.
CMP at admission including Glucose was 126. |
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n*******c
发帖数: 501 | 13 Very interesting case.
I wonder where the brain stem infarct is. Are they (with cerebellum infarct)
acute? How is the blood flow in vertebral arteries?
My impression is that the syncope was due to brain stem infarct rather than
SSS. SSS is probably an incidental finding.Having said that I haven't seen a
case with retrograde basilar flow from SSS(just realize our hosp doppler
ultrasound never reports basilar :( ）
Has the patient had syncope before?
Just for my curiosity. Did the MRA showing SSS ... 阅读全帖 |
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R*******t
发帖数: 367 | 14 Time of flight will give you information of flow direction, while contrast
MRA doesn't. As long as there is flow in a vessel, retrograde or ante grade,
it will light up with contrast enhancement. In time of flight, retrograde
flow will lose signal and the vessel would be dark.
发信人: newprozac (中人), 信区: Medicalpractice
标 题: Re: 【case discussion】 Syncope
发信站: BBS 未名空间站 (Mon Feb 6 03:22:35 2012, 美东)
Very interesting case.
I wonder where the brain stem infarct is. Are they (with cerebellu... 阅读全帖 |
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A*******s
发帖数: 9638 | 15 The patient was confused on the day of admission. Next day, she was much
more awake. I noticed she has a right INO, all other exams had no change.
MRI showed a brain stem infarct, 2 small infarcts in cerebellum.
ECHO shows no clots.
EEG was nl.
CMP at admission including Glucose was 126. |
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n*******c
发帖数: 501 | 16 Very interesting case.
I wonder where the brain stem infarct is. Are they (with cerebellum infarct)
acute? How is the blood flow in vertebral arteries?
My impression is that the syncope was due to brain stem infarct rather than
SSS. SSS is probably an incidental finding.Having said that I haven't seen a
case with retrograde basilar flow from SSS(just realize our hosp doppler
ultrasound never reports basilar :( ）
Has the patient had syncope before?
Just for my curiosity. Did the MRA showing SSS ... 阅读全帖 |
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R*******t
发帖数: 367 | 17 Time of flight will give you information of flow direction, while contrast
MRA doesn't. As long as there is flow in a vessel, retrograde or ante grade,
it will light up with contrast enhancement. In time of flight, retrograde
flow will lose signal and the vessel would be dark.
发信人: newprozac (中人), 信区: Medicalpractice
标 题: Re: 【case discussion】 Syncope
发信站: BBS 未名空间站 (Mon Feb 6 03:22:35 2012, 美东)
Very interesting case.
I wonder where the brain stem infarct is. Are they (with cerebellu... 阅读全帖 |
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A*******s
发帖数: 9638 | 18 人脑的可塑性很强，伦敦taxi司机的这个研究对传统观念--人的智商就是天生的是一
个挑战。 相反， 通过早期的， 针对性的，并且是长期的训练，人生的轨道是完全可
以改变的。
我现在越来越相信没有教不会的学生， 只有教不好的老师。
根据这篇文章， jeremy lin的大脑最可能有什么改变？
1. Frontal lobe
2. Temporal lobe
3. Parietal Lobe
4. Occiptal lobe
5. Limbic system
6. Cerebellum
http://www.cell.com/current-biology/retrieve/pii/S0960982211012 |
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h*******r
发帖数: 182 | 19 Intractable nausea, ataxia... Could she have paraneoplastic syndrome
affecting cerebellum? I would like to check tumor markers and PET/CT for
occult malignancy. |
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m******1
发帖数: 95 | 20 connectivity指的是神经元之间的拓扑关系，这种复杂的拓扑关系可能是神经网络能完成复杂功能的根本原因，也可能只是要素之一。所以一部分人包括我们认为，connectivity虽然重要，但可能并不是脑运算能力如此强大的最根本原因。有过一系列的实验证据表明，皮层这一级别的神经结构类似于通用计算机，连到visual input上就能做视觉处理，连到auditory input上就能做声音处理。这就好比说只要某块脑有足够数量的神经元，和足够多的互联，它就有了足够的信息表征能力（信息熵），至于具体怎么连接，未必重要。
不过这种观点仅仅限于皮层这种“通用结构”，一旦考虑到不同级别的神经结构譬如basal ganglia, cerebellum, spinal cord的互联，那connectivity就变得非常重要了。你说的计算机主板的例子很恰当，主板正是cpu、内存、板卡这些不同结构的互联，所以线打乱了就别玩了。通用结构不是主板，而是更类似于可编程的通用芯片，把互联的能力预留好就行，至于具体怎么连等用的时候再说。但类似Blue Brain的项目看上去不是在重建整个神经系统，而恰恰是在重建脑... 阅读全帖 |
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f**d
发帖数: 768 | 21 挺好的论点
请给下你说的那几篇neural computational文章的链接
想仔细读读再讨论
谢！
完成复杂功能的根本原因，也可能只是要素之一。所以一部分人包括我们认为，
connectivity虽然重要，但可能并不是脑运算能力如此强大的最根本原因。有过一系列
的实验证据表明，皮层这一级别的神经
basal ganglia, cerebellum, spinal cord的互联，那connectivity就变得非常重要了
。你说的计算机主板的例子很恰当，主板正是cpu、内存、板卡这些不同结构的互联，
所以线打乱了就别玩了。通用结构:
有的信息传递都是通过随机spiking来完成的。Spiking network最近是个热门话题，人
们的逐渐意识到这种信息传递的机制有很多意想不到的好处。关于这一点，我们有几篇
发在Neural Computation上的文
。。
不等 |
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k*****1
发帖数: 454 | 22 I am interested in your paper. Any link? thanks!
完成复杂功能的根本原因，也可能只是要素之一。所以一部分人包括我们认为，
connectivity虽然重要，但可能并不是脑运算能力如此强大的最根本原因。有过一系列
的实验证据表明，皮层这一级别的神经结构类似于通用计算机，连到visual input上就
能做视觉处理，连到auditory input上就能做声音处理。这就好比说只要某块脑有足够
数量的神经元，和足够多的互联，它就有了足够的信息表征能力（信息熵），至于具体
怎么连接，未必重要。
basal ganglia, cerebellum, spinal cord的互联，那connectivity就变得非常重要了
。你说的计算机主板的例子很恰当，主板正是cpu、内存、板卡这些不同结构的互联，
所以线打乱了就别玩了。通用结构不是主板，而是更类似于可编程的通用芯片，把互联
的能力预留好就行，至于具体怎么连等用的时候再说。但类似Blue Brain的项目看上去
不是在重建整个神经系统，而恰恰是在重建脑皮层这种通用结构。我不妨再次丢出这个
激进... 阅读全帖 |
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m***f
发帖数: 1622 | 23 interesting research,
Fossil Evidence on Origin of the Mammalian Brain
science
05/20/2011 332: 955
Many hypotheses have been postulated regarding the early evolution of
the mammalian brain. Here, x-ray tomography of the EarlyJurassic
mammaliaforms Morganucodon and Hadrocodium sheds light on this history.
We found that relative brain size expanded to mammalian levels, with
enlarged olfactory bulbs,neocortex, olfactory (pyriform) cortex, and
cerebellum, in two evolutionary pulses. The initial puls... 阅读全帖 |
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a**e
发帖数: 5094 | 24 the MRI report did not mention anything about "brain tumor" . it only says
"neural degenerative disease"
if the NF-1 diagnosis is correct, the most common brain tumor is high grade
glioma, which carry better prognosis.
her eye jerking is most like associated with the leisions in the cerebellum. |
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