V*******s
发帖数: 19 | 1 Does anyone know how to make supported Lipid Bilayers? I want to set up some
experiments to study T cells immunological synapses.
Thanks for help. |
|
f**d
发帖数: 768 | 2 这是一本计算神经科学的优秀著作，全文拷贝这里（图和公式缺），有兴趣的同学可以
阅读
如需要，我可以分享PDF文件（－－仅供个人学习，无商业用途）
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖 |
|
d*********o
发帖数: 6388 | 3 http://news.163.com/photoview/3R710001/55664.html#p=9ON4FM1B3R7
这是一组在内地的新疆人的故事，无关宗教或政治宏旨。这群因为离开家乡而被打上了
特殊标签的人，在镜头中展现了他们最平常、最卑微、也最动人的一面。 摄影/库尔班
江·赛买提 编辑/翁倩 (由于四处寻找纪录片的资金无果，库尔班江先开始了图片专题
的采访和拍摄，为了不浪费时间，也为了给纪录片做个预备和铺垫。)
我叫茹仙古丽·艾力，我从新疆来，维吾尔族。我今年25岁，在北京十年了。现在在一
家阿拉伯餐厅演出。我今年想学英语，希望以后有机会参加国际上的阿拉伯舞比赛。
我叫乃菲莎·尼合买提，我从新疆来，维吾尔族，今年35岁。我2008年从华东政法大学
毕业，现在在上海金杜律师事务所做执业律师，今年开始我在美国埃默里大学法学院攻
读比较法硕士研究生。我现在的梦想是竞选成为一名全国人大代表，争取保护和促进少
数民族女性的权利。
我叫博斯坦妮娅，我从新疆来，维吾尔族，今年30岁，现在任阿里巴巴集团淘宝天下品
牌广告部总监。我在杭州工作和生活，距离我的家乡新疆博尔塔拉自治州4412... 阅读全帖 |
|
w******9
发帖数: 1604 | 4 Submitted
Missel AR, Bai M, Klug WS, Levine AJ, The Affine to Non-affine Transition in
Anisotropic Semiflexible Networks.
Roos WH, Gibbons MM, Arkhipov A, Uetrecht C, Watts NR, Wingfield PT, Steven
AC, Heck AJR, Schulten K, Klug WS, Wuite GJL, Squeezing protein shells: how
continuum elastic models, moleculardynamics simulations and experiments
coalesce at the nanoscale.
Published
Morozov AY, Rudnick J, Bruinsma RF and Klug WS, Assembly and Disassembly of
Deltahedral Viral Shells. In: Stockley, P... 阅读全帖 |
|
发帖数: 1 | 5
Download pdf published by SfN (Chapter from 'The History of Neuroscience in
Autobiography, Volume 8' edited by Larry R. Squire)
Yuh-Nung Jan's CV
Lily Jan's CV
Yuh-Nung Jan and Lily Jan
Birth
Family History and Growing Up
National Taiwan University
The Hiking Trip to Shitou in the Spring of 1967
Graduate School Application
Graduate Study at Caltech (1968锟974)
Seymour Benzer Lab (1974锟977)
Steve Kuffler锟絪 Lab at H... 阅读全帖 |
|
x********e
发帖数: 35261 | 6 1. 为什么要摄入脂类（lipids）
脂类主要包括脂肪酸（fatty acids），脂肪酸衍生物（甘油酯，磷脂，鞘脂等）和固
醇类。
与碳水化合物类似，脂类是能量的来源。如果把糖比作流通的货币，那我会把油脂比作
金子，因为单个脂分子所能提供的能量远大于糖，并且脂肪是能量存储的主要形式。从
能量来源的角度看，脂类可由碳水和蛋白质替代。但被很多人忽视的一点是摄入脂类的
必须性。
生物膜系统，包括细胞膜和细胞内各种细胞器膜，都是以lipid bilayer构成。生长发
育期的孩子，需要进行大规模的细胞增殖以满足器官组织的增长。而每一个新细胞的形
成都需要用脂类作为基石。另外，大脑的发育和神经网络的架构是儿童发育时期的重中
之重。而神经细胞对生物膜的需求又特别高。所以老有广告吹什么DHA提高儿童智力。
就算是成年人，身体内的细胞也是会不断衰老并被新的细胞取代。学习和记忆也需要不
断重塑神经网络。
其次，人体必须的各种激素和维生素是固醇衍生物。固醇的缺乏会造成内分泌紊乱。
最后，也是很多人会忽略的一点是，蛋白质的消化吸收是需要脂类的。肠道内的蛋白质
需要经过乳化才能被吸收。乳化所需的脂类，一部... 阅读全帖 |
|
发帖数: 1 | 7 Two research assistantships are available for PhD students in the Integrated
BioMicroFluidis Laboratory http://faculty.cua.edu/luox in the Department of Mechanical Engineering at the Catholic University of America (CUA), a private research university in downtown Washington DC. Research assistantships cover living expense and full tuition.
The first student will work on biofabrication in microfluidics for bacterial
chemotaxis and cell-cell signaling studies. The second student will work
on t... 阅读全帖 |
|
l**j
发帖数: 40 | 8 看看下面就知道我们在美国的大部分人很WS.
代表性论文（引用率>1300, H-index=23）
1. Y. Z. Long, L. Liao*, X. F. Duan, Z. Y. Fan*, Large-scale
Integration of Semiconductor Nanowires for High Performance Flexible
Electronics ACS Nano (In press)
2. L. Liao, J. W. Bai, R. Chen, H. L. Zhou, L. X. Liu, Y. Liu, Y.
Huang, X. F. Duan, Scalable Fabrication of Self-Aligned Graphene Transistors
and Circuits on Glass Nano Lett. (In Press).
3. L. Liao, X. F. Duan Graphene-based RF devices Materials Today (In
Press).
4. ... 阅读全帖 |
|
m**********g
发帖数: 44 | 9 TITLE: Bilayers of Janus WSSe: Monitoring the Stacking Type via Vibrational
Spectrum
你的名字，title， 邮件，和 comments (给编辑的），没有comments 也没有关系，我
就空着。
在线等。 |
|
V*******s
发帖数: 19 | 10 有没有人制备过lipid bilayer？ 我有一课题需要用到它做T 细胞 imaging。
多谢！ |
|
a***a
发帖数: 40617 | 11 那是磷脂，两性的，然后形成bilayers，你还是不懂啊 |
|
r*c
发帖数: 16750 | 12 发信人: Closingbell (转我的贴记住给包子~), 信区: Military
标 题: 英特尔科学奖2016年40人决赛名单出炉 11名华裔学生入围
发信站: BBS 未名空间站 (Thu Jan 21 09:21:35 2016, 美东)
据英特尔科学奖官方网站消息。英特尔科学奖20日公布入围决赛名单。在这份40人的决
赛名单里，共有11名华裔学生入围。
占入围人数近三成的华裔学生分别来自加州，康州，马里兰州，宾州，纽约州和密苏里
州。其中加州和纽约州分别有三名华裔学生入围，马里兰州有两位。
英特尔科学奖（Intel Science Talent Search）是美国一个科学奖项，原本称为西屋
科学奖（Westinghouse Science Talent Search），颁发给优秀的高中学生。英特尔科
学奖是西屋公司于1942年所创设，1998年改称为英特尔科学奖。美国总统乔治•
赫伯特•沃克•布什曾说英特尔科学奖“是科学界的超级碗”。许多著名的
科学家都曾获得该奖，包含罗德•霍夫曼、戴维•芒福德、谢尔登... 阅读全帖 |
|
a***e
发帖数: 757 | 13 【 以下文字转载自 Chemistry 讨论区 】
发信人: aubie (diode), 信区: Chemistry
标 题: paper help, thanks-from Helvetica Chimica Acta
发信站: BBS 未名空间站 (Thu Jan 21 15:16:47 2010, 美东)
Anybody who can download from this journal, please help, many thanks.
Helvetica Chimica Acta
Volume 77 Issue 1, Pages 351 - 371, 2004
Organic Diodes Based on Redox-Polymer Bilayer-Film-Modified Electrodes
Wenyuan Zhao, Judith Marfurt, Lorenz Walder * |
|
r********e
发帖数: 49 | 14 一般如果把cell放到纯水里面，水会由于osmotic pressure的平衡大量进入cell中，并
会burst。以下两篇文献主题似在讲如何解决这个问题。本人对生物一窍不通，看不懂
，可有高人指点一下主旨是怎样解决的吗？万分感谢!!
Science 29 August 2008:
Vol. 321 no. 5893 pp. 1210-1214
DOI: 10.1126/science.1159674
Report
A Structural Mechanism for MscS Gating in Lipid Bilayers
Science 29 August 2008:
Vol. 321 no. 5893 pp. 1166-1167
DOI: 10.1126/science.1162963
Perspective
BIOCHEMISTRY
Opening the Molecular Floodgates |
|
S**********e
发帖数: 1789 | 15 Vanderbilt University School of Medicine
Lopez, Carlos F , Ph.D. Assistant Professor of Cancer Biology
Publications
Giovambattista, N, Lopez, CF, Rossky, PJ, Debenedetti, PG. Hydrophobicity of
protein surfaces: Separating geometry from chemistry. Proc Natl Acad Sci U
S A, 105(7), 2274-9, 2008. PMCID:2268126
Lopez, CF, Darst, RK, Rossky, PJ. Mechanistic elements of protein cold
denaturation. J Phys Chem B, 112(19), 5961-7, 2008. PMCID:2268126
Lopez, CF, Nielsen, SO, Srinivas, G, Degrado, ... 阅读全帖 |
|
E**********1
发帖数: 19 | 16 1. okay, first of all, I really don't know PDB actually provides predicted
3D models for every single PDB entry--maybe I am outdated. But if you could
provide everybody here with an example or a link, that would be very
helpful. I
am not sure if you are talking about homolog structures or homology
modeling. Neither is accurate information. Homology modeling is very
challenging especially when sequence homology is low. Often you cannot find
solved homolog structures to do that, am I right? ... 阅读全帖 |
|
m********8
发帖数: 314 | 17 求帮助下载一片老文献。十分感谢。
Transport of protons and hydrochloric acid through lipid bilayer membranes.
Biochim Biophys Acta. 1981 Feb 20;641(1):183-8. |
|
s****l
发帖数: 10462 | 18 NIH最近又房顶了八个小组，大家看看哪一个最有可能成功？
The new grants are awarded (pending available funds) to:
University of California Santa Cruz, $2.29 million over three years
Principal Investigator: Mark Akeson, Ph.D.
Investigators plan to sequence single DNA molecules by using a nanopore
device comprised of a sensor that touches, examines and identifies each
nucleotide, or DNA building block, in a DNA strand as an enzyme motor moves
it through the pore. The scientists will focus on DNA “resequencing” —
examining th... 阅读全帖 |
|
s****l
发帖数: 10462 | 19 NIH最近又房顶了八个小组，大家看看哪一个最有可能成功？
The new grants are awarded (pending available funds) to:
University of California Santa Cruz, $2.29 million over three years
Principal Investigator: Mark Akeson, Ph.D.
Investigators plan to sequence single DNA molecules by using a nanopore
device comprised of a sensor that touches, examines and identifies each
nucleotide, or DNA building block, in a DNA strand as an enzyme motor moves
it through the pore. The scientists will focus on DNA “resequencing” —
examining th... 阅读全帖 |
|
l***i
发帖数: 36 | 20 It depends on your purpose. You can use anti-CD3 or anti-TCR antibody to
activate T cells. Otherwise, you can try lipid bilayer loading with MHC+
peptide. |
|
s******c
发帖数: 331 | 21 这个，非磷酸化receptor都和arrestin有robust的作用，那G protein怎么办？多数的
GPCR的C terminus都是结合arrestin重要的位点，磷酸化与否是arrestin结合的关键因
素，虽然有些例外。receptor和arrestin结合不稳定并不是指affinity，而是整个过程
非常的dynamic，传统的观念，也是这篇文章的point，就是arrestin结合C terminus，
然后再构象变化结合到G protein结合位点上。但实际上，很多receptor结合arrestin
但是不internalize，或者结合arrestin但是没有arrestin signaling，这些都不是这
个简单的模型可以回答的，实际结合过程可能更为复杂，不是一个单一或均一affinity
的状态，甚至还有可能需要其它蛋白的帮助。如果真affinity很高，这篇文章里也不会
把他们fuse在一起。另外lipid肯定是有作用的，很多细胞外研究他们相互作用的都要
把receptor构建到lipid bilayer的环境里，可能我孤陋寡闻，但是我还没见过直接在
d... 阅读全帖 |
|
发帖数: 1 | 22 Two research assistantships are available for PhD students in the Integrated
BioMicroFluidis Laboratory http://faculty.cua.edu/luox in the Department of Mechanical Engineering at the Catholic University of America (CUA), a private research university in downtown Washington DC. Research assistantships cover living expense and full tuition.
The first student will work on biofabrication in microfluidics for bacterial
chemotaxis and cell-cell signaling studies. The second student will work
on t... 阅读全帖 |
|
发帖数: 1 | 23 Two research assistantships are available for PhD students in the Integrated
BioMicroFluidis Laboratory http://faculty.cua.edu/luox in the Department of Mechanical Engineering at the Catholic University of America (CUA), a private research university in downtown Washington DC. Research assistantships cover living expense and full tuition.
The first student will work on biofabrication in microfluidics for bacterial
chemotaxis and cell-cell signaling studies. The second student will work
on t... 阅读全帖 |
|
y*******n
发帖数: 127 | 24 Title: Manipulation and charge determination of proteins in photopatterned
solid supported bilayers
Journal: INTEGRATIVE BIOLOGY
Author: Xiaojun Han, Matthew R. Cheetham, Khizar Sheikh, Peter D. Olmsted,
Richard J. Bushby and Stephen D. Evans
Year,Volume and page: 2009, 1, 205 - 211
URL: http://www.rsc.org/publishing/journals/IB/article.asp?doi=b815601h |
|
a***e
发帖数: 757 | 25 Anybody who can download from this journal, please help, many thanks.
Helvetica Chimica Acta
Volume 77 Issue 1, Pages 351 - 371, 2004
Organic Diodes Based on Redox-Polymer Bilayer-Film-Modified Electrodes
Wenyuan Zhao, Judith Marfurt, Lorenz Walder * |
|
d********y
发帖数: 176 | 26 what kind of membrane system are you using? vesicle? supported bilayer? |
|
|
r********e
发帖数: 49 | 28 一般如果把cell放到纯水里面，水会由于osmotic pressure的平衡大量进入cell中，并
会burst。以下两篇文献主题似在讲如何解决这个问题。本人对生物一窍不通，看不懂
，可有高人指点一下主旨是怎样解决的吗？万分感谢
Science 29 August 2008:
Vol. 321 no. 5893 pp. 1210-1214
DOI: 10.1126/science.1159674
Report
A Structural Mechanism for MscS Gating in Lipid Bilayers
Science 29 August 2008:
Vol. 321 no. 5893 pp. 1166-1167
DOI: 10.1126/science.1162963
Perspective
BIOCHEMISTRY
Opening the Molecular Floodgates |
|
a*********r
发帖数: 14 | 29 对不起，我还真是给武大化学系留了面子。
莫非你就是其中一件丑事的主角，干嘛一触即发，破口大骂呢？
袁荃做的是还不错，但不意味武大化学系就有多好了。
举例来说，即使袁荃和另外一位新招的楚天特聘教授傅磊相比，也能看出武大化学系在其中有没有猫腻了。
首先补充一点：袁荃的老公叫廖蕾，也是武大物理系新招的楚天特聘教授，可以作为很好的对照体系。
比比三人的publication和经历，就能明显看出水平之比是:
廖蕾>袁荃>傅磊
但从袁荃却没有评上楚天特聘。
廖蕾
http://physics.whu.edu.cn/node/557
1. Y. Z. Long, L. Liao*, X. F. Duan, Z. Y. Fan*, Large-scale Integration of Semiconductor Nanowires for High Performance Flexible Electronics ACS Nano (In press)
2. L. Liao, J. W. Bai, R. Chen, H. L. Zh... 阅读全帖 |
|
a*********r
发帖数: 14 | 30 对不起，我还真是给武大化学系留了面子。
莫非你就是其中一件丑事的主角，干嘛一触即发，破口大骂呢？
袁荃做的是还不错，但不意味武大化学系就有多好了。
举例来说，即使袁荃和另外一位新招的楚天特聘教授傅磊相比，也能看出武大化学系在其中有没有猫腻了。
首先补充一点：袁荃的老公叫廖蕾，也是武大物理系新招的楚天特聘教授，可以作为很好的对照体系。
比比三人的publication和经历，就能明显看出水平之比是:
廖蕾>袁荃>傅磊
但从袁荃却没有评上楚天特聘。
廖蕾
http://physics.whu.edu.cn/node/557
1. Y. Z. Long, L. Liao*, X. F. Duan, Z. Y. Fan*, Large-scale Integration of Semiconductor Nanowires for High Performance Flexible Electronics ACS Nano (In press)
2. L. Liao, J. W. Bai, R. Chen, H. L. Zh... 阅读全帖 |
|
|
x*******u
发帖数: 221 | 32 Chemical vapour deposition growth of large single crystals of monolayer and
bilayer graphene
Nature Communications 4, Article number: 2096 doi:10.1038/ncomms3096
多谢
我的e-mail 是： c********[email protected] |
|
|
发帖数: 1 | 34 Two research assistantships are available for PhD students in the Integrated
BioMicroFluidis Laboratory http://faculty.cua.edu/luox in the Department of Mechanical Engineering at the Catholic University of America (CUA), a private research university in downtown Washington DC. Research assistantships cover living expense and full tuition.
The first student will work on biofabrication in microfluidics for bacterial
chemotaxis and cell-cell signaling studies. The second student will work
on t... 阅读全帖 |
|
g*****l
发帖数: 5 | 35 现在越来越怀疑mse的就业前景了，不知道mse目前在美国找工作情况怎么样？哪些
方向找工作比较不困难？
我目前做lipid bilayer membrane, 又生物又纳米的，不知道还要不要继续做下去
，还是赶紧换方向？
|
|
发帖数: 1 | 36 Two research assistantships are available for PhD students in the Integrated
BioMicroFluidis Laboratory http://faculty.cua.edu/luox in the Department of Mechanical Engineering at the Catholic University of America (CUA), a private research university in downtown Washington DC. Research assistantships cover living expense and full tuition.
The first student will work on biofabrication in microfluidics for bacterial
chemotaxis and cell-cell signaling studies. The second student will work
on t... 阅读全帖 |
|
s*********s
发帖数: 18 | 37 graphene 研究的一个问题（请教前辈）：
graphene 在电场的gate的作用下，可以打开bandgap,i.e bilayer----- tunnable
bandgap, trilayer -----overlap band gap.
1.那么在perpendicular magnetic field 的作用下，graphene 的情况如何呢？
bandgap 能打开？ 还是打开excitonic condensation gap?还是其他情况？？
2. four-terminal graphene device 在perpendicular magnetic field 的作用下，发
现测量的电阻（不是hall effect 磁阻）线性或者非线性的随着磁场增加而增加，也就
是： R vs B， 这个如何解释？
希望前辈指教！ |
|
R******d
发帖数: 5739 | 38
ur molecule need to be lipophilic in order to pass the cell membrane(lipid
bilayer), if it is hydrophilic, then u need active transport. but as what u
said, too lipophilic will decrease solubility and cause PK, protein binding
, etc. problems. it is a balance. in some cases i saw solubility gave in
to potency, then people will try to make salt, or prodrugs to get around the
solubility problem |
|
s*********s
发帖数: 18 | 39 graphene 研究的一个问题（请教前辈）：
graphene 在电场的gate的作用下，可以打开bandgap,i.e bilayer----- tunnable
bandgap, trilayer -----overlap band gap.
1.那么在perpendicular magnetic field 的作用下，graphene 的情况如何呢？
bandgap 能打开？ 还是打开excitonic condensation gap?还是其他情况？？
2. four-terminal graphene device 在perpendicular magnetic field 的作用下，发
现测量的电阻（不是hall effect 磁阻）线性或者非线性的随着磁场增加而增加，也就
是： R vs B， 这个如何解释？
希望前辈指教！ |
|
b***a
发帖数: 377 | 40 看起来好像研究成果不是很强吧?
南策文
教授
清华大学材料科学与工程研究院 院长
电话：010-62773587
传真：010-62772507
E-mail：[email protected]
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/* ]]> */
教育背景
1982.07，于华东理工大学获学士学位
1985.03，于华东理工大学获硕士学位
199... 阅读全帖 |
|
b***a
发帖数: 377 | 41 看起来好像研究成果不是很强吧?
南策文
教授
清华大学材料科学与工程研究院 院长
电话：010-62773587
传真：010-62772507
E-mail：[email protected]
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教育背景
1982.07，于华东理工大学获学士学位
1985.03，于华东理工大学获硕士学位
199... 阅读全帖 |
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q*d
发帖数: 22178 | 42 印象里，见他发过一片Rev of Mod Phys
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23(
bilayered
and
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19
composites
2003).
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q*******u
发帖数: 68 | 43 I prepared bilayer structure, YBCO covered by YBCFeO, it is a kind of
superconductor and normal metal (NS) juctions. The thicknesses of them
are 80nm. In the previous publication, some one studied the effect of
proximity effect on Tc, a good model was developed for both s- and d-wave
superconductors. The thickness dependence of Tc also is studied. It was
shown that Tc is close to its bulk values when the thickness of YBCO
on STO is more than 80nm. in addition, the stress is smaller when the fil |
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